RGD Reference Report - Tumor necrosis factor alpha (TNF-alpha) polymorphisms in Chinese patients with Graves' disease. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Tumor necrosis factor alpha (TNF-alpha) polymorphisms in Chinese patients with Graves' disease.

Authors: Gu, LQ  Zhu, W  Pan, CM  Zhao, L  Zhang, MJ  Liu, JM  Song, HD  Ning, G  Zhao, YJ 
Citation: Gu LQ, etal., Clin Biochem. 2010 Feb;43(3):223-7. doi: 10.1016/j.clinbiochem.2009.08.012. Epub 2009 Sep 2.
RGD ID: 7394807
Pubmed: PMID:19732761   (View Abstract at PubMed)
DOI: DOI:10.1016/j.clinbiochem.2009.08.012   (Journal Full-text)

OBJECTIVES: Tumor necrosis factor alpha (TNF-alpha) may play a central role in the development of Graves' disease (GD). The aim of this study was to investigate the association of TNF-alpha polymorphisms with GD in Chinese population. DESIGN AND METHODS: Genomic DNA was extracted from peripheral blood lymphocyte of 436 GD patients and 316 control subjects. TNF-alpha polymorphisms at positions -308 (G-308A, rs1800629), -238 (G-238A, rs361525), and +419 (G+419A, rs3093661) were genotyped. RESULTS: The distribution of TNF-alpha -238 and +419 allelic frequencies between GD and control individuals was significantly different. Both the G alleles of TNF-alpha -238 (OR 2.385, 95%CI 1.359-4.184) and +419 (OR 2.293, 95%CI 1.303-4.035) SNPs conferred higher risk of GD as compared with A alleles. No significant difference of -308 allelic frequency was observed. Further haplotype analysis revealed that the haplotype GGG was associated with an increased risk of GD (OR 1.554, 95%CI 1.125-2.146), whereas the haplotype GAA was found to be protective (OR 0.419, 95%CI 0.239-0.736). CONCLUSIONS: This study demonstrated the association of TNF-alpha gene with GD in Chinese patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Graves' disease susceptibilityIAGP 7394807DNA:SNPs: :-238G>A(rs361525) and 419G>A(rs3093661)(human)RGD 
Graves' disease susceptibilityISOTNF (Homo sapiens)7394807; 7394807DNA:SNPs: :-238G>A(rs361525) and 419G>A(rs3093661)(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information