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Gene: HDAC5 (histone deacetylase 5) Homo sapiens
Symbol: HDAC5
Name: histone deacetylase 5
Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen NY-CO-9; FLJ90614; HD5; NY-CO-9
Mus musculus (house mouse) : Hdac5 (histone deacetylase 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdac5 (histone deacetylase 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac5 (histone deacetylase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC5 (histone deacetylase 5)
Canis lupus familiaris (dog) : HDAC5 (histone deacetylase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac5 (histone deacetylase 5)
Sus scrofa (pig) : HDAC5 (histone deacetylase 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381744,076,753 - 44,123,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371742,154,121 - 42,201,014 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,509,647 - 39,556,540 (-)NCBINCBI36hg18NCBI36
Celera1738,862,215 - 38,909,110 (-)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1737,918,049 - 37,965,007 (-)NCBIHuRef
CHM1_11742,389,491 - 42,436,420 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HDAC5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1604649
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.