ADRB2 (adrenoceptor beta 2) - Rat Genome Database

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Gene: ADRB2 (adrenoceptor beta 2) Homo sapiens
Symbol: ADRB2
Name: adrenoceptor beta 2
RGD ID: 733595
Description: Enables several functions, including amyloid-beta binding activity; beta2-adrenergic receptor activity; and norepinephrine binding activity. Involved in several processes, including activation of adenylate cyclase activity; positive regulation of macroautophagy; and regulation of signal transduction. Located in Golgi apparatus and plasma membrane. Is integral component of plasma membrane. Part of receptor complex. Implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Biomarker of cholangiocarcinoma; chronic obstructive pulmonary disease; cystic fibrosis; and psoriasis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADRB2R; ADRBR; adrenergic receptor, beta 2; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; B2AR; BAR; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; BETA2AR; catecholamine receptor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5148,826,611 - 148,828,623 (+)EnsemblGRCh38hg38GRCh38
GRCh385148,826,611 - 148,828,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375148,206,174 - 148,208,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,186,349 - 148,188,381 (+)NCBINCBI36hg18NCBI36
Build 345148,186,368 - 148,188,379NCBI
Celera5144,288,206 - 144,290,248 (+)NCBI
Cytogenetic Map5q32NCBI
HuRef5143,352,751 - 143,354,793 (+)NCBIHuRef
CHM1_15147,638,640 - 147,640,684 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IMP,ISO)
AIDS Dementia Complex  (EXP)
Angina Pectoris  (IMP)
autistic disorder  (EXP)
Breast Neoplasms  (IEA)
bronchiolitis  (IDA)
cardiomyopathy  (EXP)
cardiovascular system disease  (IEA)
cholangiocarcinoma  (IEP)
chronic obstructive pulmonary disease  (IAGP,IDA,IEP,IMP)
congestive heart failure  (IAGP,ISO)
Coronary Disease  (IAGP)
cystic fibrosis  (IAGP,IEP)
dermatitis  (IAGP)
dilated cardiomyopathy  (EXP,ISO)
disease of metabolism  (IAGP)
end stage renal disease  (IDA)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis 1  (IAGP)
familial hyperlipidemia  (EXP)
fatty liver disease  (IAGP)
Fibrosis  (EXP)
Graves' disease  (IAGP)
Hereditary Neoplastic Syndromes  (IAGP)
human immunodeficiency virus infectious disease  (EXP)
Hyperlipoproteinemia Type II  (IAGP)
hypertension  (IAGP,IEA,ISO)
Hypertriglyceridemia  (IEA)
hypokalemia  (EXP)
hypothyroidism  (ISO)
Insulin Resistance  (EXP,IAGP,ISO)
interstitial cystitis  (IAGP)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (IAGP)
Liver Injury  (ISO)
lung disease  (EXP)
Metabolic Syndrome  (IAGP,IEA)
myasthenia gravis  (IAGP)
myocardial infarction  (IAGP,ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (IAGP)
nervous system disease  (EXP)
Neurodevelopmental Disorders  (IAGP)
obesity  (EXP,IAGP,IEA,ISO)
open-angle glaucoma  (IAGP)
Paroxysmal Dyspnea  (IAGP)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
primary open angle glaucoma  (IAGP)
Prostatic Neoplasms  (EXP)
psoriasis  (IAGP,IEP)
pulmonary edema  (IAGP,ISO)
Reperfusion Injury  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Stomach Neoplasms  (EXP)
toxic shock syndrome  (IAGP,IDA)
Tremor  (EXP)
type 2 diabetes mellitus  (IAGP,IEA)
ulcerative colitis  (ISO)
urticaria  (IAGP)
Ventricular Dysfunction, Left  (EXP)
Vestibulocochlear Nerve Injuries  (ISO)
viral encephalitis  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(5-hydroxyindol-3-yl)acetic acid  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-octopamine  (EXP)
(S)-nicotine  (EXP)
(S)-timolol (anhydrous)  (EXP)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (EXP)
1-nitropyrene  (EXP)
15-acetyldeoxynivalenol  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-imidazole  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(tert-butylamino)-1-(2-chlorophenyl)ethanol  (EXP)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP,ISO)
acebutolol  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
albuterol  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alprenolol  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
aristolochic acid  (EXP)
arsenite(3-)  (EXP,ISO)
asbestos  (EXP)
atenolol  (EXP,ISO)
beclomethasone  (EXP)
befunolol  (EXP)
benazepril  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[k]fluoranthene  (ISO)
betaxolol  (EXP)
bexarotene  (EXP)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bosentan  (EXP)
budesonide  (ISO)
busulfan  (ISO)
butanal  (EXP)
cadmium dichloride  (EXP)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (ISO)
carteolol  (EXP)
carvedilol  (EXP,ISO)
CGP 12177  (EXP,ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
clenbuterol  (ISO)
