APOA4 (apolipoprotein A4) - Rat Genome Database
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Gene: APOA4 (apolipoprotein A4) Homo sapiens
Analyze
Symbol: APOA4
Name: apolipoprotein A4
RGD ID: 737553
HGNC Page HGNC
Description: Exhibits several functions, including cation binding activity; cholesterol transfer activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in several processes, including lipid transport; positive regulation of lipid metabolic process; and protein-lipid complex subunit organization. Localizes to chylomicron; high-density lipoprotein particle; and very-low-density lipoprotein particle. Colocalizes with cell surface. Implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Biomarker of several diseases, including Huntington's disease; Leber hereditary optic neuropathy; autoimmune disease (multiple); eye disease (multiple); and intermediate coronary syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apo-AIV; apoA-IV; apolipoprotein A-IV; MGC142154; MGC142156
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11116,820,700 - 116,823,304 (-)EnsemblGRCh38hg38GRCh38
GRCh3811116,820,700 - 116,823,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711116,691,418 - 116,694,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,196,628 - 116,199,221 (-)NCBINCBI36hg18NCBI36
Build 3411116,196,628 - 116,199,162NCBI
Celera11113,849,234 - 113,851,827 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,623,690 - 112,626,283 (-)NCBIHuRef
CHM1_111116,576,178 - 116,578,767 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropropane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-nitro-p-phenylenediamine  (ISO)
2-nitropropane  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (EXP)
choline  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
doramapimod  (ISO)
fenofibrate  (ISO)
flavonoids  (ISO)
fluconazole  (ISO)
folic acid  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
high-density lipoprotein cholesterol  (EXP)
hydrazine  (ISO)
hydrogen peroxide  (EXP)
imipramine  (ISO)
isoniazide  (ISO)
ketoconazole  (ISO)
L-ethionine  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
metacetamol  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nefazodone  (ISO)
nickel atom  (EXP,ISO)
O-methyleugenol  (EXP)
ochratoxin A  (ISO)
octadecanoic acid  (EXP)
olanzapine  (EXP)
oleic acid  (EXP)
omeprazole  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rifaximin  (EXP)
rotenone  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulfasalazine  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
tebuconazole  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
triolein  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular protein metabolic process  (TAS)
cholesterol biosynthetic process  (IBA)
cholesterol efflux  (IBA,IDA)
cholesterol homeostasis  (IBA,IDA)
cholesterol metabolic process  (IDA)
chylomicron assembly  (TAS)
chylomicron remodeling  (IC,TAS)
high-density lipoprotein particle assembly  (IBA)
high-density lipoprotein particle remodeling  (IC)
hydrogen peroxide catabolic process  (IDA)
innate immune response in mucosa  (IDA)
intermembrane lipid transfer  (IEA)
leukocyte cell-cell adhesion  (IDA)
lipid catabolic process  (IDA)
lipid homeostasis  (IDA)
lipid transport  (IDA)
lipoprotein metabolic process  (IBA)
negative regulation of plasma lipoprotein oxidation  (IDA)
peripheral nervous system axon regeneration  (ISO)
phosphatidylcholine metabolic process  (IBA,IDA)
phospholipid efflux  (IBA,IDA)
positive regulation of cholesterol esterification  (IBA,IDA)
positive regulation of fatty acid biosynthetic process  (IBA,IDA)
positive regulation of lipid biosynthetic process  (IBA)
positive regulation of lipoprotein lipase activity  (IBA,IDA)
positive regulation of triglyceride catabolic process  (IBA,IDA)
protein-lipid complex assembly  (IMP)
regulation of cholesterol transport  (IDA)
regulation of intestinal cholesterol absorption  (IBA)
removal of superoxide radicals  (IDA)
response to lipid hydroperoxide  (IDA)
response to stilbenoid  (IEA)
response to triglyceride  (ISO)
retinoid metabolic process  (TAS)
reverse cholesterol transport  (IBA,IDA)
triglyceride homeostasis  (IBA)
very-low-density lipoprotein particle remodeling  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
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2. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Bouhenni RA, etal., Exp Eye Res. 2011 Jan;92(1):67-75. Epub 2010 Nov 13.
