RGD Reference Report - Genetic polymorphisms in TNF genes and tuberculosis in North Indians. - Rat Genome Database

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Genetic polymorphisms in TNF genes and tuberculosis in North Indians.

Authors: Sharma, S  Rathored, J  Ghosh, B  Sharma, SK 
Citation: Sharma S, etal., BMC Infect Dis. 2010 Jun 10;10:165.
RGD ID: 4143229
Pubmed: PMID:20537163   (View Abstract at PubMed)
PMCID: PMC2894837   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2334-10-165   (Journal Full-text)

BACKGROUND: Pulmonary tuberculosis, the most common clinical form of mycobacterial diseases, is a granulomatous disease of the lungs caused by Mycobaterium tuberculosis. A number of genes have been identified in studies of diverse origins to be important in tuberculosis. Of these, both tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) play important immunoregulatory roles. METHODS: To investigate the association of TNF polymorphisms with tuberculosis in the Asian Indians, we genotyped five potentially functional promoter polymorphisms in the TNFA gene and a LTA_NcoI polymorphism (+252 position) of the LTA gene in a clinically well-defined cohort of North-Indian patients with tuberculosis (N = 185) and their regional controls (N = 155). Serum TNF-alpha (sTNF-alpha) levels were measured and correlated with genotypes and haplotypes. RESULTS: The comparison of the allele frequencies for the various loci investigated revealed no significant differences between the tuberculosis patients and controls. Also, when the patients were sub-grouped into minimal, moderately advanced and far advanced disease on the basis of chest radiographs, TST and the presence/absence of cavitary lesions, none of the polymorphisms showed a significant association with any of the patient sub-groups. Although a significant difference was observed in the serum TNF-alpha levels in the patients and the controls, none of the investigated polymorphisms were found to affect the sTNF-alpha levels. Interestingly, it was observed that patients with minimal severity were associated with lower log sTNF-alpha levels when compared to the patients with moderately advanced and far advanced severity. However, none of these differences were found to be statistically significant. Furthermore, when haplotypes were analyzed, no significant difference was observed. CONCLUSIONS: Thus, our findings exclude the TNF genes as major risk factor for tuberculosis in the North Indians.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
tuberculosis  IEP 4143229protein:increased expression:serumRGD 
tuberculosis  ISOTNF (Homo sapiens)4143229; 4143229protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information