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Gene: HTR1A (5-hydroxytryptamine receptor 1A) Homo sapiens

Analyze

Symbol:

HTR1A

Name:

5-hydroxytryptamine receptor 1A

RGD ID:

69020

HGNC Page

HGNC:5286

Description:

Enables Gi/o-coupled serotonin receptor activity; receptor-receptor interaction; and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. Implicated in alcohol dependence; anxiety disorder (multiple); depressive disorder; substance abuse; and withdrawal disorder. Biomarker of Alzheimer's disease; alcohol dependence; and depressive disorder.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

5-HT-1A; 5-HT1A; 5-HT1a receptor; 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; 5HT1a; ADRB2RL1; ADRBRL1; G protein coupled receptor; G-21; guanine nucleotide-binding regulatory protein-coupled receptor; PFMCD; serotonin receptor 1A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Htr1a (5-hydroxytryptamine (serotonin) receptor 1A)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Htr1a (5-hydroxytryptamine receptor 1A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Htr1a (5-hydroxytryptamine receptor 1A)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	HTR1A (5-hydroxytryptamine receptor 1A)	NCBI	Ortholog
Canis lupus familiaris (dog):	HTR1A (5-hydroxytryptamine receptor 1A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Htr1a (5-hydroxytryptamine receptor 1A)	NCBI	Ortholog
Sus scrofa (pig):	HTR1A (5-hydroxytryptamine receptor 1A)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	HTR1A (5-hydroxytryptamine receptor 1A)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Htr1a (5-hydroxytryptamine receptor 1A)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Htr1a (5-hydroxytryptamine receptor 1A)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Htr1a (5-hydroxytryptamine (serotonin) receptor 1A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	htr1aa (5-hydroxytryptamine (serotonin) receptor 1A a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid\|ZFIN)
Danio rerio (zebrafish):	htr1ab (5-hydroxytryptamine (serotonin) receptor 1A b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB\|ZFIN)
Drosophila melanogaster (fruit fly):	5-HT1A	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ser-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	5-HT1B	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	htr1a.S	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	htr1a	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	htr1a.L	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	63,957,874 - 63,962,445 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	63,957,874 - 63,962,507 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	63,253,701 - 63,258,272 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	63,292,034 - 63,293,302 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	63,292,033 - 63,293,302	NCBI
Celera	5	60,253,209 - 60,254,477 (-)	NCBI		Celera
Cytogenetic Map	5	q12.3	NCBI
HuRef	5	60,210,553 - 60,212,797 (-)	NCBI		HuRef
CHM1_1	5	63,255,560 - 63,257,804 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	64,778,009 - 64,782,580 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol dependence (IAGP,IEP)

alcohol use disorder (ISO)

Alzheimer's disease (IEP)

anxiety disorder (IAGP,ISO,ISS)

Apnea (EXP)

Bradycardia (EXP)

Catalepsy (ISO)

cocaine abuse (ISO)

Cocaine-Related Disorders (EXP)

depressive disorder (IAGP,IEP)

Drug-Induced Dyskinesia (ISO)

Fever (EXP)

learning disability (EXP)

Memory Disorders (EXP,ISO)

Neuralgia (ISO)

Neurodevelopmental Disorders (IAGP)

nicotine dependence (ISO)

Pain (EXP,ISO)

panic disorder (IAGP,ISO)

Parkinson's disease (ISO)

Periodic Fever, Menstrual Cycle-Dependent (IAGP)

Stomach Neoplasms (EXP)

subacute delirium (ISO)

substance abuse (IAGP)

substance-induced psychosis (EXP)

Tremor (EXP)

withdrawal disorder (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (ISO)

(S)-nicotine (ISO)

(Z)-chlorprothixene (EXP)

1-(3-chlorophenyl)piperazine (ISO)

1-bromopropane (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

3',5'-cyclic AMP (EXP)

3,5,6-trichloro-2-pyridinol (ISO)

3,5,6-trichloropyridine-2-one (ISO)

3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide (ISO)

3-phenoxybenzoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide hydrochloride (ISO)

5-carboxamidotryptamine (EXP,ISO)

8-OH-DPAT (EXP,ISO)

aflatoxin B1 (EXP)

albiflorin (ISO)

alverine (ISO)

amitriptyline (ISO)

ammonium chloride (ISO)

apocynin (ISO)

apomorphine (ISO)

arachidonic acid (EXP)

aripiprazole (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (EXP,ISO)

benzo[a]pyrene (EXP,ISO)

Bifeprunox (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bucladesine (EXP)

buspirone (EXP,ISO)

Butylbenzyl phthalate (ISO)

calcium atom (EXP)

calcium(0) (EXP)

cannabidiol (ISO)

cannabidiolic acid (EXP)

chlorpyrifos (ISO)

clofibrate (ISO)

clozapine (EXP,ISO)

cocaine (ISO)

colforsin daropate hydrochloride (EXP)

compound 48/80 (ISO)

Cuprizon (ISO)

curcumin (ISO)

cyhalothrin (ISO)

DDE (ISO)

DDT (ISO)

desipramine (EXP,ISO)

dexamethasone (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

dieldrin (ISO)

diethyl phthalate (ISO)

Diisodecyl phthalate (ISO)

doxepin (ISO)

ethanol (EXP,ISO)

etoperidone (EXP)

fluoxetine (EXP,ISO)

Gastrodin (ISO)

GDP (ISO)

GTP (ISO)

hydroquinone (ISO)

imipramine (ISO)

isotretinoin (ISO)

lipopolysaccharide (ISO)

loxapine (ISO)

lurasidone hydrochloride (EXP)

magnesium atom (ISO)

manganese atom (ISO)

manganese(0) (ISO)

medroxyprogesterone acetate (EXP)

melittin (EXP)

metformin (ISO)

methamidophos (ISO)

methamphetamine (EXP,ISO)

methiothepin (EXP,ISO)

methylphenidate (ISO)

morphine (ISO)

N,O-dimethyltyramine (ISO)

N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide (EXP,ISO)

naltrexone (ISO)

NAN 190 hydrobromide (EXP,ISO)

nefazodone (EXP)

nicotine (ISO)

nitrates (ISO)

ochratoxin A (ISO)

oxidopamine (ISO)

p-hydroxybenzyl alcohol (ISO)

parathion (ISO)

physostigmine (ISO)

pindolol (ISO)

reserpine (ISO)

risperidone (ISO)

rottlerin (ISO)

scopolamine (ISO)

serotonin (EXP,ISO)

sertraline (ISO)

sodium arsenite (ISO)

Soman (ISO)

spiperone (EXP,ISO)

streptozocin (ISO)

tacrolimus hydrate (ISO)

tertatolol (ISO)

thapsigargin (EXP)

titanium dioxide (ISO)

trazodone (EXP,ISO)

vortioxetine (EXP)

ziprasidone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting serotonin receptor signaling pathway (IBA,IDA,IEA,ISO)

behavioral fear response (IEA,ISS)

behavioral response to nicotine (ISO)

chemical synaptic transmission (IBA)

exploration behavior (IEA,ISS)