4. Boyles JK, etal., J Biol Chem. 1990 Oct 15;265(29):17805-15.
5. Broedl UC, etal., Inflamm Bowel Dis. 2007 Apr;13(4):391-7.
6. Carboni L, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1037-48. Epub 2010 May 23.
7. Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
8. Csaszar A, etal., Neurosci Lett. 1997 Jul 25;230(3):151-4.
9. Cui Y, etal., Am J Pathol. 2011 Mar;178(3):1298-308.
10. D'Aguanno S, etal., J Neuroimmunol. 2008 Jan;193(1-2):156-60. Epub 2007 Dec 3.
11. Domanski D, etal., J Proteomics. 2011 Nov 26.
12. Ebrini I, etal., Electrophoresis. 2000 Jun;21(11):2170-9.
13. GOA_HUMAN data from the GO Consortium
14. Huang YC, etal., PLoS One. 2011 Jan 31;6(1):e15809.
15. Ito Y, etal., Science. 1990 Aug 17;249(4970):790-3.
16. Ji Y, etal., Dement Geriatr Cogn Disord. 1999 Nov-Dec;10(6):473-5.
17. Jiang L, etal., Amino Acids. 2003 Jul;25(1):49-57.
18. Kee F, etal., Atherosclerosis. 1999 Jul;145(1):187-95.
19. Langner CA, etal., J Biol Chem. 1991 Jun 25;266(18):11955-64.
20. Li TW, etal., Chin Med J (Engl). 2010 Mar 5;123(5):537-43.
21. Liu XD, etal., Proteomics. 2006 Feb;6(3):1019-28.
22. Luczak M, etal., Proteome Sci. 2011 May 13;9:25.
23. Makino Y, etal., J Allergy Clin Immunol. 2010 Dec;126(6):1163-9.e5.
24. McGuirk J, etal., J Hematol Oncol. 2009 Apr 20;2:17.
25. Papassotiropoulos A, etal., J Clin Psychiatry. 2005 Jul;66(7):940-7.
26. Quilliot D, etal., Metabolism. 2001 Sep;50(9):1019-24.
27. Rewers M, etal., Diabetes. 1994 Dec;43(12):1485-9.
28. RGD automated import pipeline for gene-chemical interactions
29. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
30. Schonfeld G, etal., Metabolism. 1979 Oct;28(10):1001-10.
31. Shitama T, etal., Proteomics Clin Appl. 2008 Sep;2(9):1265-1280.
32. Tumani H, etal., J Neuroimmunol. 2009 Sep 29;214(1-2):109-12. Epub 2009 Jul 9.
33. Tumani H, etal., Neurosci Lett. 2009 Mar 13;452(2):214-7. Epub 2009 Jan 29.
34. Vowinkel T, etal., J Clin Invest. 2004 Jul;114(2):260-9.
35. Wong WM, etal., Circ Res. 2003 May 16;92(9):969-75. Epub 2003 Apr 3.
36. Yang YR, etal., Cell Mol Neurobiol. 2008 Aug;28(5):737-44. Epub 2008 Mar 15.
37. Zervos EE, etal., J Surg Res. 2006 Oct;135(2):317-22. Epub 2006 Jun 30.
Additional References at PubMed
PMID:1349197   PMID:1487136   PMID:1677358   PMID:1737067   PMID:1935934   PMID:1973689   PMID:2065039   PMID:2216752   PMID:2307668   PMID:2331673   PMID:2351649   PMID:2930771  
PMID:3036793   PMID:3080432   PMID:3095477   PMID:3095836   PMID:3611972   PMID:3755616   PMID:3931073   PMID:4345202   PMID:6706947   PMID:7728150   PMID:8688083   PMID:8956036  
PMID:9988739   PMID:10069372   PMID:10391210   PMID:11108737   PMID:11162594   PMID:11181750   PMID:11254757   PMID:11472750   PMID:11583715   PMID:11592042   PMID:11841825   PMID:11940599  
PMID:11941585   PMID:11952809   PMID:12082592   PMID:12116231   PMID:12121350   PMID:12220435   PMID:12417525   PMID:12477932   PMID:12495081   PMID:12556235   PMID:12664082   PMID:12691171  
PMID:12692552   PMID:12697303   PMID:12777472   PMID:12860258   PMID:12962772   PMID:14718574   PMID:14751811   PMID:15108119   PMID:15174051   PMID:15175360   PMID:15252864   PMID:15258202  
PMID:15304365   PMID:15311933   PMID:15359534   PMID:15488874   PMID:15489334   PMID:15559160   PMID:15649902   PMID:15721024   PMID:15764642   PMID:15806598   PMID:15823278   PMID:15864114  
PMID:15868628   PMID:15910632   PMID:15928313   PMID:15962178   PMID:16030523   PMID:16105043   PMID:16120654   PMID:16159879   PMID:16321685   PMID:16326171   PMID:16338932   PMID:16602826  
