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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:51403
Term: 1,4-phenylenediamine
Definition: A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.
Chemical ID: MESH:C029728
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaffects response to substanceISOTNF (Homo sapiens)6480464CTDTNF gene polymorphism affects the susceptibility to 4-phenylenediaminePMID:18384449
Tnfincreases expressionISOTnf (Mus musculus)6480464CTD4-phenylenediamine results in increased expression of TNF proteinPMID:34826398
Tnfincreases secretionISOTnf (Mus musculus)6480464CTD4-phenylenediamine results in increased secretion of TNF proteinPMID:22245253
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTD4-phenylenediamine results in increased secretion of TNF proteinPMID:34826398
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDMRGPRX2 protein affects the reaction [4-phenylenediamine results in increased secretion of TNF protein]PMID:34826398
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