G protein-coupled receptor signaling pathway (IEA,IMP,TAS)

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (IBA)

G protein-coupled serotonin receptor signaling pathway (IEA)

gamma-aminobutyric acid signaling pathway (IEA,ISO)

negative regulation of gamma-aminobutyric acid secretion (ISO)

NMDA glutamate receptor clustering (ISO)

positive regulation of cell population proliferation (TAS)

positive regulation of microtubule depolymerization (ISO)

presynaptic modulation of chemical synaptic transmission (ISO)

regulation of behavior (IEA)

regulation of dopamine metabolic process (IEA,ISS)

regulation of feeding behavior (ISO)

regulation of hormone secretion (IEA)

regulation of serotonin secretion (IEA,ISS)

regulation of vasoconstriction (IEA)

response to alcohol (ISO)

response to glycoside (ISO)

response to morphine (ISO)

serotonin metabolic process (IEA,ISS)

serotonin receptor signaling pathway (IEA,ISO,ISS)

vocalization behavior (ISO)

Cellular Component

axon hillock (ISO)

cell projection (IEA)

dendrite (IBA,IEA)

GABA-ergic synapse (ISO)

neuronal cell body (ISO)

plasma membrane (IBA,IDA,IEA,TAS)

presynaptic membrane (ISO)

synapse (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

G protein-coupled serotonin receptor activity (IBA,IDA,IEA,IMP,ISO,TAS)

G-protein alpha-subunit binding (ISO)

Gi/o-coupled serotonin receptor activity (IDA,IEA)

neurotransmitter receptor activity (IBA)

protein binding (IPI,ISO)

receptor-receptor interaction (IDA)

serotonin binding (IBA,ISO)

serotonin receptor activity (IDA,IEA)

signaling receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alfentanil pharmacodynamics pathway (EXP)

bupivacaine pharmacodynamics pathway (EXP)

buprenorphine pharmacodynamics pathway (EXP)

chloroprocaine pharmacodynamics pathway (EXP)

citalopram pharmacodynamics pathway (EXP)

cocaine pharmacodynamics pathway (EXP)

codeine and morphine pharmacodynamics pathway (EXP)

desipramine pharmacodynamics pathway (EXP)

diphenoxylate pharmacodynamics pathway (EXP)

escitalopram pharmacodynamics pathway (EXP)

ethylmorphine pharmacodynamics pathway (EXP)

fentanyl pharmacodynamics pathway (EXP)

fluoxetine pharmacodynamics pathway (EXP)

heroin pharmacodynamics pathway (EXP)

hydrocodone pharmacodynamics pathway (EXP)

hydromorphone pharmacodynamics pathway (EXP)

imipramine pharmacodynamics pathway (EXP)

levacetylmethadol pharmacodynamics pathway (EXP)

levobupivacaine phgarmacodynamics pathway (EXP)

levorphanol pharmacodynamics pathway (EXP)

lidocaine pharmacodynamics pathway (EXP)

mepivacaine pharmacodynamics pathway (EXP)

methadone pharmacodynamics pathway (EXP)

nalbuphine pharmacodynamics pathway (EXP)

naloxone pharmacodynamics pathway (EXP)

naltrexone pharmacodynamics pathway (EXP)

nicotine pharmacodynamics pathway (EXP)

oxybuprocaine pharmacodynamics pathway (EXP)

oxycodone pharmacodynamics pathway (EXP)

oxymorphone pharmacodynamics pathway (EXP)

pentazocine pharmacodynamics pathway (EXP)

prilocaine pharmacodynamics pathway (EXP)

procaine pharmacodynamics pathway (EXP)

remifentanil pharmacodynamics pathway (EXP)

ropivacaine pharmacodynamics pathway (EXP)

tramadol pharmacodynamics pathway (EXP)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Autosomal dominant inheritance (IAGP)

Fever (IAGP)

Increased circulating cortisol level (IAGP)

Migraine (IAGP)

Recurrent spontaneous abortion (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting.	Blaya C, etal., Neurosci Lett. 2010 Nov 12;485(1):11-5. Epub 2010 Sep 15.
2.	Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling.	Chen WC, etal., J Ethnopharmacol. 2016 Apr 22;182:190-9. doi: 10.1016/j.jep.2016.02.001. Epub 2016 Feb 16.
3.	The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription.	Donaldson ZR, etal., Transl Psychiatry. 2016 Mar 1;6:e746. doi: 10.1038/tp.2015.226.
4.	PET imaging of serotonin 1A receptor binding in depression.	Drevets WC, etal., Biol Psychiatry. 1999 Nov 15;46(10):1375-87.
5.	Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rats.	Dupre KB, etal., Exp Neurol. 2011 Jun;229(2):288-99. Epub 2011 Feb 22.
6.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
7.	Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.	Heisler LK, etal., Proc Natl Acad Sci U S A 1998 Dec 8;95(25):15049-54.
8.	Clinical manifestation of alcohol withdrawal symptoms related to genetic polymorphisms of two serotonin receptors and serotonin transporter.	Lee YS, etal., Eur Addict Res. 2009;15(1):39-46. doi: 10.1159/000173008. Epub 2008 Dec 2.
9.	5-HT1A autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain.	Li Y, etal., Neuroreport. 2019 Jun 12;30(9):681-687. doi: 10.1097/WNR.0000000000001260.
10.	Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of β-arrestin2.	Luessen DJ, etal., J Biol Chem. 2019 Sep 20;294(38):14068-14080. doi: 10.1074/jbc.RA118.006583. Epub 2019 Jul 31.
11.	Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus.	Lunden JW and Kirby LG, Neuroscience. 2013 Dec 19;254:160-72. doi: 10.1016/j.neuroscience.2013.08.071. Epub 2013 Sep 20.
12.	Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats.	Mannucci C, etal., Phytomedicine. 2012 Sep 15;19(12):1117-24. doi: 10.1016/j.phymed.2012.07.001. Epub 2012 Aug 24.
13.	Polymorphic variation at the serotonin 1-A receptor gene is associated with comorbid depression and generalized anxiety.	Molina E, etal., Psychiatr Genet. 2011 Aug;21(4):195-201.
14.	Buspirone improves 6-hydroxydopamine-induced catalepsy through stimulation of nigral 5-HT(1A) receptors in rats.	Nayebi AM, etal., Pharmacol Rep. 2010 Mar-Apr;62(2):258-64.
15.	5-HT1A and α2 adrenergic receptor levels are associated with high anxiety-like patterns and impulsivity in selectively bred Long Evans rats.	Niedzielak T, etal., Behav Brain Res. 2020 Apr 6;383:112522. doi: 10.1016/j.bbr.2020.112522. Epub 2020 Jan 30.
16.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
17.	Downregulation of 5-HT1A receptors in rat hypothalamus and dentate gyrus after "binge" pattern cocaine administration.	Perret G, etal., Synapse. 1998 Oct;30(2):166-71. doi: 10.1002/(SICI)1098-2396(199810)30:2<166::AID-SYN6>3.0.CO;2-A.
18.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
19.	Receptor-genes cross-talk: effect of chronic 5-HT(1A) agonist 8-hydroxy-2-(di-n-propylamino) tetralin treatment on the expression of key genes in brain serotonin system and on behavior.	Popova NK, etal., Neuroscience. 2010 Aug 11;169(1):229-35. doi: 10.1016/j.neuroscience.2010.04.044. Epub 2010 Apr 25.
20.	Neuroprotective effects of HTR1A antagonist WAY-100635 on scopolamine-induced delirium in rats and underlying molecular mechanisms.	Qiu Y, etal., BMC Neurosci. 2016 Oct 19;17(1):66. doi: 10.1186/s12868-016-0300-9.
21.	Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.	Ramboz S, etal., Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14476-81.
22.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
24.	RGD HPO Phenotype Annotation Pipeline	RGD automated import pipeline for human HPO-to-gene-to-disease annotations
25.	Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol.	Roberts AJ, etal., Psychopharmacology (Berl). 1998 May;137(1):25-32. doi: 10.1007/s002130050589.
26.	Repeated administration of methylphenidate produces reinforcement and downregulates 5-HT-1A receptor expression in the nucleus accumbens.	Salman T, etal., Life Sci. 2019 Feb 1;218:139-146. doi: 10.1016/j.lfs.2018.12.046. Epub 2018 Dec 27.
27.	Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze.	Sela VR, etal., Neurosci Lett. 2011 May 9;495(1):63-6. Epub 2011 Mar 21.
28.	Serotonin receptor, SERT mRNA and correlations with symptoms in males with alcohol dependence and suicide.	Thompson PM, etal., Acta Psychiatr Scand. 2012 Sep;126(3):165-74. doi: 10.1111/j.1600-0447.2011.01816.x. Epub 2011 Dec 19.
29.	Ameliorative effect of gastrodin on 3,3'-iminodipropionitrile-induced memory impairment in rats.	Wang X, etal., Neurosci Lett. 2015 May 6;594:40-5. doi: 10.1016/j.neulet.2015.03.049. Epub 2015 Mar 26.
30.	Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control age-matched and Alzheimer individuals.	Yeung LY, etal., Age (Dordr). 2010 Dec;32(4):483-95. Epub 2010 May 28.
31.	Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: Descending monoamine system and opioid receptors are differentially involved.	Zhao X, etal., Neuropharmacology. 2011 Sep 19.
32.	Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.	Zuo L, etal., Alcohol Clin Exp Res. 2013 May;37(5):730-9. doi: 10.1111/acer.12032. Epub 2012 Dec 6.