PMID:16651467   PMID:16710093   PMID:16763159   PMID:16770585   PMID:16781717   PMID:16788210   PMID:16929032   PMID:16945374   PMID:17130180   PMID:17154273   PMID:17261136   PMID:17378725  
PMID:17457002   PMID:17654446   PMID:17712726   PMID:17825930   PMID:17855807   PMID:17964293   PMID:18029348   PMID:18193043   PMID:18193044   PMID:18430727   PMID:18513389   PMID:18636124  
PMID:18660489   PMID:18664021   PMID:18676680   PMID:18678879   PMID:18789138   PMID:18948973   PMID:18996102   PMID:19057464   PMID:19060906   PMID:19060911   PMID:19074352   PMID:19131662  
PMID:19166692   PMID:19170196   PMID:19263529   PMID:19336370   PMID:19336475   PMID:19336561   PMID:19403283   PMID:19433068   PMID:19592705   PMID:19625176   PMID:19689828   PMID:19692168  
PMID:19701693   PMID:19732897   PMID:19878569   PMID:19913121   PMID:19948975   PMID:20031551   PMID:20117098   PMID:20139978   PMID:20164363   PMID:20430392   PMID:20551380   PMID:20554794  
PMID:20602615   PMID:20609189   PMID:20628086   PMID:20674306   PMID:20686565   PMID:20714348   PMID:20864672   PMID:21127258   PMID:21324458   PMID:21378990   PMID:21407247   PMID:21712729  
PMID:21767760   PMID:21873635   PMID:21909109   PMID:22286219   PMID:22516433   PMID:22528093   PMID:22579246   PMID:22916037   PMID:23096082   PMID:23132909   PMID:23288849   PMID:23338533  
PMID:23376485   PMID:23505323   PMID:23533145   PMID:24211975   PMID:24311788   PMID:24386095   PMID:24425874   PMID:24598141   PMID:24606699   PMID:25463085   PMID:25733664   PMID:26186194  
PMID:26397108   PMID:26485402   PMID:26491253   PMID:26556724   PMID:27068509   PMID:27262366   PMID:27344311   PMID:27412012   PMID:27559042   PMID:27622441   PMID:27870653   PMID:28246167  
PMID:28514442   PMID:29025558   PMID:29317355   PMID:30097533   PMID:30190457   PMID:32296183   PMID:32814053  


Genomics

Candidate Gene Status
APOA4 is a candidate Gene for QTL BW298_H
Comparative Map Data
APOA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11116,820,700 - 116,823,304 (-)EnsemblGRCh38hg38GRCh38
GRCh3811116,820,700 - 116,823,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711116,691,418 - 116,694,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,196,628 - 116,199,221 (-)NCBINCBI36hg18NCBI36
Build 3411116,196,628 - 116,199,162NCBI
Celera11113,849,234 - 113,851,827 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,623,690 - 112,626,283 (-)NCBIHuRef
CHM1_111116,576,178 - 116,578,767 (-)NCBICHM1_1
Apoa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,152,142 - 46,154,756 (+)NCBIGRCm39mm39
GRCm38946,240,844 - 46,243,458 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,240,696 - 46,243,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,048,927 - 46,051,541 (+)NCBIGRCm37mm9NCBIm37
MGSCv36945,992,149 - 45,994,285 (+)NCBImm8
Celera943,529,774 - 43,532,388 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
Apoa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0850,536,983 - 50,539,371 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,537,009 - 50,539,376 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,163,055 - 49,165,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4849,233,142 - 49,233,431 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1849,245,005 - 49,245,297 (+)NCBI
Celera846,121,074 - 46,123,455 (+)NCBICelera
Cytogenetic Map8q22NCBI
RH 3.4 Map8473.3RGD
Apoa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,155,801 - 18,160,701 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,158,095 - 18,160,636 (-)NCBIChiLan1.0ChiLan1.0
