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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDchromium hexavalent ion results in increased expression of TNF proteinPMID:35024197 PMID:36108929
Tnfmultiple interactionsEXP 6480464CTD[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of TNF protein; Ellagic Acid inhibits the reaction [chromium hexavalent ion results in increased expression of TNF protein]; Resveratrol inhibits the reaction [chromium hexavalent ion results in increased expression of TNF protein]; S-allylcysteine inhibits the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of TNF protein]PMID:28988497 PMID:35024197 PMID:36108929
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDchromium hexavalent ion results in increased secretion of TNF proteinPMID:25448439
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of TNF mRNA; [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of TNF protein]PMID:25820237 PMID:36880428
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDLuteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of TNF protein]PMID:25448439
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