Additional References at PubMed

PMID:1330092	PMID:1559993	PMID:1685484	PMID:1766875	PMID:2052135	PMID:2591972	PMID:2834384	PMID:3041227	PMID:3138543	PMID:7755630	PMID:8218170	PMID:8393041
PMID:8626793	PMID:9736659	PMID:9754630	PMID:11140838	PMID:11163544	PMID:11814436	PMID:11854302	PMID:11989622	PMID:11992564	PMID:12062903	PMID:12181435	PMID:12477932
PMID:12522576	PMID:12559389	PMID:12650852	PMID:12759158	PMID:12969265	PMID:14507979	PMID:14573316	PMID:14666415	PMID:14736842	PMID:14744462	PMID:14984628	PMID:14998306
PMID:15048689	PMID:15052272	PMID:15111672	PMID:15148501	PMID:15211620	PMID:15447813	PMID:15458611	PMID:15469667	PMID:15489334	PMID:15498580	PMID:15521063	PMID:15539859
PMID:15683551	PMID:15716853	PMID:15728438	PMID:15758168	PMID:15864118	PMID:15940302	PMID:15952185	PMID:16081372	PMID:16154547	PMID:16302021	PMID:16316476	PMID:16344560
PMID:16458487	PMID:16464220	PMID:16467535	PMID:16504134	PMID:16538182	PMID:16626484	PMID:16633140	PMID:16677618	PMID:16722981	PMID:16756688	PMID:16770336	PMID:16856120
PMID:17009264	PMID:17012696	PMID:17092965	PMID:17123166	PMID:17142836	PMID:17192951	PMID:17203304	PMID:17203973	PMID:17208318	PMID:17217240	PMID:17401528	PMID:17408646
PMID:17417740	PMID:17420412	PMID:17426452	PMID:17438519	PMID:17466494	PMID:17493586	PMID:17504248	PMID:17507923	PMID:17540717	PMID:17543959	PMID:17570737	PMID:17655760
PMID:17661792	PMID:17724868	PMID:17888419	PMID:17906010	PMID:18047755	PMID:18079067	PMID:18163385	PMID:18181968	PMID:18240029	PMID:18268499	PMID:18270970	PMID:18286597
PMID:18308786	PMID:18334271	PMID:18387137	PMID:18387740	PMID:18394726	PMID:18484082	PMID:18561871	PMID:18562131	PMID:18573276	PMID:18577758	PMID:18583156	PMID:18593952
PMID:18606193	PMID:18639564	PMID:18644006	PMID:18663369	PMID:18675780	PMID:18706198	PMID:18707693	PMID:18715570	PMID:18727636	PMID:18761712	PMID:18796187	PMID:18826444
PMID:18832011	PMID:18841018	PMID:18848359	PMID:18849890	PMID:18855532	PMID:18937842	PMID:18962444	PMID:18971477	PMID:18982004	PMID:19032968	PMID:19052756	PMID:19077664
PMID:19086022	PMID:19086053	PMID:19095219	PMID:19105200	PMID:19124686	PMID:19156168	PMID:19162119	PMID:19170664	PMID:19224112	PMID:19278673	PMID:19309202	PMID:19326813
PMID:19330775	PMID:19339052	PMID:19352591	PMID:19353636	PMID:19381154	PMID:19423080	PMID:19439818	PMID:19455600	PMID:19533293	PMID:19560507	PMID:19590397	PMID:19617338
PMID:19636338	PMID:19639876	PMID:19723504	PMID:19725031	PMID:19730445	PMID:19736291	PMID:19747927	PMID:19780043	PMID:19781522	PMID:19800133	PMID:19829169	PMID:19874574
PMID:19894072	PMID:19897250	PMID:19900711	PMID:19903365	PMID:19936617	PMID:19962444	PMID:19997044	PMID:20010450	PMID:20022223	PMID:20025927	PMID:20026342	PMID:20043001
PMID:20075642	PMID:20124538	PMID:20170167	PMID:20171159	PMID:20351714	PMID:20388441	PMID:20392296	PMID:20403354	PMID:20435093	PMID:20451351	PMID:20453658	PMID:20454985
PMID:20468064	PMID:20470849	PMID:20515362	PMID:20519060	PMID:20521763	PMID:20533011	PMID:20538346	PMID:20577624	PMID:20594600	PMID:20609217	PMID:20633049	PMID:20638825
PMID:20734064	PMID:20935630	PMID:21169892	PMID:21194755	PMID:21214634	PMID:21269332	PMID:21382916	PMID:21397953	PMID:21399903	PMID:21449006	PMID:21453976	PMID:21459095
PMID:21577007	PMID:21605442	PMID:21619616	PMID:21621273	PMID:21640070	PMID:21645534	PMID:21688171	PMID:21726540	PMID:21750580	PMID:21849982	PMID:21873635	PMID:22035699
PMID:22044630	PMID:22050514	PMID:22111663	PMID:22120873	PMID:22205572	PMID:22222329	PMID:22232550	PMID:22328058	PMID:22373128	PMID:22392387	PMID:22403020	PMID:22483975
PMID:22491354	PMID:22493371	PMID:22510520	PMID:22560877	PMID:22563461	PMID:22579604	PMID:22594670	PMID:22624739	PMID:22752684	PMID:22836176	PMID:22863653	PMID:22892071
PMID:22952650	PMID:22957663	PMID:23006663	PMID:23036158	PMID:23192369	PMID:23247084	PMID:23277246	PMID:23308375	PMID:23318131	PMID:23333373	PMID:23375453	PMID:23408467
PMID:23434290	PMID:23466604	PMID:23495896	PMID:23499153	PMID:23516322	PMID:23537781	PMID:23809646	PMID:23844689	PMID:23894004	PMID:23897914	PMID:23907404	PMID:23911056
PMID:24050112	PMID:24157794	PMID:24158751	PMID:24204828	PMID:24292102	PMID:24331356	PMID:24429872	PMID:24440118	PMID:24460115	PMID:24462335	PMID:24657886	PMID:24935787
PMID:24972638	PMID:25188405	PMID:25247748	PMID:25304920	PMID:25412229	PMID:25446224	PMID:25448266	PMID:25472558	PMID:25485703	PMID:25514753	PMID:25560469	PMID:25649022
PMID:25822479	PMID:25850571	PMID:26001668	PMID:26079129	PMID:26261165	PMID:26342283	PMID:26365466	PMID:26408209	PMID:26544898	PMID:26568455	PMID:26609890	PMID:26782176
PMID:26845861	PMID:26866771	PMID:27276266	PMID:27552916	PMID:27661418	PMID:27756686	PMID:27897266	PMID:27939355	PMID:27984018	PMID:28027114	PMID:28109756	PMID:28282362
PMID:28470485	PMID:28590587	PMID:28608854	PMID:28793232	PMID:28920103	PMID:28970569	PMID:29045584	PMID:29275155	PMID:29323797	PMID:29363117	PMID:29430989	PMID:29661255
PMID:29709878	PMID:30021884	PMID:30093565	PMID:30232922	PMID:30266578	PMID:30476041	PMID:30552318	PMID:30664620	PMID:30807072	PMID:31120232	PMID:31228794	PMID:31264537
PMID:31291234	PMID:31477731	PMID:31614865	PMID:31636356	PMID:31847007	PMID:32864880	PMID:33350992	PMID:33429076	PMID:33567384	PMID:33760584	PMID:33762731	PMID:33874644
PMID:35019025	PMID:35199941	PMID:35467841	PMID:35608952	PMID:35610220	PMID:36214900	PMID:36533718	PMID:36691786	PMID:36724073	PMID:36769290	PMID:36980311	PMID:37161455
PMID:37323077	PMID:37473654	PMID:37525034	PMID:37567783	PMID:37935376	PMID:37935377	PMID:37958600	PMID:37984468	PMID:38906512	PMID:39207450