APOA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111115,591,788 - 115,594,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,591,788 - 115,594,382 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011111,659,186 - 111,661,790 (-)NCBIMhudiblu_PPA_v0panPan3
APOA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl516,751,799 - 16,754,837 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1516,751,588 - 16,754,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Apoa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365422,098,683 - 2,101,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,201,508 - 44,204,206 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,201,587 - 44,204,072 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,273,837 - 49,276,322 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOA4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,186,627 - 108,190,508 (-)NCBI
ChlSab1.1 Ensembl1108,186,921 - 108,189,698 (-)Ensembl
Apoa4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478412,237,329 - 12,240,013 (-)NCBI

Position Markers
G44371  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,691,636 - 116,691,734UniSTSGRCh37
Build 3611116,196,846 - 116,196,944RGDNCBI36
Celera11113,849,452 - 113,849,550RGD
Cytogenetic Map11q23UniSTS
HuRef11112,623,908 - 112,624,006UniSTS
GDB:185195  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,691,586 - 116,692,597UniSTSGRCh37
Build 3611116,196,796 - 116,197,807RGDNCBI36
Celera11113,849,402 - 113,850,413RGD
Cytogenetic Map11q23UniSTS
HuRef11112,623,858 - 112,624,869UniSTS
GDB:187004  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,693,439 - 116,694,131UniSTSGRCh37
Build 3611116,198,649 - 116,199,341RGDNCBI36
Celera11113,851,255 - 113,851,947RGD
Cytogenetic Map11q23UniSTS
HuRef11112,625,711 - 112,626,403UniSTS
GDB:555472  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,693,353 - 116,693,523UniSTSGRCh37
Build 3611116,198,563 - 116,198,733RGDNCBI36
Celera11113,851,169 - 113,851,339RGD
Cytogenetic Map11q23UniSTS
HuRef11112,625,625 - 112,625,795UniSTS
ECD09091  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,693,333 - 116,693,970UniSTSGRCh37
Build 3611116,198,543 - 116,199,180RGDNCBI36
Celera11113,851,149 - 113,851,786RGD
Cytogenetic Map11q23UniSTS
HuRef11112,625,605 - 112,626,242UniSTS
ECD09182  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,691,656 - 116,692,291UniSTSGRCh37
Build 3611116,196,866 - 116,197,501RGDNCBI36
Celera11113,849,472 - 113,850,107RGD
Cytogenetic Map11q23UniSTS
HuRef11112,623,928 - 112,624,563UniSTS
ECD09878  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,693,978 - 116,694,595UniSTSGRCh37
Build 3611116,199,188 - 116,199,805RGDNCBI36
Celera11113,851,794 - 113,852,411RGD
Cytogenetic Map11q23UniSTS
HuRef11112,626,250 - 112,626,867UniSTS
ECD12438  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,692,613 - 116,693,156UniSTSGRCh37
Build 3611116,197,823 - 116,198,366RGDNCBI36
Celera11113,850,429 - 113,850,972RGD
Cytogenetic Map11q23UniSTS
HuRef11112,624,885 - 112,625,428UniSTS
ECD20167  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,691,239 - 116,691,533UniSTSGRCh37
Build 3611116,196,449 - 116,196,743RGDNCBI36
Celera11113,849,055 - 113,849,349RGD
Cytogenetic Map11q23UniSTS
HuRef11112,623,511 - 112,623,805UniSTS
REN72989  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,694,658 - 116,694,892UniSTSGRCh37
Build 3611116,199,868 - 116,200,102RGDNCBI36
Celera11113,852,474 - 113,852,708RGD
Cytogenetic Map11q23UniSTS
HuRef11112,626,930 - 112,627,164UniSTS