clobenpropit  (EXP)
clofibrate  (ISO)
clorgyline  (EXP)
clothianidin  (EXP)
cobalt atom  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
crocidolite asbestos  (EXP)
crotonaldehyde  (EXP)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
dioxygen  (EXP,ISO)
dobutamine  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP)
doxazosin  (ISO)
doxorubicin  (ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenoterol  (EXP,ISO)
fipronil  (EXP)
folic acid  (ISO)
fonofos  (EXP)
formoterol fumarate  (EXP,ISO)
furan  (ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexane  (EXP)
histamine  (EXP,ISO)
ICI 118551  (EXP,ISO)
imipramine  (EXP)
Immepip  (EXP)
iodocyanopindolol  (EXP,ISO)
isoprenaline  (EXP,ISO)
ketotifen  (EXP)
L-methionine  (ISO)
labetalol  (EXP,ISO)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
metaproterenol  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
methylisothiazolinone  (EXP)
metoprolol  (EXP,ISO)
mifepristone  (ISO)
miquelianin  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nadolol  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
nitric oxide  (ISO)
octopamine  (EXP)
olodaterol  (EXP)
orciprenaline  (EXP)
orphenadrine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (EXP)
pentanal  (EXP)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
picrotoxin  (ISO)
pindolol  (EXP,ISO)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium chromate  (EXP)
practolol  (EXP)
progesterone  (ISO)
propafenone  (EXP)
propanal  (EXP)
propranolol  (EXP,ISO)
propranolol hydrochloride  (ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (EXP)
putrescine  (EXP)
rac-lactic acid  (EXP)
reserpine  (ISO)
Salmeterol xinafoate  (EXP,ISO)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
sodium atom  (ISO)
sodium dodecyl sulfate  (EXP)
sotalol  (EXP)
spermidine  (EXP)
spermine  (EXP)
streptozocin  (ISO)
sunitinib  (EXP)
synephrine  (ISO)
tamoxifen  (ISO)
terbufos  (EXP)
terbutaline  (EXP,ISO)
tetrachloroethene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichostatin A  (EXP)
triclosan  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vincristine  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (IDA)
activation of transmembrane receptor protein tyrosine kinase activity  (TAS)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (TAS)
adrenergic receptor signaling pathway  (IDA)
aging  (ISO)
associative learning  (ISO)
bone resorption  (IEA,ISO)
brown fat cell differentiation  (IEA,ISO)
cell surface receptor signaling pathway  (TAS)
cellular response to amyloid-beta  (IGI)
cellular response to hypoxia  (ISO)
desensitization of G protein-coupled receptor signaling pathway by arrestin  (IDA)
diaphragm contraction  (ISO)
diet induced thermogenesis  (IEA,ISO)
endosome to lysosome transport  (TAS)
estrous cycle  (ISO)
excitatory postsynaptic potential  (ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
heat generation  (IEA,ISO)
liver development  (ISO)
liver regeneration  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of multicellular organism growth  (IEA,ISO)
negative regulation of ossification  (ISO)
negative regulation of platelet aggregation  (ISO)
negative regulation of smooth muscle contraction  (IBA,ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of urine volume  (ISO)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IBA,ISO)
positive regulation of AMPA receptor activity  (IGI)
positive regulation of apoptotic process  (ISO)
positive regulation of ATPase activity  (ISO)
positive regulation of autophagosome maturation  (IDA)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cAMP-dependent protein kinase activity  (TAS)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (ISS)
positive regulation of heart contraction  (ISO)
positive regulation of lipophagy  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of mini excitatory postsynaptic potential  (IEA)
positive regulation of potassium ion transport  (ISO)
positive regulation of protein kinase A signaling  (IGI)
positive regulation of protein serine/threonine kinase activity  (IGI)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of sodium ion transport  (ISO)
positive regulation of the force of heart contraction by epinephrine  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
receptor-mediated endocytosis  (IDA)
regulation of calcium ion transport  (ISO)
regulation of sensory perception of pain  (ISO)
regulation of sodium ion transport  (IEA,ISO)
regulation of synaptic vesicle exocytosis  (ISO)
regulation of systemic arterial blood pressure by norepinephrine-epinephrine  (ISO)
regulation of vein smooth muscle contraction  (ISO)
response to catecholamine  (ISO)
response to cold  (IEA,ISO)
