GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | increases expression | EXP | | 6480464 | CTD | Apigenin results in increased expression of TNF protein | PMID:24144774 | Tnf | multiple interactions | EXP | | 6480464 | CTD | Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of TNF protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Apigenin promotes the reaction [hydroxygenkwanin results in increased expression of TNF protein]; hydroxygenkwanin promotes the reaction [Apigenin results in increased expression of TNF protein] | PMID:24144774 PMID:25557508 PMID:25935278 PMID:28389404 PMID:30152906 PMID:35373622 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | Apigenin inhibits the reaction [Alcohols results in increased expression of TNF protein]; Apigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA] | PMID:15985724 PMID:28803762 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Apigenin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Apigenin inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein]; Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] | PMID:15113938 PMID:15322261 PMID:16987811 PMID:24148603 PMID:30016632 PMID:36055550 PMID:36350155 | | ||||||||||||||||||||||
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