REN72990  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,694,390 - 116,694,637UniSTSGRCh37
Build 3611116,199,600 - 116,199,847RGDNCBI36
Celera11113,852,206 - 113,852,453RGD
Cytogenetic Map11q23UniSTS
HuRef11112,626,662 - 112,626,909UniSTS
REN72991  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,694,156 - 116,694,409UniSTSGRCh37
Build 3611116,199,366 - 116,199,619RGDNCBI36
Celera11113,851,972 - 113,852,225RGD
Cytogenetic Map11q23UniSTS
HuRef11112,626,428 - 112,626,681UniSTS
REN72992  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,693,944 - 116,694,174UniSTSGRCh37
Build 3611116,199,154 - 116,199,384RGDNCBI36
Celera11113,851,760 - 113,851,990RGD
Cytogenetic Map11q23UniSTS
HuRef11112,626,216 - 112,626,446UniSTS
REN72993  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,693,695 - 116,693,922UniSTSGRCh37
Build 3611116,198,905 - 116,199,132RGDNCBI36
Celera11113,851,511 - 113,851,738RGD
Cytogenetic Map11q23UniSTS
HuRef11112,625,967 - 112,626,194UniSTS
REN72994  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,693,433 - 116,693,675UniSTSGRCh37
Build 3611116,198,643 - 116,198,885RGDNCBI36
Celera11113,851,249 - 113,851,491RGD
Cytogenetic Map11q23UniSTS
HuRef11112,625,705 - 112,625,947UniSTS
REN72995  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,693,219 - 116,693,452UniSTSGRCh37
Build 3611116,198,429 - 116,198,662RGDNCBI36
Celera11113,851,035 - 113,851,268RGD
Cytogenetic Map11q23UniSTS
HuRef11112,625,491 - 112,625,724UniSTS
REN72996  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,692,970 - 116,693,197UniSTSGRCh37
Build 3611116,198,180 - 116,198,407RGDNCBI36
Celera11113,850,786 - 113,851,013RGD
Cytogenetic Map11q23UniSTS
HuRef11112,625,242 - 112,625,469UniSTS
REN72997  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,692,703 - 116,692,968UniSTSGRCh37
Build 3611116,197,913 - 116,198,178RGDNCBI36
Celera11113,850,519 - 113,850,784RGD
Cytogenetic Map11q23UniSTS
HuRef11112,624,975 - 112,625,240UniSTS
REN72998  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,692,466 - 116,692,718UniSTSGRCh37
Build 3611116,197,676 - 116,197,928RGDNCBI36
Celera11113,850,282 - 113,850,534RGD
Cytogenetic Map11q23UniSTS
HuRef11112,624,738 - 112,624,990UniSTS
REN72999  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,692,261 - 116,692,485UniSTSGRCh37
Build 3611116,197,471 - 116,197,695RGDNCBI36
Celera11113,850,077 - 113,850,301RGD
Cytogenetic Map11q23UniSTS
HuRef11112,624,533 - 112,624,757UniSTS
REN73000  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,692,032 - 116,692,268UniSTSGRCh37
Build 3611116,197,242 - 116,197,478RGDNCBI36
Celera11113,849,848 - 113,850,084RGD
Cytogenetic Map11q23UniSTS
HuRef11112,624,304 - 112,624,540UniSTS
REN73001  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,691,739 - 116,692,013UniSTSGRCh37
Build 3611116,196,949 - 116,197,223RGDNCBI36
Celera11113,849,555 - 113,849,829RGD
Cytogenetic Map11q23UniSTS
HuRef11112,624,011 - 112,624,285UniSTS
REN73002  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,691,510 - 116,691,758UniSTSGRCh37
Build 3611116,196,720 - 116,196,968RGDNCBI36
Celera11113,849,326 - 113,849,574RGD
Cytogenetic Map11q23UniSTS
HuRef11112,623,782 - 112,624,030UniSTS
REN73003  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,691,293 - 116,691,526UniSTSGRCh37
Build 3611116,196,503 - 116,196,736RGDNCBI36
Celera11113,849,109 - 113,849,342RGD
Cytogenetic Map11q23UniSTS
HuRef11112,623,565 - 112,623,798UniSTS
REN73004  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,691,069 - 116,691,312UniSTSGRCh37
Build 3611116,196,279 - 116,196,522RGDNCBI36
Celera11113,848,885 - 113,849,128RGD