Genomics

Comparative Map Data

HTR1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	63,957,874 - 63,962,445 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	63,957,874 - 63,962,507 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	63,253,701 - 63,258,272 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	63,292,034 - 63,293,302 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	63,292,033 - 63,293,302	NCBI
Celera	5	60,253,209 - 60,254,477 (-)	NCBI		Celera
Cytogenetic Map	5	q12.3	NCBI
HuRef	5	60,210,553 - 60,212,797 (-)	NCBI		HuRef
CHM1_1	5	63,255,560 - 63,257,804 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	64,778,009 - 64,782,580 (-)	NCBI		T2T-CHM13v2.0

Htr1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	105,580,040 - 105,584,630 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	105,580,147 - 105,584,630 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	105,443,693 - 105,448,133 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	105,443,639 - 105,448,122 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	106,233,773 - 106,238,213 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	106,564,148 - 106,568,501 (+)	NCBI		MGSCv36	mm8
Celera	13	109,835,550 - 109,839,989 (+)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	56.92	NCBI

Htr1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	38,427,169 - 38,431,733 (+)	NCBI		GRCr8
mRatBN7.2	2	36,693,462 - 36,698,026 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	36,694,174 - 36,695,442 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	43,823,087 - 43,824,355 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	41,881,727 - 41,882,995 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	36,737,009 - 36,738,277 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	36,246,628 - 36,247,896 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	36,246,628 - 36,247,896 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	55,362,662 - 55,363,930 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	36,434,518 - 36,435,786 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	36,354,886 - 36,356,155 (+)	NCBI
Celera	2	32,636,756 - 32,638,024 (+)	NCBI		Celera
RH 3.4 Map	2	156.5	RGD
Cytogenetic Map	2	q13	NCBI

Htr1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	4,913,884 - 4,915,146 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955446	4,913,181 - 4,917,726 (+)	NCBI	ChiLan1.0	ChiLan1.0

HTR1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	49,960,948 - 49,964,784 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	48,114,114 - 48,118,414 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	50,045,266 - 50,049,636 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	51,691,853 - 51,696,257 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	51,692,416 - 51,693,684 (+)	Ensembl	panpan1.1		panPan2

HTR1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	50,005,277 - 50,006,548 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	50,002,740 - 50,006,548 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	46,962,303 - 46,963,574 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	50,490,014 - 50,491,285 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	2	47,550,689 - 47,551,960 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	48,341,999 - 48,343,270 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	49,236,031 - 49,237,302 (-)	NCBI		UU_Cfam_GSD_1.0

