GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | decreases expression | EXP | | 6480464 | CTD | Celecoxib results in decreased expression of TNF protein | PMID:17908994 | Tnf | multiple interactions | EXP | | 6480464 | CTD | Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]]; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of TNF protein]; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of TNF protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] | PMID:17908994 PMID:19247274 PMID:20039930 PMID:21893697 PMID:24932515 PMID:31628940 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | Celecoxib inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of TNF protein]; Celecoxib inhibits the reaction [Dihematoporphyrin Ether results in increased expression of TNF protein]; Celecoxib inhibits the reaction [lead acetate results in increased secretion of TNF protein] | PMID:16230411 PMID:20844471 PMID:24530660 PMID:32416088 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | [Polyphenols co-treated with Antioxidants co-treated with Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Medroxyprogesterone Acetate co-treated with Celecoxib] results in decreased expression of TNF; Celecoxib inhibits the reaction [Mustard Gas results in increased secretion of TNF protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Celecoxib inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Celecoxib inhibits the reaction [TNF protein results in increased activity of RELA protein]; Celecoxib inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Celecoxib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Celecoxib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] | PMID:15489888 PMID:16702388 PMID:31048000 | | ||||||||||||||||||||||
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