GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | increases expression | EXP | | 6480464 | CTD | Diclofenac results in increased expression of TNF mRNA; Diclofenac results in increased expression of TNF protein | PMID:15135310 PMID:28535741 PMID:29027214 | Tnf | increases response to substance | EXP | | 6480464 | CTD | TNF protein results in increased susceptibility to Diclofenac | PMID:23939143 | Tnf | multiple interactions | EXP | | 6480464 | CTD | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of TNF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Silymarin inhibits the reaction [Diclofenac results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Diclofenac results in increased expression of TNF protein]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] | PMID:19393675 PMID:23395999 PMID:25450234 PMID:25935278 PMID:28535741 PMID:31042592 | Tnf | increases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Diclofenac results in increased expression of TNF mRNA; Diclofenac results in increased expression of TNF protein | PMID:22285467 PMID:35537566 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Diclofenac results in increased expression of TNF mRNA | PMID:19022234 PMID:29027214 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | [Diclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein] | PMID:17328244 PMID:31926916 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; [TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Diclofenac inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diclofenac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Diclofenac promotes the reaction [Mustard Gas results in increased secretion of TNF protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein] | PMID:15489888 PMID:19362101 PMID:19691487 PMID:26609140 PMID:27313093 PMID:29777833 PMID:31048000 | | ||||||||||||||||||||||
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