Htr1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	196,105,986 - 196,110,702 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	5,043,204 - 5,044,472 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	5,042,531 - 5,047,157 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HTR1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	42,478,923 - 42,484,304 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	42,479,812 - 42,484,365 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	45,547,917 - 45,550,733 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HTR1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	60,159,542 - 60,162,947 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	60,159,944 - 60,161,212 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	8,232,890 - 8,758,394 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Htr1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624815	5,816,601 - 5,820,864 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624815	5,817,196 - 5,821,197 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in HTR1A
35 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
NM_000524.4(HTR1A):c.-480del	deletion	Menstrual cycle-dependent periodic fever [RCV000024351]\|not provided [RCV003430640]\|not specified [RCV002247394]	Chr5:63962199 [GRCh38] Chr5:63258026 [GRCh37] Chr5:5q12.3	pathogenic\|likely benign\|uncertain significance
GRCh38/hg38 5q12.1-13.2(chr5:63207112-71291191)x3	copy number gain	See cases [RCV000135640]	Chr5:63207112..71291191 [GRCh38] Chr5:62502939..70587018 [GRCh37] Chr5:62538695..70622774 [NCBI36] Chr5:5q12.1-13.2	likely pathogenic
GRCh38/hg38 5p15.33-q13.3(chr5:22149-74412725)x3	copy number gain	See cases [RCV000138780]	Chr5:22149..74412725 [GRCh38] Chr5:22149..73708550 [GRCh37] Chr5:75149..73744306 [NCBI36] Chr5:5p15.33-q13.3	pathogenic
GRCh38/hg38 5q12.2-12.3(chr5:63826033-64429460)x3	copy number gain	See cases [RCV000141875]	Chr5:63826033..64429460 [GRCh38] Chr5:63121860..63725287 [GRCh37] Chr5:63157616..63761043 [NCBI36] Chr5:5q12.2-12.3	uncertain significance
NM_000524.3(HTR1A):c.-1019G>G	single nucleotide variant	not specified [RCV000611090]	Chr5:63962738 [GRCh38] Chr5:63258565 [GRCh37] Chr5:5q12.3	benign\|drug response
GRCh37/hg19 5q12.1-12.3(chr5:59783655-63257950)x1	copy number loss	See cases [RCV002285073]	Chr5:59783655..63257950 [GRCh37] Chr5:5q12.1-12.3	pathogenic
GRCh37/hg19 5q12.1-13.2(chr5:60722469-70792199)x1	copy number loss	See cases [RCV000447549]	Chr5:60722469..70792199 [GRCh37] Chr5:5q12.1-13.2	pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)	copy number gain	See cases [RCV000510723]	Chr5:113577..180719789 [GRCh37] Chr5:5p15.33-q35.3	pathogenic
NM_000524.3(HTR1A):c.-1019G>C	single nucleotide variant	not specified [RCV000603722]	Chr5:63962738 [GRCh38] Chr5:63258565 [GRCh37] Chr5:5q12.3	likely benign\|drug response
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1	copy number loss	See cases [RCV000511978]	Chr5:17628741..176575720 [GRCh37] Chr5:5p15.1-q35.2	pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3	copy number gain	See cases [RCV000512039]	Chr5:113577..180719789 [GRCh37] Chr5:5p15.33-q35.3	pathogenic
GRCh37/hg19 5q12.1-12.3(chr5:59753805-63274635)x1	copy number loss	See cases [RCV000511984]	Chr5:59753805..63274635 [GRCh37] Chr5:5q12.1-12.3	uncertain significance
GRCh37/hg19 5q12.1-13.2(chr5:58966132-68847066)x4	copy number gain	See cases [RCV000510792]	Chr5:58966132..68847066 [GRCh37] Chr5:5q12.1-13.2	likely pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3	copy number gain	not provided [RCV000744317]	Chr5:13648..180905029 [GRCh37] Chr5:5p15.33-q35.3	pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3	copy number gain	not provided [RCV000744323]	Chr5:25328..180693344 [GRCh37] Chr5:5p15.33-q35.3	pathogenic
Single allele	deletion	Neurodevelopmental disorder [RCV000787436]	Chr5:14685137..149511942 [GRCh37] Chr5:5p15.2-q32	uncertain significance
NM_000524.4(HTR1A):c.82A>G (p.Ile28Val)	single nucleotide variant	not provided [RCV000951076]	Chr5:63961638 [GRCh38] Chr5:63257465 [GRCh37] Chr5:5q12.3	benign
NM_000524.4(HTR1A):c.861C>T (p.Gly287=)	single nucleotide variant	not provided [RCV000981244]	Chr5:63960859 [GRCh38] Chr5:63256686 [GRCh37] Chr5:5q12.3	likely benign
NM_000524.4(HTR1A):c.96C>G (p.Thr32=)	single nucleotide variant	not provided [RCV000883045]	Chr5:63961624 [GRCh38] Chr5:63257451 [GRCh37] Chr5:5q12.3	likely benign
NM_000524.4(HTR1A):c.545C>T (p.Ser182Leu)	single nucleotide variant	not provided [RCV000899353]	Chr5:63961175 [GRCh38] Chr5:63257002 [GRCh37] Chr5:5q12.3	benign\|likely benign
NM_000524.4(HTR1A):c.423C>T (p.Pro141=)	single nucleotide variant	not provided [RCV000923259]	Chr5:63961297 [GRCh38] Chr5:63257124 [GRCh37] Chr5:5q12.3	benign
NM_000524.4(HTR1A):c.47C>T (p.Pro16Leu)	single nucleotide variant	not provided [RCV000885325]	Chr5:63961673 [GRCh38] Chr5:63257500 [GRCh37] Chr5:5q12.3	benign
NM_000524.4(HTR1A):c.464C>G (p.Ala155Gly)	single nucleotide variant	HTR1A-related disorder [RCV003943124]\|not provided [RCV000963012]	Chr5:63961256 [GRCh38] Chr5:63257083 [GRCh37] Chr5:5q12.3	likely benign
NM_000524.4(HTR1A):c.818G>A (p.Gly273Asp)	single nucleotide variant	not provided [RCV000960854]	Chr5:63960902 [GRCh38] Chr5:63256729 [GRCh37] Chr5:5q12.3	benign
NM_000524.4(HTR1A):c.465G>T (p.Ala155=)	single nucleotide variant	not provided [RCV000885761]	Chr5:63961255 [GRCh38] Chr5:63257082 [GRCh37] Chr5:5q12.3	likely benign
GRCh38/hg38 5q11.2-13.2(chr5:58785203-73519962)x1	copy number loss	Intellectual disability [RCV000984869]	Chr5:58785203..73519962 [GRCh38] Chr5:5q11.2-13.2	likely pathogenic
NC_000005.10:g.63965502C>T	single nucleotide variant	not provided [RCV001661025]	Chr5:63965502 [GRCh38] Chr5:63261329 [GRCh37] Chr5:5q12.3	benign
NM_000524.4(HTR1A):c.275T>C (p.Met92Thr)	single nucleotide variant	not provided [RCV001354346]	Chr5:63961445 [GRCh38] Chr5:63257272 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.659G>T (p.Arg220Leu)	single nucleotide variant	not provided [RCV001755417]	Chr5:63961061 [GRCh38] Chr5:63256888 [GRCh37] Chr5:5q12.3	benign\|likely benign
NC_000005.9:g.(?_63256278)_(65374358_?)del	deletion	not provided [RCV001970200]	Chr5:63256278..65374358 [GRCh37] Chr5:5q12.3	pathogenic
NM_000524.4(HTR1A):c.390C>A (p.Ile130=)	single nucleotide variant	not specified [RCV002222897]	Chr5:63961330 [GRCh38] Chr5:63257157 [GRCh37] Chr5:5q12.3	likely benign
NM_000524.4(HTR1A):c.1000A>C (p.Lys334Gln)	single nucleotide variant	not provided [RCV002276130]	Chr5:63960720 [GRCh38] Chr5:63256547 [GRCh37] Chr5:5q12.3	likely benign
NM_000524.4(HTR1A):c.295C>T (p.Leu99Phe)	single nucleotide variant	not specified [RCV004109796]	Chr5:63961425 [GRCh38] Chr5:63257252 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.674G>A (p.Arg225His)	single nucleotide variant	not specified [RCV004093176]	Chr5:63961046 [GRCh38] Chr5:63256873 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.416C>T (p.Thr139Met)	single nucleotide variant	not specified [RCV004160750]	Chr5:63961304 [GRCh38] Chr5:63257131 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.748C>T (p.Pro250Ser)	single nucleotide variant	not specified [RCV004093401]	Chr5:63960972 [GRCh38] Chr5:63256799 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.955G>A (p.Ala319Thr)	single nucleotide variant	not specified [RCV004128428]	Chr5:63960765 [GRCh38] Chr5:63256592 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.32A>C (p.Asn11Thr)	single nucleotide variant	not specified [RCV004071141]	Chr5:63961688 [GRCh38] Chr5:63257515 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.980_1039del (p.Arg327_Thr346del)	deletion	Menstrual cycle-dependent periodic fever [RCV003225791]	Chr5:63960681..63960740 [GRCh38] Chr5:63256508..63256567 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.902C>T (p.Ser301Phe)	single nucleotide variant	not specified [RCV004331129]	Chr5:63960818 [GRCh38] Chr5:63256645 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.753G>C (p.Lys251Asn)	single nucleotide variant	not specified [RCV004352889]	Chr5:63960967 [GRCh38] Chr5:63256794 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.709G>A (p.Gly237Arg)	single nucleotide variant	not provided [RCV003428527]	Chr5:63961011 [GRCh38] Chr5:63256838 [GRCh37] Chr5:5q12.3	likely benign
Single allele	deletion	not provided [RCV003448709]	Chr5:62757224..67825254 [GRCh37] Chr5:5q12.1-13.1	uncertain significance
NM_000524.4(HTR1A):c.858T>C (p.Asp286=)	single nucleotide variant	not provided [RCV003429654]	Chr5:63960862 [GRCh38] Chr5:63256689 [GRCh37] Chr5:5q12.3	likely benign
NM_000524.4(HTR1A):c.1002G>A (p.Lys334=)	single nucleotide variant	not provided [RCV003429653]	Chr5:63960718 [GRCh38] Chr5:63256545 [GRCh37] Chr5:5q12.3	likely benign
NM_000524.4(HTR1A):c.1015dup (p.Arg339fs)	duplication	not provided [RCV003884293]	Chr5:63960704..63960705 [GRCh38] Chr5:63256531..63256532 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.975T>C (p.Asn325=)	single nucleotide variant	HTR1A-related disorder [RCV003957255]	Chr5:63960745 [GRCh38] Chr5:63256572 [GRCh37] Chr5:5q12.3	likely benign
NM_000524.4(HTR1A):c.109G>A (p.Val37Met)	single nucleotide variant	not specified [RCV004404828]	Chr5:63961611 [GRCh38] Chr5:63257438 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.215A>G (p.Asn72Ser)	single nucleotide variant	not specified [RCV004404829]	Chr5:63961505 [GRCh38] Chr5:63257332 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.737C>A (p.Pro246His)	single nucleotide variant	not specified [RCV004404830]	Chr5:63960983 [GRCh38] Chr5:63256810 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.779G>A (p.Ser260Asn)	single nucleotide variant	not specified [RCV004404831]	Chr5:63960941 [GRCh38] Chr5:63256768 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.855C>G (p.Asp285Glu)	single nucleotide variant	not specified [RCV004404832]	Chr5:63960865 [GRCh38] Chr5:63256692 [GRCh37] Chr5:5q12.3	likely benign
NM_000524.4(HTR1A):c.889C>G (p.Arg297Gly)	single nucleotide variant	not specified [RCV004404833]	Chr5:63960831 [GRCh38] Chr5:63256658 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.928G>A (p.Glu310Lys)	single nucleotide variant	not specified [RCV004626294]	Chr5:63960792 [GRCh38] Chr5:63256619 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.1022G>A (p.Arg341Lys)	single nucleotide variant	not specified [RCV004626295]	Chr5:63960698 [GRCh38] Chr5:63256525 [GRCh37] Chr5:5q12.3	uncertain significance
NM_000524.4(HTR1A):c.730G>A (p.Ala244Thr)	single nucleotide variant	not specified [RCV004635303]	Chr5:63960990 [GRCh38] Chr5:63256817 [GRCh37] Chr5:5q12.3	likely benign
NM_000524.4(HTR1A):c.184G>T (p.Ala62Ser)	single nucleotide variant	not specified [RCV004635302]	Chr5:63961536 [GRCh38] Chr5:63257363 [GRCh37] Chr5:5q12.3	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	498
Count of miRNA genes:	416
Interacting mature miRNAs:	439
Transcripts:	ENST00000323865, ENST00000506598
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

