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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:imipramine
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Accession:CHEBI:47499 term browser browse the term
Definition:A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Synonyms:exact_synonym: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
 related_synonym: 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine;   3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE;   5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine;   Antideprin;   Formula=C19H24N2;   Imipramin;   InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3;   InChIKey=BCGWQEUPMDMJNV-UHFFFAOYSA-N;   Irmin;   Melipramine;   N-(gamma-dimethylaminopropyl)iminodibenzyl;   SMILES=CN(C)CCCN1c2ccccc2CCc2ccccc12;   imipraminum;   imizine
 alt_id: CHEBI:47498;   CHEBI:5881
 xref: Beilstein:256892;   CAS:50-49-7;   DrugBank:DB00458;   Drug_Central:1427;   Gmelin:1572523;   HMDB:HMDB0001848;   KEGG:C07049;   KEGG:D08070;   LINCS:LSM-2852
 xref_mesh: MESH:D007099
 xref: PDBeChem:IXX;   PMID:20825390;   Patent:US2554736;   Reaxys:256892;   Wikipedia:Imipramine


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imipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAT aminoadipate aminotransferase affects expression ISO Imipramine affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr 4:170,060,222...170,094,292
Ensembl chr 4:170,060,222...170,091,699 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 affects expression ISO Imipramine affects the expression of ABCB1 mRNA CTD PMID:18355885 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ACE2 angiotensin converting enzyme 2 decreases expression EXP Imipramine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G ACHE acetylcholinesterase (Yt blood group) multiple interactions
increases activity
decreases activity		 EXP
ISO		 Imipramine inhibits the reaction [asoxime chloride inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]]; Imipramine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Imipramine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Imipramine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
Imipramine results in increased activity of ACHE protein
Imipramine results in decreased activity of ACHE protein		 CTD PMID:25522658 PMID:29614332 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ADRB1 adrenoceptor beta 1 multiple interactions
decreases activity		 ISO [Imipramine co-treated with Idazoxan] results in decreased activity of ADRB1 protein; [Imipramine co-treated with Yohimbine] results in decreased activity of ADRB1 protein
Imipramine results in decreased activity of ADRB1 protein		 CTD PMID:2868116 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904 		JBrowse link
G ADRB2 adrenoceptor beta 2 decreases expression EXP Imipramine results in decreased expression of ADRB2 protein CTD PMID:10618463 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623 		JBrowse link
G ALB albumin affects binding EXP Imipramine binds to ALB protein CTD PMID:20956006 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 affects expression ISO Imipramine affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G AP2M1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO Imipramine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr 3:184,174,855...184,184,091
Ensembl chr 3:184,174,689...184,184,214 		JBrowse link
G APOA4 apolipoprotein A4 affects expression ISO Imipramine affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304 		JBrowse link
G ARG1 arginase 1 multiple interactions ISO Imipramine affects the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of ARG1 protein]] CTD PMID:30620895 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332 		JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 increases expression EXP Imipramine results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998 		JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Imipramine results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542 		JBrowse link
G BDNF brain derived neurotrophic factor increases expression
multiple interactions
affects expression		 ISO Imipramine results in increased expression of BDNF mRNA
Rolipram promotes the reaction [Imipramine results in increased expression of BDNF mRNA]
Imipramine affects the expression of BDNF protein		 CTD PMID:8601816 PMID:15157811 PMID:17617388 PMID:17950272 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase affects expression ISO Imipramine affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 EXP Imipramine results in increased cleavage of and results in increased activity of CASP3 protein; Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP3 protein] CTD PMID:10487422 PMID:22700542 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP7 caspase 7 increases activity
multiple interactions		 EXP Imipramine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP7 protein]		 CTD PMID:22700542 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 multiple interactions ISO Imipramine inhibits the reaction [lead acetate results in increased activity of CASP8 protein] CTD PMID:22033380 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CAT catalase affects activity
multiple interactions		 ISO Imipramine affects the activity of CAT protein
