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Gene: SLC6A4 (solute carrier family 6 member 4) Homo sapiens
Symbol: SLC6A4
Name: solute carrier family 6 member 4
Description: Exhibits serotonin:sodium symporter activity. Involved in regulation of thalamus size; response to toxic substance; and serotonin uptake. Localizes to endomembrane system; membrane raft; and plasma membrane. Implicated in several diseases, including alcohol use disorder; anxiety disorder (multiple); autistic disorder; heart disease (multiple); and obstructive sleep apnea.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-HTT; 5-HTTLPR; 5-hydroxytryptamine (serotonin) transporter; 5-hydroxytryptamine transporter; 5HT transporter; 5HTT; hSERT; HTT; Na+/Cl- dependent serotonin transporter; obsessive-compulsive disorder 1; OCD1; serotonin transporter 1; SERT; SERT1; sodium-dependent serotonin transporter; solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; solute carrier family 6, member 4
Mus musculus (house mouse) : Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc6a4 (solute carrier family 6 member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc6a4 (solute carrier family 6 member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC6A4 (solute carrier family 6 member 4)
Canis lupus familiaris (dog) : SLC6A4 (solute carrier family 6 member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc6a4 (solute carrier family 6 member 4)
Sus scrofa (pig) : SLC6A4 (solute carrier family 6 member 4)
Chlorocebus sabaeus (African green monkey) : SLC6A4 (solute carrier family 6 member 4)
Heterocephalus glaber (naked mole-rat) : Slc6a4 (solute carrier family 6 member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1730,194,319 - 30,236,002 (-)EnsemblGRCh38hg38GRCh38
GRCh381730,194,319 - 30,235,697 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371728,521,337 - 28,562,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361725,549,032 - 25,586,841 (-)NCBINCBI36hg18NCBI36
Build 341725,549,031 - 25,586,831NCBI
Celera1725,385,103 - 25,424,627 (-)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1724,731,684 - 24,773,327 (-)NCBIHuRef
CHM1_11728,583,810 - 28,625,471 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLC6A4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732932
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.