GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | multiple interactions | EXP | | 6480464 | CTD | diphenyleneiodonium inhibits the reaction [Palmitates results in increased expression of TNF mRNA]; diphenyleneiodonium inhibits the reaction [Palmitates results in increased expression of TNF protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; diphenyleneiodonium inhibits the reaction [TNF protein affects the localization of RELA protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Vehicle Emissions results in increased expression of TNF protein] | PMID:17471172 PMID:18474546 PMID:23774252 | Tnf | decreases response to substance | ISO | TNF (Homo sapiens) | 6480464 | CTD | diphenyleneiodonium results in decreased susceptibility to TNF protein | PMID:21211511 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] | PMID:12388057 PMID:19608869 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased secretion of IL1B protein] | PMID:14576080 PMID:16632126 PMID:19608869 PMID:21211511 PMID:23940760 | | ||||||||||||||||||||||
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