Imipramine inhibits the reaction [Streptozocin results in increased activity of CAT protein]		 CTD PMID:19798453 PMID:34352274 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C affects expression ISO Imipramine affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 1:50,968,706...50,974,634
Ensembl chr 1:50,960,745...50,974,634 		JBrowse link
G CES2 carboxylesterase 2 affects expression ISO Imipramine affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096 		JBrowse link
G CMTM6 CKLF like MARVEL transmembrane domain containing 6 affects expression ISO Imipramine affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 3:32,481,312...32,502,852
Ensembl chr 3:32,481,312...32,502,852 		JBrowse link
G CNR1 cannabinoid receptor 1 decreases expression ISO Imipramine results in decreased expression of CNR1 protein CTD PMID:28866072 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G CNR2 cannabinoid receptor 2 increases expression ISO Imipramine results in increased expression of CNR2 protein CTD PMID:28866072 NCBI chr 1:23,870,515...23,913,362
Ensembl chr 1:23,870,515...23,913,362 		JBrowse link
G CPPED1 calcineurin like phosphoesterase domain containing 1 affects expression ISO Imipramine affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr16:12,659,799...12,803,887
Ensembl chr16:12,659,799...12,803,887 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 increases expression
increases phosphorylation
multiple interactions		 ISO Imipramine results in increased expression of CREB1 mRNA
Imipramine results in increased phosphorylation of CREB1 protein
Rolipram promotes the reaction [Imipramine results in increased expression of CREB1 mRNA]		 CTD PMID:8601816 PMID:22396798 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CREM cAMP responsive element modulator affects expression ISO Imipramine affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr10:35,126,846...35,212,958
Ensembl chr10:35,126,791...35,212,958 		JBrowse link
G CRH corticotropin releasing hormone affects activity ISO Imipramine affects the activity of CRH protein CTD PMID:2553044 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects metabolic processing
increases metabolic processing
multiple interactions		 EXP CYP1A2 protein affects the metabolism of Imipramine
CYP1A2 protein results in increased metabolism of Imipramine
CYP1A2 protein results in decreased methylation of and results in increased activity of Imipramine; Imipramine inhibits the reaction [resveratrol results in decreased activity of CYP1A2 protein]; Organophosphorus Compounds inhibits the reaction [CYP1A2 protein results in decreased methylation of and results in increased activity of Imipramine]		 CTD PMID:11714871 PMID:15286053 PMID:15922009 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A member 13 affects expression ISO Imipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 affects metabolic processing
multiple interactions		 EXP CYP2C19 protein affects the metabolism of Imipramine
CYP2C19 protein results in decreased methylation of and results in increased activity of Imipramine; Organophosphorus Compounds inhibits the reaction [CYP2C19 protein results in decreased methylation of and results in increased activity of Imipramine]		 CTD PMID:15286053 PMID:15922009 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 affects metabolic processing EXP CYP2D6 protein affects the metabolism of Imipramine CTD PMID:15286053 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine; Organophosphorus Compounds inhibits the reaction [CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine] CTD PMID:15922009 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP4F12 cytochrome P450 family 4 subfamily F member 12 affects expression ISO Imipramine affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr19:15,673,087...15,697,174
Ensembl chr19:15,673,018...15,697,174 		JBrowse link
G DCAF8 DDB1 and CUL4 associated factor 8 affects expression ISO Imipramine affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr 1:160,215,720...160,262,549
Ensembl chr 1:160,215,715...160,262,549 		JBrowse link
G DEPP1 DEPP autophagy regulator 1 increases expression EXP Imipramine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr10:44,976,128...44,978,809
Ensembl chr10:44,970,981...44,978,809 		JBrowse link
G DNAJC5 DnaJ heat shock protein family (Hsp40) member C5 increases expression EXP Imipramine results in increased expression of DNAJC5 mRNA; Imipramine results in increased expression of DNAJC5 protein CTD PMID:11257428 NCBI chr20:63,895,126...63,936,011
Ensembl chr20:63,895,126...63,936,031 		JBrowse link
G EIF4B eukaryotic translation initiation factor 4B affects expression ISO Imipramine affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr12:53,006,456...53,042,215
Ensembl chr12:53,006,282...53,042,215 		JBrowse link
G EPHX1 epoxide hydrolase 1 affects expression ISO Imipramine affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 affects expression ISO Imipramine affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:112,013,426...112,023,449
Ensembl chr12:112,013,348...112,023,449 		JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Imipramine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062 		JBrowse link
G FNDC4 fibronectin type III domain containing 4 increases expression EXP Imipramine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 2:27,491,883...27,495,200
