RGD Reference Report - Anti-TNF-alpha antibody reduces pain-behavioral changes induced by epidural application of nucleus pulposus in a rat model depending on the timing of administration. - Rat Genome Database

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Anti-TNF-alpha antibody reduces pain-behavioral changes induced by epidural application of nucleus pulposus in a rat model depending on the timing of administration.

Authors: Sasaki, N  Kikuchi, S  Konno, S  Sekiguchi, M  Watanabe, K 
Citation: Sasaki N, etal., Spine (Phila Pa 1976). 2007 Feb 15;32(4):413-6.
RGD ID: 7394757
Pubmed: PMID:17304130   (View Abstract at PubMed)
DOI: DOI:10.1097/01.brs.0000255097.18246.bc   (Journal Full-text)

STUDY DESIGN: An experimental animal study. OBJECTIVE: To study if antitumor necrosis factor-alpha (TNF-alpha) antibody, which is administered at different times, reduces the pain behavior induced by application of nucleus pulposus (NP) to the nerve root. SUMMARY OF BACKGROUND DATA: Treatment with TNF-alpha inhibitor reduces the pain-related behavior induced by epidural application of NP in rats. METHODS: Left L5 partial laminectomy was performed and NP was applied to the L5 nerve root in 24 rats. The rats were divided into 4 groups. In 3 groups, anti-rat TNF-alpha antibody was intravenously administered immediately after, or 6 or 20 days after NP application. The fourth group was not treated with anti-rat TNF-alpha antibody (untreated rats). The withdrawal threshold of the plantar surface was determined 1 day before up through 28 days after NP application. RESULTS: The withdrawal threshold of rats that had been treated with anti-rat TNF-alpha antibody immediately after or 6 days after, but not 20 days after, NP application, was significantly higher than that of the untreated rats. CONCLUSIONS: Anti-TNF-alpha antibody reduced allodynia only when it was administered soon after the onset of allodynia. Late administration of anti-TNF-alpha antibody did not have an antiallodynic effect.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hyperalgesia  ISOTnf (Rattus norvegicus)7394757; 7394757 RGD 
Hyperalgesia  IMP 7394757 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information