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Gene: HDAC5 (histone deacetylase 5) Homo sapiens
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Symbol: HDAC5
Name: histone deacetylase 5
Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen NY-CO-9; FLJ90614; HD5; NY-CO-9
Orthologs:
Mus musculus (house mouse) : Hdac5 (histone deacetylase 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdac5 (histone deacetylase 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac5 (histone deacetylase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC5 (histone deacetylase 5)
Canis lupus familiaris (dog) : HDAC5 (histone deacetylase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac5 (histone deacetylase 5)
Sus scrofa (pig) : HDAC5 (histone deacetylase 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,076,753 - 44,123,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371742,154,121 - 42,201,014 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,509,647 - 39,556,540 (-)NCBINCBI36hg18NCBI36
Celera1738,862,215 - 38,909,110 (-)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1737,918,049 - 37,965,007 (-)NCBIHuRef
CHM1_11742,389,491 - 42,436,420 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HDAC5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1604649
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.