GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | increases expression | EXP | | 6480464 | CTD | Cholesterol analog results in increased expression of TNF mRNA | PMID:19477266 | Tnf | multiple interactions | EXP | | 6480464 | CTD | [Cholesterol co-treated with Particulate Matter] results in increased expression of TNF mRNA; [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of TNF mRNA]; alpha-Linolenic Acid inhibits the reaction [Cholesterol promotes the reaction [Particulate Matter results in increased expression of TNF protein]]; Cholesterol promotes the reaction [Particulate Matter results in increased expression of TNF protein] | PMID:19477266 PMID:26606054 PMID:30672636 | Tnf | increases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Cholesterol results in increased expression of TNF mRNA; Cholesterol results in increased expression of TNF protein | PMID:19028402 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | [Dietary Fats co-treated with bisphenol A co-treated with Cholesterol] results in increased secretion of TNF protein; Cholesterol inhibits the reaction [Irbesartan results in increased expression of TNF mRNA]; Cholesterol inhibits the reaction [Irbesartan results in increased expression of TNF protein] | PMID:19028402 PMID:33239236 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | [Cholesterol co-treated with CLEC4E] results in increased expression of TNF protein; [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] inhibits the reaction [Polystyrenes inhibits the reaction [TNF protein affects the localization of RELA protein]]; [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] inhibits the reaction [Polystyrenes inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]] | PMID:23274767 PMID:26296894 | | ||||||||||||||||||||||
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