Ensembl chr 2:27,491,883...27,495,200 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Imipramine results in decreased expression of FOS mRNA CTD PMID:7612155 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GAP43 growth associated protein 43 decreases expression ISO Imipramine results in decreased expression of GAP43 mRNA CTD PMID:17950272 NCBI chr 3:115,623,510...115,721,483
Ensembl chr 3:115,623,510...115,721,490 		JBrowse link
G GCKR glucokinase regulator affects expression ISO Imipramine affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 2:27,496,839...27,523,684
Ensembl chr 2:27,496,839...27,523,684 		JBrowse link
G GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression EXP Imipramine results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr16:30,104,810...30,113,537
Ensembl chr16:30,104,810...30,113,537 		JBrowse link
G GLS2 glutaminase 2 affects expression ISO Imipramine affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr12:56,470,952...56,488,161
Ensembl chr12:56,470,944...56,488,414 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 affects expression ISO Imipramine affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342 		JBrowse link
G GRB14 growth factor receptor bound protein 14 affects expression ISO Imipramine affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 2:164,492,417...164,621,482
Ensembl chr 2:164,492,417...164,621,482 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP Imipramine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity EXP Imipramine results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HAL histidine ammonia-lyase affects expression ISO Imipramine affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr12:95,972,662...95,996,344
Ensembl chr12:95,972,662...95,996,365 		JBrowse link
G HDAC5 histone deacetylase 5 increases expression ISO Imipramine results in increased expression of HDAC5 mRNA CTD PMID:17988634 NCBI chr17:44,076,753...44,123,641
Ensembl chr17:44,076,746...44,123,702 		JBrowse link
G HMBS hydroxymethylbilane synthase decreases activity ISO Imipramine results in decreased activity of HMBS protein CTD PMID:10416826 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G HMGB2 high mobility group box 2 affects expression ISO Imipramine affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr 4:173,331,376...173,334,358
Ensembl chr 4:173,331,376...173,334,432 		JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Imipramine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 5:43,287,470...43,313,412
Ensembl chr 5:43,287,470...43,313,512 		JBrowse link
G HPN hepsin increases expression EXP Imipramine results in increased expression of HPN mRNA CTD PMID:15342952 PMID:17567588 NCBI chr19:35,040,506...35,066,573
Ensembl chr19:35,040,506...35,066,573 		JBrowse link
G HSF1 heat shock transcription factor 1 decreases activity EXP Imipramine results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 increases expression ISO Imipramine results in increased expression of HSPA8 mRNA alternative form; Imipramine results in increased expression of HSPA8 protein alternative form CTD PMID:10425221 NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A affects expression ISO Imipramine affects the expression of HTR1A mRNA CTD PMID:17617388 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A decreases expression ISO Imipramine results in decreased expression of HTR2A CTD PMID:2553044 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO Imipramine affects the reaction [caryophyllene promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL10 protein]] CTD PMID:30620895 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Imipramine affects the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]]; Imipramine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein] CTD PMID:30620895 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL33 interleukin 33 affects expression ISO Imipramine affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983 		JBrowse link
G INHBE inhibin subunit beta E increases expression EXP Imipramine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17567588 NCBI chr12:57,455,307...57,458,025
Ensembl chr12:57,452,323...57,459,280 		JBrowse link
G KCNH1 potassium voltage-gated channel subfamily H member 1 multiple interactions EXP Imipramine binds to and results in decreased activity of KCNH1 protein CTD PMID:18497958 NCBI chr 1:210,678,314...211,134,148
Ensembl chr 1:210,676,823...211,134,165 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
decreases localization		 EXP
ISO		 Imipramine binds to and results in decreased activity of KCNH2 protein; Imipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Imipramine results in decreased activity of KCNH2 protein
Imipramine results in decreased localization of KCNH2 protein		 CTD PMID:15272206 PMID:19583963 PMID:21158687 PMID:21525004 PMID:24052561 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G KCNN2 potassium calcium-activated channel subfamily N member 2 decreases activity ISO Imipramine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr 5:114,055,978...114,496,496
Ensembl chr 5:114,055,926...114,496,500 		JBrowse link
G LOX lysyl oxidase affects expression ISO Imipramine affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,413 		JBrowse link
G LSS lanosterol synthase increases expression EXP Imipramine results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824 		JBrowse link
G MACROH2A1 macroH2A.1 histone affects expression ISO Imipramine affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr 5:135,334,381...135,399,887
Ensembl chr 5:135,334,381...135,399,914 		JBrowse link
