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Gene: ADRB2 (adrenoceptor beta 2) Homo sapiens
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Symbol: ADRB2
Name: adrenoceptor beta 2
Description: Exhibits several functions, including amyloid-beta binding activity; beta2-adrenergic receptor activity; and norepinephrine binding activity. Involved in several processes, including activation of adenylate cyclase activity; positive regulation of cellular metabolic process; and regulation of signal transduction. Localizes to integral component of plasma membrane and receptor complex. Implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Biomarker of cholangiocarcinoma; chronic obstructive pulmonary disease; cystic fibrosis; and psoriasis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADRB2R; ADRBR; adrenergic receptor, beta 2; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; B2AR; BAR; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; BETA2AR; catecholamine receptor
Orthologs:
Mus musculus (house mouse) : Adrb2 (adrenergic receptor, beta 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Adrb2 (adrenoceptor beta 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adrb2 (adrenoceptor beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ADRB2 (adrenoceptor beta 2)
Canis lupus familiaris (dog) : ADRB2 (adrenoceptor beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adrb2 (adrenoceptor beta 2)
Sus scrofa (pig) : ADRB2 (adrenoceptor beta 2)
Chlorocebus sabaeus (African green monkey) : ADRB2 (adrenoceptor beta 2)
Heterocephalus glaber (naked mole-rat) : Adrb2 (adrenoceptor beta 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl5148,825,245 - 148,828,687 (+)EnsemblGRCh38hg38GRCh38
GRCh385148,826,611 - 148,828,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375148,206,156 - 148,254,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,186,349 - 148,188,381 (+)NCBINCBI36hg18NCBI36
Build 345148,186,368 - 148,188,379NCBI
Celera5144,288,206 - 144,290,248 (+)NCBI
Cytogenetic Map5q32NCBI
HuRef5143,352,751 - 143,354,793 (+)NCBIHuRef
CHM1_15147,638,640 - 147,640,684 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
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RNA-SEQ Expression

Sequence

Nucleotide Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on ADRB2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733595
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.