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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:75292
Term: phenanthridone
Definition: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.
Chemical ID: MESH:C040601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDphenanthridone results in decreased expression of TNF mRNAPMID:12411406
Tnfmultiple interactionsEXP 6480464CTDphenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]PMID:12411406
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDphenanthridone analog inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]PMID:12006805
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