HTR1A

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	5	63,256,731 - 63,256,831	UniSTS	GRCh37
Build 36	5	63,292,487 - 63,292,587	RGD	NCBI36
Celera	5	60,253,662 - 60,253,762	RGD
HuRef	5	60,211,409 - 60,211,509	UniSTS

RH70818

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	5	63,256,240 - 63,256,503	UniSTS	GRCh37
Build 36	5	63,291,996 - 63,292,259	RGD	NCBI36
Celera	5	60,253,171 - 60,253,434	RGD
Cytogenetic Map	5	q11.2-q13	UniSTS
HuRef	5	60,210,918 - 60,211,181	UniSTS
GeneMap99-GB4 RH Map	5	303.85	UniSTS

UniSTS:481605

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	5	63,256,278 - 63,257,546	UniSTS	GRCh37
Celera	5	60,253,209 - 60,254,477	UniSTS
HuRef	5	60,210,956 - 60,212,224	UniSTS

UniSTS:483224

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	5	63,256,256 - 63,257,636	UniSTS	GRCh37
Celera	5	60,253,187 - 60,254,567	UniSTS
HuRef	5	60,210,934 - 60,212,314	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system
58	149	199	413	2645	384	292	39	93	26	284	750	673	2369	74	693	243	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_032816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_000524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB041403	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC122707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF498978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ781317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK291429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK314187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC069159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC136263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA160783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA223047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA527925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M28269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M83181	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S64045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X13556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X57829	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z11168	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000323865 ⟹ ENSP00000316244

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	5	63,957,874 - 63,962,445 (-)	Ensembl

Ensembl Acc Id:

ENST00000506598 ⟹ ENSP00000423433

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	5	63,961,595 - 63,962,507 (-)	Ensembl

RefSeq Acc Id:

