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Gene: HTR2C (5-hydroxytryptamine receptor 2C) Homo sapiens
Symbol: HTR2C
Name: 5-hydroxytryptamine receptor 2C
Description: Exhibits several functions, including 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; Gq/11-coupled serotonin receptor activity; and serotonin binding activity. Involved in several processes, including cGMP-mediated signaling; positive regulation of phosphate metabolic process; and serotonin receptor signaling pathway. Localizes to the integral component of plasma membrane. Implicated in bipolar disorder; obesity; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor-1c; 5HTR2C; HTR1C; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; serotonin receptor 2C
Mus musculus (house mouse) : Htr2c (5-hydroxytryptamine (serotonin) receptor 2C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Htr2c (5-hydroxytryptamine receptor 2C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htr2c (5-hydroxytryptamine receptor 2C)
Pan paniscus (bonobo/pygmy chimpanzee) : HTR2C (5-hydroxytryptamine receptor 2C)
Canis lupus familiaris (dog) : HTR2C (5-hydroxytryptamine receptor 2C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htr2c (5-hydroxytryptamine receptor 2C)
Sus scrofa (pig) : HTR2C (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X114,584,078 - 114,910,061 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X113,818,551 - 114,144,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X113,724,807 - 114,050,880 (+)NCBINCBI36hg18NCBI36
Build 34X113,641,530 - 113,967,604NCBI
CeleraX114,253,715 - 114,579,778 (+)NCBI
Cytogenetic MapXq23NCBI
HuRefX103,403,272 - 103,731,741 (+)NCBIHuRef
CHM1_1X113,729,484 - 114,055,500 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HTR2C
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736842
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.