RGD Reference Report - Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. - Rat Genome Database

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Genetic risk for coronary artery disease in individuals with or without type 2 diabetes.

Authors: Yamada, Y  Ichihara, S  Izawa, H  Tanaka, M  Yokota, M 
Citation: Yamada Y, etal., Mol Genet Metab. 2004 Apr;81(4):282-90.
RGD ID: 1626412
Pubmed: PMID:15059615   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ymgme.2004.01.014   (Journal Full-text)

Given that a substantial proportion of individuals with coronary artery disease (CAD) also have type 2 diabetes, it is important to identify genes that confer susceptibility to CAD independently in subjects with type 2 diabetes and in those without this condition. A large-scale association study was performed to identify genes that confer susceptibility to CAD in either the absence or presence of type 2 diabetes. The study population comprised 5207 unrelated Japanese individuals, including 3085 subjects with CAD and 2122 controls. Among all subjects, 1704 individuals had type 2 diabetes and 3503 individuals did not have this condition. The genotypes for 33 polymorphisms of 27 candidate genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, hypertension, hypercholesterolemia, and hyperuricemia revealed that the following polymorphisms were significantly (P < 0.005) associated with CAD: the 1019C -->T of the connexin 37 gene for men with type 2 diabetes; the 2445G -->A in the fatty acid-binding protein 2 gene for women with this condition; the -863C-->A in the tumor necrosis factor-alpha gene, the -219G-->T in the apolipoprotein E gene, the 1019C-->T in the connexin 37 gene for men without type 2 diabetes; and the -482C-->T in the apolipoprotein C-III gene for women without this condition. Genotyping of these polymorphisms may prove informative for assessment of the genetic risk for CAD in the absence or presence of type 2 diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
coronary artery disease  IAGP 1626412DNA:SNP:promoter:-482C>T more ...RGD 
coronary artery disease  IAGP 1626412associated with Diabetes Mellitus more ...RGD 
coronary artery disease  ISOAPOC3 (Homo sapiens)1626412; 1626412 RGD 
coronary artery disease  ISOAPOE (Homo sapiens)1626412; 1626412associated with Diabetes Mellitus more ...RGD 
coronary artery disease  IAGP 1626412DNA:SNP:CDS:2445G>A more ...RGD 
coronary artery disease  ISOFABP2 (Homo sapiens)1626412; 1626412associated with Diabetes Mellitus and Type 2 (MeSH:D003924)RGD 
coronary artery disease  IAGP 1626412DNA:SNP:CDS:1019C>T more ...RGD 
coronary artery disease  ISOGJA4 (Homo sapiens)1626412; 1626412 RGD 
coronary artery disease  IAGP 1626412DNA:SNP:promoter:-863C>A more ...RGD 
coronary artery disease  ISOTNF (Homo sapiens)1626412; 1626412 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoc3  (apolipoprotein C3)
Apoe  (apolipoprotein E)
Fabp2  (fatty acid binding protein 2)
Gja4  (gap junction protein, alpha 4)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Apoc3  (apolipoprotein C-III)
Apoe  (apolipoprotein E)
Fabp2  (fatty acid binding protein 2, intestinal)
Gja4  (gap junction protein, alpha 4)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
APOC3  (apolipoprotein C3)
APOE  (apolipoprotein E)
FABP2  (fatty acid binding protein 2)
GJA4  (gap junction protein alpha 4)
TNF  (tumor necrosis factor)


Additional Information