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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:34316
Term: 3'-O-(4-Benzoyl)benzoyl ATP
Definition: A purine ribonucleoside triphosphate that has formula C24H24N5O15P3.
Chemical ID: MESH:C033901
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases secretionISOTnf (Mus musculus)6480464CTD3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of TNF proteinPMID:26522449
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDazetidine analog inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of TNF protein]; N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of TNF protein]PMID:26522449
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