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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:adrenergic uptake inhibitor
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Accession:CHEBI:35640 term browser browse the term
Definition:Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Synonyms:related_synonym: ARI;   NERI;   NRI;   adrenergic reuptake inhibitor;   adrenergic reuptake inhibitors;   adrenergic uptake inhibitors;   norepinephrine reuptake inhibitor;   norepinephrine reuptake inhibitors


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19791
    role 19738
      biological role 19738
        pharmacological role 18794
          neurotransmitter agent 16422
            adrenergic agent 8935
              adrenergic uptake inhibitor 4685
                (R,R)-tramadol + 25
                (R,R)-tramadol hydrochloride + 0
                (S)-amphetamine + 3470
                (S,S)-tramadol + 25
                (S,S)-tramadol hydrochloride + 0
                amezinium + 0
                amezinium metilsulfate 0
                amitriptyline + 185
                amoxapine 7
                amphetamine + 2202
                atomoxetine + 1
                atomoxetine hydrochloride 1
                benzphetamine + 1
                benzphetamine hydrochloride 0
                cocaine 1429
                desipramine + 45
                imipramine + 123
                methylphenidate 127
                mianserin + 17
                nefopam 1
                nefopam hydrochloride 0
                nisoxetine 2
                nortriptyline 20
                reserpine 116
                tetrabenazine 2
                tramadol 25
                tramadol hydrochloride 0
                venlafaxine + 175
Path 2
Term Annotations click to browse term
  CHEBI ontology 19791
    role 19738
      application 19397
        pharmaceutical 19270
          drug 19270
            neurotransmitter agent 16422
              adrenergic agent 8935
                adrenergic uptake inhibitor 4685
                  (R,R)-tramadol + 25
                  (R,R)-tramadol hydrochloride + 0
                  (S)-amphetamine + 3470
                  (S,S)-tramadol + 25
                  (S,S)-tramadol hydrochloride + 0
                  amezinium + 0
                  amezinium metilsulfate 0
                  amitriptyline + 185
                  amoxapine 7
                  amphetamine + 2202
                  atomoxetine + 1
                  atomoxetine hydrochloride 1
                  benzphetamine + 1
                  benzphetamine hydrochloride 0
                  cocaine 1429
                  desipramine + 45
                  imipramine + 123
                  methylphenidate 127
                  mianserin + 17
                  nefopam 1
                  nefopam hydrochloride 0
                  nisoxetine 2
                  nortriptyline 20
                  reserpine 116
                  tetrabenazine 2
                  tramadol 25
                  tramadol hydrochloride 0
                  venlafaxine + 175
paths to the root

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