G MANBA mannosidase beta affects expression ISO Imipramine affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 4:102,630,770...102,760,968
Ensembl chr 4:102,630,770...102,760,994 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Imipramine binds to and results in increased activity of MAPK1 protein]; Imipramine binds to and results in increased activity of MAPK1 protein CTD PMID:20484120 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Imipramine binds to and results in increased activity of MAPK3 protein]; Imipramine binds to and results in increased activity of MAPK3 protein CTD PMID:20484120 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MLX MAX dimerization protein MLX affects expression ISO Imipramine affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr17:42,567,100...42,573,203
Ensembl chr17:42,567,072...42,573,239 		JBrowse link
G MRPS18B mitochondrial ribosomal protein S18B affects expression ISO Imipramine affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr 6:30,617,840...30,626,392
Ensembl chr 6:30,617,840...30,626,395 		JBrowse link
G MSMO1 methylsterol monooxygenase 1 affects expression ISO Imipramine affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 increases expression EXP Imipramine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G NREP neuronal regeneration related protein affects expression ISO Imipramine affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr 5:111,728,802...111,976,932
Ensembl chr 5:111,662,621...111,997,464 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 multiple interactions
increases phosphorylation		 ISO Imipramine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]; Imipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form]; Imipramine results in increased phosphorylation of and results in increased activity of NTRK2 protein
Imipramine results in increased phosphorylation of NTRK2 protein		 CTD PMID:21666748 PMID:22396798 PMID:31631060 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator increases expression EXP Imipramine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,008 		JBrowse link
G OAF out at first homolog affects expression ISO Imipramine affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr11:120,211,032...120,230,334
Ensembl chr11:120,211,032...120,230,334 		JBrowse link
G ORM2 orosomucoid 2 multiple interactions
affects binding		 EXP Chlorpromazine inhibits the reaction [Imipramine binds to ORM2 protein alternative form]; Dipyridamole inhibits the reaction [Imipramine binds to ORM2 protein alternative form]; Disopyramide inhibits the reaction [Imipramine binds to ORM2 protein alternative form]; Lidocaine inhibits the reaction [Imipramine binds to ORM2 protein alternative form]; Methadone inhibits the reaction [Imipramine binds to ORM2 protein alternative form]; Progesterone inhibits the reaction [Imipramine binds to ORM2 protein alternative form] CTD PMID:8946472 NCBI chr 9:114,329,869...114,333,251
Ensembl chr 9:114,329,869...114,333,251 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Imipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PC pyruvate carboxylase affects expression ISO Imipramine affects the expression of PC mRNA CTD PMID:18355885 NCBI chr11:66,848,420...66,958,383
Ensembl chr11:66,848,417...66,958,386 		JBrowse link
G PECR peroxisomal trans-2-enoyl-CoA reductase affects expression ISO Imipramine affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 2:216,029,088...216,081,809
Ensembl chr 2:215,996,329...216,082,955 		JBrowse link
G PLCG1 phospholipase C gamma 1 multiple interactions ISO Imipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form] CTD PMID:22396798 NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801 		JBrowse link
G POMC proopiomelanocortin multiple interactions EXP Imipramine inhibits the reaction [Buspirone results in increased expression of POMC protein] CTD PMID:19762159 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G POR cytochrome p450 oxidoreductase affects expression ISO Imipramine affects the expression of POR mRNA CTD PMID:18355885 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha multiple interactions ISO Imipramine inhibits the reaction [Ethanol results in increased activity of PPP2CA protein] CTD PMID:20224005 NCBI chr 5:134,194,332...134,226,073
Ensembl chr 5:134,194,035...134,226,073 		JBrowse link
G RBL2 RB transcriptional corepressor like 2 affects expression ISO Imipramine affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648 		JBrowse link
G SCD stearoyl-CoA desaturase increases expression EXP Imipramine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826 		JBrowse link
G SERPINA3 serpin family A member 3 increases expression EXP Imipramine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr14:94,612,391...94,624,053
Ensembl chr14:94,612,384...94,624,055 		JBrowse link
G SERPINI1 serpin family I member 1 increases expression ISO Imipramine results in increased expression of SERPINI1 mRNA CTD PMID:16637596 NCBI chr 3:167,735,721...167,825,569
Ensembl chr 3:167,735,243...167,825,569 		JBrowse link
G SH3GL3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression ISO Imipramine affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr15:83,447,341...83,633,820
Ensembl chr15:83,447,228...83,618,743 		JBrowse link
G SHANK2 SH3 and multiple ankyrin repeat domains 2 decreases expression EXP Imipramine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr11:70,467,854...71,253,228
