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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:82436
Term: decabromodiphenyl ether
Definition: A polybromodiphenyl ether that is diphenyl ether in which all of the hydrogens have been replaced by bromines.
Chemical ID: MESH:C010902
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDdecabromobiphenyl ether results in increased expression of TNF mRNAPMID:23640034 PMID:36566971
Tnfincreases secretionEXP 6480464CTDdecabromobiphenyl ether results in increased secretion of TNF proteinPMID:36566971
Tnfmultiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [decabromobiphenyl ether results in increased expression of TNF protein]PMID:36566971
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDdecabromobiphenyl ether results in increased expression of TNF proteinPMID:30836164
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDdecabromobiphenyl ether results in increased expression of TNF proteinPMID:33675858
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of TNF protein]; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of TNF protein]PMID:30836164
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDLuteolin inhibits the reaction [decabromobiphenyl ether results in increased expression of TNF protein]PMID:33675858
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