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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:8207
Term: (+)-pilocarpine
Definition: The (+)-enantiomer of pilocarpine.
Chemical ID: MESH:D010862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDPilocarpine results in decreased expression of TNF mRNA; Pilocarpine results in decreased expression of TNF proteinPMID:17872965 PMID:19055492
Tnfincreases expressionEXP 6480464CTDPilocarpine results in increased expression of TNF proteinPMID:18455351
Tnfmultiple interactionsEXP 6480464CTD[Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF protein; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]; Rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of TNF protein]PMID:17872965 PMID:18455351 PMID:31018114
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDPilocarpine results in increased expression of TNF mRNAPMID:15193289
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