Ensembl chr11:70,467,854...71,252,577 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin]; Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:24947867 PMID:25106415 NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Imipramine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Imipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 multiple interactions EXP Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] CTD PMID:10966924 PMID:21697722 NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577 		JBrowse link
G SLC2A3 solute carrier family 2 member 3 decreases expression EXP Imipramine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...8,019,007 		JBrowse link
G SLC47A1 solute carrier family 47 member 1 decreases activity
multiple interactions		 EXP Imipramine results in decreased activity of SLC47A1 protein
Imipramine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]		 CTD PMID:16928787 PMID:21599003 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 decreases activity ISO Imipramine results in decreased activity of SLC6A4 protein CTD PMID:18561912 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G SLC6A6 solute carrier family 6 member 6 affects expression ISO Imipramine affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 3:14,402,576...14,489,349
Ensembl chr 3:14,402,576...14,489,349 		JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 affects expression ISO Imipramine affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Imipramine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP Imipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306 		JBrowse link
G ST13 ST13 Hsp70 interacting protein affects expression ISO Imipramine affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr22:40,824,535...40,856,639
Ensembl chr22:40,824,535...40,856,639 		JBrowse link
G STBD1 starch binding domain 1 affects expression ISO Imipramine affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr 4:76,306,733...76,311,130
Ensembl chr 4:76,306,733...76,311,130 		JBrowse link
G STMN1 stathmin 1 affects expression ISO Imipramine affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991 		JBrowse link
G TAC1 tachykinin precursor 1 decreases expression ISO Imipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472 		JBrowse link
G TAGLN transgelin decreases expression EXP Imipramine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17567588 NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464 		JBrowse link
G TEX261 testis expressed 261 affects expression ISO Imipramine affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 2:70,985,942...70,994,873
Ensembl chr 2:70,968,325...70,994,873 		JBrowse link
G TIMM10B translocase of inner mitochondrial membrane 10B affects expression ISO Imipramine affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr11:6,481,501...6,484,681
Ensembl chr11:6,481,501...6,484,681 		JBrowse link
G TMPRSS2 transmembrane serine protease 2 increases expression EXP Imipramine results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Imipramine affects the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]; Imipramine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
Imipramine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Imipramine promotes the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]		 CTD PMID:15946935 PMID:30529211 PMID:30620895 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression ISO Imipramine affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr19:18,563,766...18,577,550
Ensembl chr19:18,571,730...18,577,550 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 affects expression ISO Imipramine affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 affects metabolic processing
multiple interactions
increases glucuronidation		 EXP UGT1A4 protein affects the metabolism of Imipramine
Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine]
UGT1A4 protein results in increased glucuronidation of Imipramine; UGT1A4 protein SNP results in increased glucuronidation of Imipramine		 CTD PMID:9264550 PMID:14570768 PMID:15286053 PMID:15708967 PMID:25448279 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,736...233,773,300 		JBrowse link
G UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus affects expression ISO Imipramine affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr 4:69,588,417...69,653,247
Ensembl chr 4:69,588,417...69,653,249 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 affects expression ISO Imipramine affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
G WIPI1 WD repeat domain, phosphoinositide interacting 1 increases expression EXP Imipramine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr17:68,421,281...68,457,496
Ensembl chr17:68,420,948...68,457,513 		JBrowse link
clomipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAT aminoadipate aminotransferase affects expression ISO Clomipramine affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr 4:170,060,222...170,094,292
Ensembl chr 4:170,060,222...170,091,699 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 affects expression ISO Clomipramine affects the expression of ABCB1 mRNA CTD PMID:18355885 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 affects expression ISO Clomipramine affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G AP1S1 adaptor related protein complex 1 subunit sigma 1 decreases expression EXP Clomipramine results in decreased expression of AP1S1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:101,154,476...101,161,276
