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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:41500
Term: 4-phenylbutyric acid
Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Chemical ID: MESH:C075773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionISOTnf (Mus musculus)6480464CTD4-phenylbutyric acid results in decreased expression of TNF mRNAPMID:28698385
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of TNF protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of TNF mRNA]; 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of TNF mRNA]; 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; 4-phenylbutyric acid inhibits the reaction [SR 1078 results in increased expression of TNF protein]PMID:27578021 PMID:28245985 PMID:28698385 PMID:35413383
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