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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:49553
Term: copper(II) chloride
Definition: An inorganic chloride of copper in which the metal is in the +2 oxidation state.
Chemical ID: MESH:C029892
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases secretionEXP 6480464CTDcupric chloride results in increased secretion of TNF proteinPMID:24530511
Tnfmultiple interactionsEXP 6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [cupric chloride results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [cupric chloride results in increased secretion of TNF protein]; SC 514 inhibits the reaction [cupric chloride results in increased secretion of TNF protein]PMID:24530511
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDcupric chloride results in increased expression of TNF proteinPMID:23313662 PMID:24170445
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDcupric chloride results in increased secretion of TNF proteinPMID:22954531
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDcupric chloride inhibits the reaction [TNF protein results in increased secretion of IL6 protein]PMID:23285694
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