Ensembl chr 7:101,154,456...101,161,596 		JBrowse link
G APOA4 apolipoprotein A4 affects expression ISO Clomipramine affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304 		JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Clomipramine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase affects expression ISO Clomipramine affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 EXP
ISO		 Clomipramine results in increased cleavage of and results in increased activity of CASP3 protein; Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP3 protein] CTD PMID:10487422 PMID:22700542 PMID:28482088 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP7 caspase 7 multiple interactions
increases activity		 EXP Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 increases activity ISO Clomipramine results in increased activity of CASP8 protein CTD PMID:28482088 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity ISO Clomipramine results in increased activity of CASP9 protein CTD PMID:28482088 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase decreases expression EXP Clomipramine results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C affects expression ISO Clomipramine affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 1:50,968,706...50,974,634
Ensembl chr 1:50,960,745...50,974,634 		JBrowse link
G CES2 carboxylesterase 2 affects expression ISO Clomipramine affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096 		JBrowse link
G CMTM6 CKLF like MARVEL transmembrane domain containing 6 affects expression ISO Clomipramine affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 3:32,481,312...32,502,852
Ensembl chr 3:32,481,312...32,502,852 		JBrowse link
G CPPED1 calcineurin like phosphoesterase domain containing 1 affects expression ISO Clomipramine affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr16:12,659,799...12,803,887
Ensembl chr16:12,659,799...12,803,887 		JBrowse link
G CREM cAMP responsive element modulator affects expression ISO Clomipramine affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr10:35,126,846...35,212,958
Ensembl chr10:35,126,791...35,212,958 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP Clomipramine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A member 13 affects expression ISO Clomipramine affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195 		JBrowse link
G CYP4F12 cytochrome P450 family 4 subfamily F member 12 affects expression ISO Clomipramine affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr19:15,673,087...15,697,174
Ensembl chr19:15,673,018...15,697,174 		JBrowse link
G DCAF8 DDB1 and CUL4 associated factor 8 affects expression ISO Clomipramine affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr 1:160,215,720...160,262,549
Ensembl chr 1:160,215,715...160,262,549 		JBrowse link
G DEPP1 DEPP autophagy regulator 1 increases expression EXP Clomipramine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:44,976,128...44,978,809
Ensembl chr10:44,970,981...44,978,809 		JBrowse link
G DRD2 dopamine receptor D2 increases expression ISO Clomipramine results in increased expression of DRD2 protein CTD PMID:20619828 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G EIF4B eukaryotic translation initiation factor 4B affects expression ISO Clomipramine affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr12:53,006,456...53,042,215
Ensembl chr12:53,006,282...53,042,215 		JBrowse link
G EPHX1 epoxide hydrolase 1 affects expression ISO Clomipramine affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 affects expression ISO Clomipramine affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:112,013,426...112,023,449
Ensembl chr12:112,013,348...112,023,449 		JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Clomipramine results in increased expression of FABP1 mRNA CTD PMID:15342952 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062 		JBrowse link
G FH fumarate hydratase multiple interactions ISO Clomipramine results in increased activity of and results in increased secretion of FH protein CTD PMID:37217012 NCBI chr 1:241,497,603...241,519,755
Ensembl chr 1:241,497,511...241,519,799 		JBrowse link
G FNDC4 fibronectin type III domain containing 4 increases expression
decreases expression		 EXP Clomipramine results in increased expression of FNDC4 mRNA
Clomipramine results in decreased expression of FNDC4 mRNA		 CTD PMID:17175557 NCBI chr 2:27,491,883...27,495,200
Ensembl chr 2:27,491,883...27,495,200 		JBrowse link
G GCKR glucokinase regulator affects expression ISO Clomipramine affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 2:27,496,839...27,523,684
Ensembl chr 2:27,496,839...27,523,684 		JBrowse link
G GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression EXP Clomipramine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr16:30,104,810...30,113,537
Ensembl chr16:30,104,810...30,113,537 		JBrowse link
G GLS2 glutaminase 2 affects expression ISO Clomipramine affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr12:56,470,952...56,488,161
Ensembl chr12:56,470,944...56,488,414 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 affects expression ISO Clomipramine affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342 		JBrowse link
G GPT glutamic--pyruvic transaminase increases export
