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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDepigallocatechin gallate results in decreased expression of TNF mRNA; epigallocatechin gallate results in decreased expression of TNF proteinPMID:27659729
Tnfmultiple interactionsEXP 6480464CTD[candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [Gentamicins results in increased expression of TNF protein]PMID:30368989
Tnfaffects expressionISOTnf (Mus musculus)6480464CTDepigallocatechin gallate affects the expression of TNFPMID:25955525
Tnfdecreases secretionISOTnf (Mus musculus)6480464CTDepigallocatechin gallate results in decreased secretion of TNF proteinPMID:12628509
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDepigallocatechin gallate affects the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [Formaldehyde results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [Okadaic Acid results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]PMID:10757128 PMID:16516891 PMID:20438794 PMID:27890776 PMID:28365685 PMID:30395894 PMID:36056792
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]PMID:19557821 PMID:26187476 PMID:27890776
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