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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDCorticosterone results in increased expression of TNF proteinPMID:32733244
Tnfmultiple interactionsEXP 6480464CTD[Corticosterone co-treated with Isoflurophate] results in increased expression of TNF mRNA; O-1602 compound inhibits the reaction [Corticosterone results in increased expression of TNF protein]PMID:28782715 PMID:32733244
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDCorticosterone results in increased expression of TNF mRNAPMID:28500787 PMID:29846716
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[Corticosterone co-treated with Isoflurophate] results in increased expression of TNF mRNA; [Corticosterone co-treated with O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate] results in increased expression of TNF mRNA; [Corticosterone co-treated with Physostigmine] results in increased expression of TNF mRNA; [Corticosterone co-treated with Pyridostigmine Bromide] results in increased expression of TNF mRNA; [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TNF mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TNF mRNA]; Corticosterone promotes the reaction [Isoflurophate results in increased expression of TNF mRNA]; Corticosterone promotes the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of TNF mRNA]PMID:28500787 PMID:29751049 PMID:29846716
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