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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:27418
Term: 1,4-naphthoquinone
Definition: The parent structure of the family of 1,4-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 4 of the naphthalene ring. Derivatives have pharmacological properties.
Chemical ID: MESH:C035342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTD1,4-naphthoquinone results in increased expression of TNF mRNAPMID:23333790
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD1,4-naphthoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:21235518
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