multiple interactions		 ISO Clomipramine results in increased export of GPT protein
Clomipramine results in increased activity of and results in increased secretion of GPT protein		 CTD PMID:37217012 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GRB14 growth factor receptor bound protein 14 affects expression ISO Clomipramine affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 2:164,492,417...164,621,482
Ensembl chr 2:164,492,417...164,621,482 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity EXP Clomipramine results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HAL histidine ammonia-lyase affects expression ISO Clomipramine affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr12:95,972,662...95,996,344
Ensembl chr12:95,972,662...95,996,365 		JBrowse link
G HMGB2 high mobility group box 2 affects expression ISO Clomipramine affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr 4:173,331,376...173,334,358
Ensembl chr 4:173,331,376...173,334,432 		JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Clomipramine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 5:43,287,470...43,313,412
Ensembl chr 5:43,287,470...43,313,512 		JBrowse link
G HPN hepsin increases expression EXP Clomipramine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr19:35,040,506...35,066,573
Ensembl chr19:35,040,506...35,066,573 		JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C affects binding
increases expression		 EXP
ISO		 Clomipramine binds to HTR2C protein
Clomipramine results in increased expression of HTR2C protein		 CTD PMID:18083778 PMID:20619828 NCBI chr  X:114,584,086...114,910,061
Ensembl chr  X:114,584,078...114,910,061 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL33 interleukin 33 affects expression ISO Clomipramine affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INHBE inhibin subunit beta E increases expression EXP Clomipramine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr12:57,455,307...57,458,025
Ensembl chr12:57,452,323...57,459,280 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Clomipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G LOX lysyl oxidase affects expression ISO Clomipramine affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,413 		JBrowse link
G LSS lanosterol synthase increases expression EXP Clomipramine results in increased expression of LSS mRNA CTD PMID:15342952 NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824 		JBrowse link
G MACROH2A1 macroH2A.1 histone affects expression ISO Clomipramine affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr 5:135,334,381...135,399,887
Ensembl chr 5:135,334,381...135,399,914 		JBrowse link
G MANBA mannosidase beta affects expression ISO Clomipramine affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 4:102,630,770...102,760,968
Ensembl chr 4:102,630,770...102,760,994 		JBrowse link
G MLX MAX dimerization protein MLX affects expression ISO Clomipramine affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr17:42,567,100...42,573,203
Ensembl chr17:42,567,072...42,573,239 		JBrowse link
G MRPS18B mitochondrial ribosomal protein S18B affects expression ISO Clomipramine affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr 6:30,617,840...30,626,392
Ensembl chr 6:30,617,840...30,626,395 		JBrowse link
G MSMO1 methylsterol monooxygenase 1 affects expression ISO Clomipramine affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 increases expression EXP Clomipramine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G NREP neuronal regeneration related protein affects expression ISO Clomipramine affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr 5:111,728,802...111,976,932
Ensembl chr 5:111,662,621...111,997,464 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 increases phosphorylation ISO Clomipramine results in increased phosphorylation of NTRK2 protein CTD PMID:22396798 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator increases expression EXP Clomipramine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,008 		JBrowse link
G OAF out at first homolog affects expression ISO Clomipramine affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr11:120,211,032...120,230,334
Ensembl chr11:120,211,032...120,230,334 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Clomipramine results in increased cleavage of PARP1 protein CTD PMID:10487422 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PC pyruvate carboxylase affects expression ISO Clomipramine affects the expression of PC mRNA CTD PMID:18355885 NCBI chr11:66,848,420...66,958,383
Ensembl chr11:66,848,417...66,958,386 		JBrowse link
G PECR peroxisomal trans-2-enoyl-CoA reductase affects expression ISO Clomipramine affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 2:216,029,088...216,081,809
Ensembl chr 2:215,996,329...216,082,955 		JBrowse link
G PHYH phytanoyl-CoA 2-hydroxylase increases expression EXP Clomipramine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr10:13,277,799...13,300,064
Ensembl chr10:13,277,796...13,302,412 		JBrowse link
G POR cytochrome p450 oxidoreductase affects expression ISO Clomipramine affects the expression of POR mRNA CTD PMID:18355885 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G PRL prolactin affects secretion
increases expression
multiple interactions
increases secretion		 EXP Clomipramine affects the secretion of PRL protein
Clomipramine results in increased expression of PRL protein
SLC6A4 polymorphism inhibits the reaction [Clomipramine affects the secretion of PRL protein]