NM_000524 ⟹ NP_000515

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	5	63,957,874 - 63,962,445 (-)	NCBI
GRCh37	5	63,255,875 - 63,258,119 (-)	NCBI
Build 36	5	63,292,034 - 63,293,302 (-)	NCBI Archive
HuRef	5	60,210,553 - 60,212,797 (-)	NCBI
CHM1_1	5	63,255,560 - 63,257,804 (-)	NCBI
T2T-CHM13v2.0	5	64,778,009 - 64,782,580 (-)	NCBI

Sequence:

show sequence

GTTGACAAAAAGAGACTCGAATGCAAAGACGCTGAGCTAGAGGGAGAGGAGGGCGGGGACCCAG
AGGAAAGAGGCACTCCTCGGGGTTGGGGAAGTATTAGGAGGGGAGGGTTAGAGTGGGAGGGAAG
GAGCCTGGCTTTCGAAGCGACTCACAGAGGGATAAATAAAGGGAAGTGAGGAGGAAGAGGGAGA
CTGAAAGGGAAGGCAGGTGGGGAGAAGGGGGACGAAAGAGGCAGAAGAGAGAGAAGAGAGGAGG
AGAGAGGGGGAGAGAGGGAAGGAAGGAAATAGGGAGAGGAGGGTCACAGAGTGACCGTGGAGGA
TGGGGCTTCTCGGTTCTAGATATTTCTGGGATTGGAGACTGTTTGCTAGTGGGGAGACTCCAGC
TCCGGCAGCCAGTTCGGGAGCGGCAAAGTAAAATGGACAGCGACAGACAGACGTTCCAGCCACC
TCTCCGCCGCCGGGAGATCCTGGAGCTGCTTTCAGGCCAACTCCAGTTTCCCAGCTGGAGCTTC
TGAACGCGCTGGACTGCGAGAGCCCAGGGAGCGCCTGAAAGCTGCTCCTCGGAGATACCCTTCG
CCGAAGCAGTAAGAACTTCCTGCTTGGGTCTCTGCATTCCCTTCCTCCGAAACTTCCCAGGAGA
AGGGCGGAAGACCCCAGGGGAAGGGGCGAGGCGAATCTTCGCGCTGCTTTTTCTTCCCTCCCCC
TTCCCGCGCCGGGCGCGCAGGCATGGATGTGCTCAGCCCTGGTCAGGGCAACAACACCACATCA
CCACCGGCTCCCTTTGAGACCGGCGGCAACACTACTGGTATCTCCGACGTGACCGTCAGCTACC
AAGTGATCACCTCTCTGCTGCTGGGCACGCTCATCTTCTGCGCGGTGCTGGGCAATGCGTGCGT
GGTGGCTGCCATCGCCTTGGAGCGCTCCCTGCAGAACGTGGCCAATTATCTTATTGGCTCTTTG
GCGGTCACCGACCTCATGGTGTCGGTGTTGGTGCTGCCCATGGCCGCGCTGTATCAGGTGCTCA
ACAAGTGGACACTGGGCCAGGTAACCTGCGACCTGTTCATCGCCCTCGACGTGCTGTGCTGCAC
CTCATCCATCTTGCACCTGTGCGCCATCGCGCTGGACAGGTACTGGGCCATCACGGACCCCATC
GACTACGTGAACAAGAGGACGCCCCGGCGCGCCGCTGCGCTCATCTCGCTCACTTGGCTTATTG
GCTTCCTCATCTCTATCCCGCCCATGCTGGGCTGGCGCACCCCGGAAGACCGCTCGGACCCCGA
CGCATGCACCATTAGCAAGGATCATGGCTACACTATCTATTCCACCTTTGGAGCTTTCTACATC
CCGCTGCTGCTCATGCTGGTTCTCTATGGGCGCATATTCCGAGCTGCGCGCTTCCGCATCCGCA
AGACGGTCAAAAAGGTGGAGAAGACCGGAGCGGACACCCGCCATGGAGCATCTCCCGCCCCGCA
GCCCAAGAAGAGTGTGAATGGAGAGTCGGGGAGCAGGAACTGGAGGCTGGGCGTGGAGAGCAAG
GCTGGGGGTGCTCTGTGCGCCAATGGCGCGGTGAGGCAAGGTGACGATGGCGCCGCCCTGGAGG
TGATCGAGGTGCACCGAGTGGGCAACTCCAAAGAGCACTTGCCTCTGCCCAGCGAGGCTGGTCC
TACCCCTTGTGCCCCCGCCTCTTTCGAGAGGAAAAATGAGCGCAACGCCGAGGCGAAGCGCAAG
ATGGCCCTGGCCCGAGAGAGGAAGACAGTGAAGACGCTGGGCATCATCATGGGCACCTTCATCC
TCTGCTGGCTGCCCTTCTTCATCGTGGCTCTTGTTCTGCCCTTCTGCGAGAGCAGCTGCCACAT
GCCCACCCTGTTGGGCGCCATAATCAATTGGCTGGGCTACTCCAACTCTCTGCTTAACCCCGTC
ATTTACGCATACTTCAACAAGGACTTTCAAAACGCGTTTAAGAAGATCATTAAGTGTAAGTTCT
GCCGCCAGTGATGACGGAGGAGTAGCCGGCCAGTCGAGGCTACAGGATCCGTCCCATTCACTAT
GCTTCCCCCAACCCTAGGGAATCAACACTTAAGATAATTCGCCACTTCTCCTCTTTCTCTCTGC
TCCGCTCACGGCTTGCAGACCTGGTCCCCTCCCCACTTCCTGCTCCACGGCAGGGCCCTTTGTG
CAAAGGAGACCCAGCGGAGGAGCGTTGAGAGCCCAGGAAATTCAGAGAGTTTGTGAGAAGCGAC
ATTGGCTCAGACTTCGCCTGTATCATCAGTTTTGATCCCAGTAATTGCCTCTTCTCTCTTCTAT
CTCCTAAATCTTTGCGGTGGATGTTTAATGCTTAGTTCAAGGCAGAAAATCCAAAAAATAAATA
AACTGTACACACAGCCGCCGCGCCCACTAAGGGGCTCCACCCCATCACCCAACTTCTAGAACTT
GGACTTGAGGTTTGGGAATTTGCTCCATCTCTCCCGCCCTGTGGCCCTTGAAATATTCACCTTT
TTCTCCCCATTTTTATCTTTTCTTTTTTTCATTGCTTCCCTCTCTGCCCTCGCCCATCCTTATG
CACGAATCTGCTGGTCCGGAGAGGCGGAAGAGGCTGCTTTTCCCCGTGCCAGCGGTGCCCCCGG
GATTCCCCGTCTTCTCGCAGACTTGAGATTAACTCTCTCGTGCAGTGCACAACCCCTATTTCCT
TTGTTTCCTTGGACTCAAAGCAAGTGGCTAGAAGGTATCTTTTAGAGTGGACTTGTAAGTACAA
GGCCGGGCCAGTGGGGGAGAGCAAGGAGGAGGAGGGTGTGCAGACCACTTTGTTTATGCTTGCC
TTGGTGTCAGCACTCACCAAAGAAACTGACAATCATACAGTGGAGAGAGCGGACGCTGTTTGTA
CAGGTAGCTGGCGAGTGTGTACGACCTGACATCGCCACTTACTTACTGCGGGAGGCGCCAGCCG
GCCGCTGTTTGCGCTCTGGGGAAGCTGAGAGGCCTGGAATCCGCGCGCCTCCCCAGCCATCTGT
GCTCTCGCAGCGCGCTAGGCGCTCCCGGCTGCTGACTTACAGGATCTGGGTTCCTCCGCCTACG
CTCTGGGGCGCCCTGAAGCGCGGGTAGACACCTGAGGTTTTTGCCTTAGCCAGTGGCGCAAGAT
GCCGCGGAACTCTTGGGATTGGAGAGACCAAGAAGGCTTTAAAGGGGCGACACGCAGGGGCGGC
AAAGAGGAAAGGTTCCCCAGGGCGCGCGTGCCCAAGGCTCCAGCTGGCTCCCCCAGTAAAACCT
GAAAGAGCAATTTTATCCTTACGATGTAGAATTTTTCCTCCTAATTCACGCTCTTGTCCTTTTT
GGATCGGGGAATAATTCTGTTTAGCGTGTCCCAACACTCGCTGCATTTGCTTTACAGGACATCC
AAGACACAAAGTTAGCAGAACTTTGTTTTCCAAATAGGAATTCTGGGCTTTCAATGGAATGCCC
AGATAGTCCATAGGTTAGCACTATCTGTGACAACAGGCAGATAGTTTAAATAGCAGGGTCCTAA
AGGACTAGTTAGGAGGTGGTCTTCCTGGGGAGGCTGAGTCTTTTATGGGATTAATTGCTCCCTA
GCGTGACCATTCTGCTGTACCAAGGGTCTGCGGAAACCACCTTTTTGCCCTTTGAATTGTGCAG
CATTCCAGGCTTTCTCTCCTTCAGTTATTCTTGAAGCCTTGCCACTCCTGCCGAGAAACTGGTT
AAAATCTTTGCTGCCCCAGAAAGGGAAGTTATTTAGGTACTCTGGATGTAAATTTCCAACTACA
TGATGGAGATCTAGAGGTTTGTCATTGTTTGATCTAGCCTCCAATTTTCTTATGAATAATGGTC
TTGTTTTCCAGAAAATTCACAAAGTAATTGATCCCTACTCTTTTCTCTCTTCAGCTGTACCTTT
CGAATGTTTTCATTTGCTGTTTTGAGAACCGTATTACATTTACAGATTGCAAAAATTGCCAGTG
AAAAGTTCATTTGTTTATAATTAAGAAAGTGAAAGGACAGCTCTGTCAGTTGAAGCCATTTTAT
TGTTTGTCAGACTGAACAAAGCTTTCCTTTGGTGTCTGCTTCTGTATTCTAAACTGGAAGTAGA
CATCATATCCCAGCTAAACAGGGAAAGTTTTAGAACTTTGGGAATAGTTTGTCTATGCATGTAT
AATGCTGAGAAGGGTCTGCAGTGAAGAAGATAAGATAGACTTCTCCAGCACAACTATTACTCAT
TTGATAATTCAGTTTCATTTTTGCTCACATAATCTAAGTAAAGCCATATCAGAAACCAAGTTTT
TCTGTATGTTACACTAAATTTTAAGAACAAAGTCTATATTTAAAATAATCCAAACCCCAAATTT
GCTCATCCAAATTATGTCTTGGCCAGCAAGTTTTACATTAGAAGTTTTGAGACTTCCATTTATT
TGTGTCTTTTACAGAATTGTGTGACAATGACTTTTGGACATTTGTTCTTTCGGCTTTGGAATAT
TTACACAAGAATGGAGAAGGAACATCCAACTGGAGCATAATTGTCAAGGCAATAGAGAATTTAG
AGAAATAAAATAGCTGCATATCTCAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_000515	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA36440	(Get FASTA)	NCBI Sequence Viewer
	AAA66493	(Get FASTA)	NCBI Sequence Viewer
	AAD13945	(Get FASTA)	NCBI Sequence Viewer
	AAH69159	(Get FASTA)	NCBI Sequence Viewer
	AAI36264	(Get FASTA)	NCBI Sequence Viewer
	AAM21125	(Get FASTA)	NCBI Sequence Viewer
	BAA94488	(Get FASTA)	NCBI Sequence Viewer
	BAF84118	(Get FASTA)	NCBI Sequence Viewer
	CAA31908	(Get FASTA)	NCBI Sequence Viewer
	CAA40962	(Get FASTA)	NCBI Sequence Viewer
	CAA77560	(Get FASTA)	NCBI Sequence Viewer
	CAH03197	(Get FASTA)	NCBI Sequence Viewer
	EAW51377	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000316244
	ENSP00000316244.4
	ENSP00000423433.1
GenBank Protein	P08908	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_000515 ⟸ NM_000524

