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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:3312
Term: calcium dichloride
Definition: A calcium salt that has formula CaCl2.
Chemical ID: MESH:D002122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDCalcium Chloride results in increased expression of TNF proteinPMID:36731150
Tnfmultiple interactionsEXP 6480464CTDcordycepin inhibits the reaction [Calcium Chloride results in increased expression of TNF protein]PMID:36731150
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDCalcium Chloride results in increased expression of TNF mRNA; Calcium Chloride results in increased expression of TNF proteinPMID:21530968 PMID:22728078
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDQuercetin inhibits the reaction [Calcium Chloride results in increased expression of TNF protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of TNF mRNA]PMID:21530968 PMID:22728078
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDCalcium Chloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]PMID:36416909
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