Cytogenetic Map11q23UniSTS
HuRef11112,623,341 - 112,623,584UniSTS
stSG601802  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,691,297 - 116,692,662UniSTSGRCh37
Build 3611116,196,507 - 116,197,872RGDNCBI36
Celera11113,849,113 - 113,850,478RGD
HuRef11112,623,569 - 112,624,934UniSTS
stSG601803  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,692,643 - 116,693,794UniSTSGRCh37
Build 3611116,197,853 - 116,199,004RGDNCBI36
Celera11113,850,459 - 113,851,610RGD
HuRef11112,624,915 - 112,626,066UniSTS
stSG601804  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711116,693,761 - 116,694,762UniSTSGRCh37
Build 3611116,198,971 - 116,199,972RGDNCBI36
Celera11113,851,577 - 113,852,578RGD
HuRef11112,626,033 - 112,627,034UniSTS
WI-19503  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q23UniSTS
HuRef11112,626,377 - 112,626,590UniSTS
GeneMap99-GB4 RH Map11373.38UniSTS
Whitehead-RH Map11513.9UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:241
Count of miRNA genes:228
Interacting mature miRNAs:236
Transcripts:ENST00000357780
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High 83 17 17 74 17
Medium 75 5 247 245 61 245 10 5 4 1 1 6 6
Low 179 119 243 161 85 154 261 93 78 4 111 93 8 62 132
Below cutoff 1120 1499 731 98 452 27 1674 1048 1243 65 708 739 73 435 1188

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000357780   ⟹   ENSP00000350425
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11116,820,700 - 116,823,304 (-)Ensembl
RefSeq Acc Id: NM_000482   ⟹   NP_000473
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811116,820,700 - 116,823,304 (-)NCBI
GRCh3711116,691,418 - 116,694,011 (-)ENTREZGENE
Build 3611116,196,628 - 116,199,221 (-)NCBI Archive
HuRef11112,623,690 - 112,626,283 (-)ENTREZGENE
CHM1_111116,576,178 - 116,578,767 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000473   ⟸   NM_000482
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSP00000350425   ⟸   ENST00000357780

Promoters
RGD ID:7222215
Promoter ID:EPDNEW_H16853
Type:multiple initiation site
Name:APOA4_1
Description:apolipoprotein A4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811116,823,304 - 116,823,364EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000482.4(APOA4):c.1140G>T (p.Gln380His) single nucleotide variant APOLIPOPROTEIN A-IV POLYMORPHISM, APOA4*1/APOA4*2 [RCV000019494] Chr11:116820918 [GRCh38]
Chr11:116691634 [GRCh37]
Chr11:11q23.3
pathogenic|benign
APOLIPOPROTEIN A-IV RARE VARIANT, APOA4*0 insertion APOLIPOPROTEIN A-IV RARE VARIANT, APOA4*0 [RCV000019495] Chr11:11q23 pathogenic|other
NM_000482.3(APOA4):c.748G>A (p.Glu250Lys) single nucleotide variant APOLIPOPROTEIN A-IV RARE VARIANT, APOA4*3 [RCV000019496] Chr11:116821310 [GRCh38]
Chr11:116692026 [GRCh37]
Chr11:11q23.3
pathogenic|other
APOLIPOPROTEIN A-IV RARE VARIANT, APOA4*5 insertion APOLIPOPROTEIN A-IV RARE VARIANT, APOA4*5 [RCV000019497] Chr11:11q23 pathogenic|other
GRCh38/hg38 11q23.2-23.3(chr11:113444446-120648921)x3 copy number gain See cases [RCV000050627] Chr11:113444446..120648921 [GRCh38]
Chr11:113315168..120519630 [GRCh37]
Chr11:112820378..120024840 [NCBI36]
Chr11:11q23.2-23.3
pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
GRCh38/hg38 11q23.3(chr11:116436425-118046231)x3 copy number gain See cases [RCV000053640] Chr11:116436425..118046231 [GRCh38]
Chr11:116307142..117916946 [GRCh37]
Chr11:115812352..117422156 [NCBI36]
Chr11:11q23.3
pathogenic
GRCh38/hg38 11q23.2-25(chr11:112864326-131189315)x3 copy number gain See cases [RCV000137582] Chr11:112864326..131189315 [GRCh38]
