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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaffects expressionEXP 6480464CTDCadmium affects the expression of TNFPMID:26051590
Tnfdecreases expressionEXP 6480464CTDCadmium results in decreased expression of TNF mRNAPMID:24828341 PMID:36278208
Tnfincreases expressionEXP 6480464CTDCadmium results in increased expression of TNF mRNA; Cadmium results in increased expression of TNF proteinPMID:20455018 PMID:21627960 PMID:25808797 PMID:37342552 PMID:37403423 PMID:37949422
Tnfincreases secretionEXP 6480464CTDCadmium results in increased secretion of TNF proteinPMID:20105457
Tnfmultiple interactionsEXP 6480464CTD[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of TNF protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; bergenin inhibits the reaction [Cadmium results in increased expression of TNF protein]; Cadmium inhibits the reaction [TNF protein affects the localization of CYCS protein]; Cadmium inhibits the reaction [TNF protein results in increased activity of CASP9 protein]; Cadmium inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]; Cadmium inhibits the reaction [TNF protein results in increased cleavage of BID protein]; Cadmium inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of TNF protein]; galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Lithium inhibits the reaction [Cadmium results in increased expression of TNF protein]; Mirtazapine inhibits the reaction [Cadmium results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of TNF protein]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Triiodothyronine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]PMID:16263807 PMID:20455018 PMID:29170048 PMID:31390532 PMID:31639282 PMID:35384154 PMID:36718047 PMID:36868496 PMID:37342552 PMID:37403423 PMID:37949422
Tnfaffects expressionISOTnf (Mus musculus)6480464CTDCadmium affects the expression of TNF mRNAPMID:26363317
Tnfaffects expressionISOTNF (Homo sapiens)6480464CTDCadmium affects the expression of TNF mRNAPMID:21694771
Tnfdecreases expressionISOTnf (Mus musculus)6480464CTDCadmium results in decreased expression of TNF mRNAPMID:28666365 PMID:29111403
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDCadmium results in increased expression of TNF; Cadmium results in increased expression of TNF proteinPMID:25149082 PMID:37357614
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDCadmium results in increased expression of TNF mRNAPMID:27687512 PMID:33559965 PMID:37357614
Tnfincreases response to substanceISOTnf (Mus musculus)6480464CTDCadmium results in increased susceptibility to TNF; TNF results in increased susceptibility to CadmiumPMID:12189181
Tnfincreases response to substanceISOTNF (Homo sapiens)6480464CTDTNF results in increased susceptibility to CadmiumPMID:12189181
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDCadmium results in increased secretion of TNF proteinPMID:36094808
Tnfincreases uptakeISOTNF (Homo sapiens)6480464CTDTNF protein results in increased uptake of CadmiumPMID:22345571
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Cadmium results in increased expression of TNF protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein; [Cadmium co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; [ITPR3 mutant form results in increased susceptibility to Cadmium] which results in increased expression of TNF mRNA; [NFE2L2 protein affects the susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]] which results in increased expression of TNF mRNA; Cadmium inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TNF protein]; Cadmium inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Cadmium inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Cadmium promotes the reaction [ITPR3 mutant form results in increased expression of TNF mRNA]; TNF promotes the reaction [Cadmium results in increased expression of TRP53 protein]; TRP53 affects the reaction [Cadmium results in increased susceptibility to TNF]; TRP53 affects the reaction [TNF results in increased susceptibility to Cadmium]; TRP53 gene mutant form inhibits the reaction [TNF results in increased susceptibility to Cadmium]; TRP53 protein mutant form inhibits the reaction [TNF results in increased susceptibility to Cadmium]PMID:12189181 PMID:26363317 PMID:32917723 PMID:33359024 PMID:33398418 PMID:37047547 PMID:37357614 PMID:7676455
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of TNF mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased secretion of TNF protein; [Cadmium co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased expression of TNF mRNA; Cadmium results in increased expression of and results in increased secretion of TNF protein; GSK872 affects the reaction [[Cadmium co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased expression of TNF mRNA]; GSK872 affects the reaction [Cadmium results in increased expression of TNF mRNA]; MitoTEMPO inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA]; Selenium inhibits the reaction [Cadmium results in increased expression of and results in increased secretion of TNF protein]; SLC39A8 mutant form inhibits the reaction [TNF protein results in increased uptake of Cadmium]PMID:21481475 PMID:22345571 PMID:29028684 PMID:32917723 PMID:34510229 PMID:36602393 PMID:37357614
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