Clomipramine results in increased secretion of PRL protein		 CTD PMID:3602989 PMID:7930386 PMID:17000009 PMID:19698552 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa increases expression EXP Clomipramine results in increased expression of PROC protein CTD PMID:17891354 NCBI chr 2:127,418,427...127,429,242
Ensembl chr 2:127,418,427...127,429,242 		JBrowse link
G RBL2 RB transcriptional corepressor like 2 affects expression ISO Clomipramine affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648 		JBrowse link
G SCD stearoyl-CoA desaturase increases expression EXP Clomipramine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826 		JBrowse link
G SERPINA3 serpin family A member 3 increases expression EXP Clomipramine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr14:94,612,391...94,624,053
Ensembl chr14:94,612,384...94,624,055 		JBrowse link
G SH3GL3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression ISO Clomipramine affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr15:83,447,341...83,633,820
Ensembl chr15:83,447,228...83,618,743 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Clomipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC2A3 solute carrier family 2 member 3 decreases expression EXP Clomipramine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...8,019,007 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 multiple interactions EXP Clomipramine binds to and results in decreased activity of SLC6A4 protein; SLC6A4 polymorphism inhibits the reaction [Clomipramine affects the secretion of PRL protein] CTD PMID:16272152 PMID:17000009 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G SLC6A6 solute carrier family 6 member 6 affects expression ISO Clomipramine affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 3:14,402,576...14,489,349
Ensembl chr 3:14,402,576...14,489,349 		JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 affects expression ISO Clomipramine affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Clomipramine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP Clomipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306 		JBrowse link
G ST13 ST13 Hsp70 interacting protein affects expression ISO Clomipramine affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr22:40,824,535...40,856,639
Ensembl chr22:40,824,535...40,856,639 		JBrowse link
G STBD1 starch binding domain 1 affects expression ISO Clomipramine affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr 4:76,306,733...76,311,130
Ensembl chr 4:76,306,733...76,311,130 		JBrowse link
G STMN1 stathmin 1 affects expression ISO Clomipramine affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991 		JBrowse link
G TAC1 tachykinin precursor 1 decreases expression ISO Clomipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472 		JBrowse link
G TAGLN transgelin decreases expression EXP Clomipramine results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464 		JBrowse link
G TEX261 testis expressed 261 affects expression ISO Clomipramine affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 2:70,985,942...70,994,873
Ensembl chr 2:70,968,325...70,994,873 		JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions EXP Clomipramine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G TIMM10B translocase of inner mitochondrial membrane 10B affects expression ISO Clomipramine affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr11:6,481,501...6,484,681
Ensembl chr11:6,481,501...6,484,681 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression ISO Clomipramine affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr19:18,563,766...18,577,550
Ensembl chr19:18,571,730...18,577,550 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 affects expression ISO Clomipramine affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus affects expression ISO Clomipramine affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr 4:69,588,417...69,653,247
Ensembl chr 4:69,588,417...69,653,249 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 affects expression ISO Clomipramine affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
G WIPI1 WD repeat domain, phosphoinositide interacting 1 increases expression EXP Clomipramine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr17:68,421,281...68,457,496
Ensembl chr17:68,420,948...68,457,513 		JBrowse link
trimipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Trimipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        pharmacological role 22059
          neurotransmitter agent 18856
            adrenergic agent 9408
              adrenergic uptake inhibitor 4764
                imipramine 133
                  clomipramine 89
                  imipramine hydrochloride 0
                  trimipramine + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic heterocyclic compound 22320
                                  organic heteropolycyclic compound 21317
                                    organic heterotricyclic compound 15971
                                      mancude organic heterotricyclic parent 383
                                        5H-dibenzo[b,f]azepine 133
                                          imipramine 133
                                            clomipramine 89
                                            imipramine hydrochloride 0
                                            trimipramine + 1
paths to the root