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GENE - TERM ANNOTATION REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: DOID:12365
Term: malaria
Definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Malaria "DO" "DO", http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=malaria "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TnfsusceptibilityISOTNF (Homo sapiens)1624967RGDDNA:polymorphism:promoter:-376G>A 
TnfsusceptibilityISOTNF (Homo sapiens)7240710OMIM  
Tnf ISOTNF (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanism 
Tnf ISOTNF (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Malaria, cerebral, susceptibility toPMID:10369255 PMID:10450718 PMID:11261930 PMID:11506397 PMID:11826025 PMID:11896460 PMID:12485196 PMID:12746914 PMID:12759288 PMID:14681301 PMID:14718719 PMID:16418737 PMID:16720636 PMID:16865291 PMID:16909270 PMID:18050183 PMID:18713756 PMID:19365401 PMID:22760475 PMID:22992668 PMID:8056188 PMID:9818939
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