Chr11:112832130..131059210 [GRCh37]
Chr11:112240259..130564420 [NCBI36]
Chr11:11q23.2-25
pathogenic
GRCh38/hg38 11q23.3(chr11:115647670-117581883)x3 copy number gain See cases [RCV000137585] Chr11:115647670..117581883 [GRCh38]
Chr11:115518388..117452598 [GRCh37]
Chr11:115023598..116957808 [NCBI36]
Chr11:11q23.3
uncertain significance
GRCh38/hg38 11q23.3-25(chr11:116806268-135075271)x3 copy number gain See cases [RCV000138307] Chr11:116806268..135075271 [GRCh38]
Chr11:116676984..134945165 [GRCh37]
Chr11:116182194..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3(chr11:116801587-116880319)x3 copy number gain See cases [RCV000140064] Chr11:116801587..116880319 [GRCh38]
Chr11:116672303..116751035 [GRCh37]
Chr11:116177513..116256245 [NCBI36]
Chr11:11q23.3
uncertain significance
GRCh37/hg19 11q23.3-25(chr11:116691675-134889485) copy number gain not provided [RCV000767667] Chr11:116691675..134889485 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3(chr11:115215434-120559928)x3 copy number gain See cases [RCV000240308] Chr11:115215434..120559928 [GRCh37]
Chr11:11q23.3
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain See cases [RCV000449449] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116684163-134938470)x3 copy number gain See cases [RCV000447848] Chr11:116684163..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain See cases [RCV000512291] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain not provided [RCV000683373] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3(chr11:116669751-120979377)x3 copy number gain not provided [RCV000683365] Chr11:116669751..120979377 [GRCh37]
Chr11:11q23.3
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_000482.4(APOA4):c.1057T>G (p.Ser353Ala) single nucleotide variant not provided [RCV000881516] Chr11:116821001 [GRCh38]
Chr11:116691717 [GRCh37]
Chr11:11q23.3
benign
NM_000482.4(APOA4):c.1005C>T (p.Asp335=) single nucleotide variant not provided [RCV000942179] Chr11:116821053 [GRCh38]
Chr11:116691769 [GRCh37]
Chr11:11q23.3
likely benign
NM_000482.4(APOA4):c.1008G>T (p.Val336=) single nucleotide variant not provided [RCV000971019] Chr11:116821050 [GRCh38]
Chr11:116691766 [GRCh37]
Chr11:11q23.3
benign
NM_000482.4(APOA4):c.846C>T (p.Thr282=) single nucleotide variant not provided [RCV000974530] Chr11:116821212 [GRCh38]
Chr11:116691928 [GRCh37]
Chr11:11q23.3
benign
NM_000482.4(APOA4):c.780C>T (p.Ala260=) single nucleotide variant not provided [RCV000974531] Chr11:116821278 [GRCh38]
Chr11:116691994 [GRCh37]
Chr11:11q23.3
benign
Single allele deletion Short stature [RCV001003892] Chr11:114433313..131230466 [GRCh37]
Chr11:11q23.2-25
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:602 AgrOrtholog
COSMIC APOA4 COSMIC
Ensembl Genes ENSG00000110244 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000350425 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000357780 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000110244 GTEx
HGNC ID HGNC:602 ENTREZGENE
Human Proteome Map APOA4 Human Proteome Map
InterPro ApoA_E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 337 ENTREZGENE
OMIM 107690 OMIM
Pfam Apolipoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB APOA4 RGD, PharmGKB
UniGene Hs.1247 ENTREZGENE
UniProt APOA4_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q13784_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8MSL6 UniProtKB/Swiss-Prot
  Q14CW8 UniProtKB/Swiss-Prot
  Q6Q787 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-03 APOA4  apolipoprotein A4    apolipoprotein A-IV  Symbol and/or name change 5135510 APPROVED