- UniProtKB:

Q6LAE7 (UniProtKB/Swiss-Prot), P08908 (UniProtKB/Swiss-Prot), A8K5W4 (UniProtKB/TrEMBL), Q5ZGX3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALE
RSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC
AIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKD
HGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNG
ESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPAS
FERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAI
INWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ

hide sequence

Ensembl Acc Id:

ENSP00000423433 ⟸ ENST00000506598

Ensembl Acc Id:

ENSP00000316244 ⟸ ENST00000323865

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P08908-F1-model_v2	AlphaFold	P08908	1-422	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:5286	AgrOrtholog
COSMIC	HTR1A	COSMIC
Ensembl Genes	ENSG00000178394	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000323865	ENTREZGENE
	ENST00000323865.5	UniProtKB/Swiss-Prot
	ENST00000506598.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000178394	GTEx
HGNC ID	HGNC:5286	ENTREZGENE
Human Proteome Map	HTR1A	Human Proteome Map
InterPro	5HT1A_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	5HT_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:3350	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	3350	ENTREZGENE
OMIM	109760	OMIM
PANTHER	ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	HTR1A	RGD, PharmGKB
PRINTS	5HT1ARECEPTR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	5HTRECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	5HT1A_HUMAN	UniProtKB/Swiss-Prot
	A8K5W4	ENTREZGENE, UniProtKB/TrEMBL
	D6RA34_HUMAN	UniProtKB/TrEMBL
	P08908	ENTREZGENE
	Q5ZGX3	ENTREZGENE, UniProtKB/TrEMBL
	Q6LAE7	ENTREZGENE
UniProt Secondary	Q6LAE7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-10	HTR1A	5-hydroxytryptamine receptor 1A		5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	Symbol and/or name change	5135510	APPROVED
2012-06-19	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	Symbol and/or name change	5135510	APPROVED
2012-02-14	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Human Phenotype Annotations - HPO

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Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Human Phenotype Annotations - HPO