response to dexamethasone  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to monoamine  (ISO)
response to progesterone  (ISO)
response to psychosocial stress  (TAS)
response to testosterone  (ISO)
synaptic transmission, glutamatergic  (ISO)
vasodilation  (ISO)
wound healing  (ISO)


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Additional References at PubMed
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PMID:8386307   PMID:8557631   PMID:8662852   PMID:8672451   PMID:8892658   PMID:9228019   PMID:9235896   PMID:9399946   PMID:9507004   PMID:9560162   PMID:9671706   PMID:9819198  
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PMID:11214319   PMID:11229437   PMID:11230287   PMID:11238007   PMID:11246467   PMID:11246538   PMID:11258696   PMID:11278447   PMID:11278940   PMID:11288039   PMID:11306963   PMID:11309381  
PMID:11371409   PMID:11380082   PMID:11434877   PMID:11441182   PMID:11466580   PMID:11526121   PMID:11588219   PMID:11706779   PMID:11713122   PMID:11713125   PMID:11735081   PMID:11739457  
PMID:11775126   PMID:11775127   PMID:11778498   PMID:11785682   PMID:11798553   PMID:11798846   PMID:11809767   PMID:11809992   PMID:11821698   PMID:11821707   PMID:11836685   PMID:11854867  
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PMID:31142730   PMID:31264537   PMID:31285095   PMID:31290053   PMID:31356401   PMID:31364142   PMID:31395667   PMID:31425733   PMID:31481635   PMID:31604529   PMID:31619245   PMID:31620969  
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PMID:32229175   PMID:32530095   PMID:32624423   PMID:32814053   PMID:32828531   PMID:32918113   PMID:33181690   PMID:33257561   PMID:33356961   PMID:33451866   PMID:33526736   PMID:34090290  


Candidate Gene Status
ADRB2 is a candidate Gene for QTL BW456_H
ADRB2 is a candidate Gene for QTL BW455_H
Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5148,826,611 - 148,828,623 (+)EnsemblGRCh38hg38GRCh38
GRCh385148,826,611 - 148,828,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375148,206,174 - 148,208,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,186,349 - 148,188,381 (+)NCBINCBI36hg18NCBI36
Build 345148,186,368 - 148,188,379NCBI
Celera5144,288,206 - 144,290,248 (+)NCBI
Cytogenetic Map5q32NCBI
HuRef5143,352,751 - 143,354,793 (+)NCBIHuRef
CHM1_15147,638,640 - 147,640,684 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391862,310,784 - 62,313,052 (-)NCBIGRCm39mm39
GRCm39 Ensembl1862,310,887 - 62,313,030 (-)Ensembl
GRCm381862,177,713 - 62,179,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1862,177,816 - 62,179,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371862,337,470 - 62,339,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv361862,303,185 - 62,305,328 (-)NCBImm8
Celera1863,462,804 - 63,464,949 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1835.1NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21855,642,459 - 55,644,501 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1855,502,903 - 55,644,512 (-)Ensembl
Rnor_6.01857,513,792 - 57,515,834 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1857,513,793 - 57,515,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,739,990 - 56,742,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41858,174,958 - 58,177,000 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11858,247,190 - 58,249,232 (-)NCBI
Celera1853,789,848 - 53,791,890 (-)NCBICelera
RH 3.4 Map18542.9RGD
Cytogenetic Map18q12.1NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554155,515,697 - 5,516,980 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554155,515,157 - 5,517,198 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.15150,267,321 - 150,269,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,267,554 - 150,315,892 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05144,259,756 - 144,398,421 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1460,048,502 - 60,050,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,941,517 - 60,050,298 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,812,943 - 59,814,888 (-)NCBI
ROS_Cfam_1.0460,537,283 - 60,539,228 (-)NCBI
UMICH_Zoey_3.1460,317,278 - 60,319,223 (-)NCBI
UNSW_CanFamBas_1.0460,444,286 - 60,446,231 (-)NCBI
UU_Cfam_GSD_1.0460,962,485 - 60,964,430 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213144,411,444 - 144,414,154 (-)NCBI
SpeTri2.0NW_0049365045,985,407 - 5,987,453 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2150,032,782 - 150,035,591 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,032,649 - 150,035,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12351,445,920 - 51,447,942 (+)NCBI
ChlSab1.1 Ensembl2351,446,154 - 51,447,401 (+)Ensembl
Vero_WHO_p1.0NW_02366603426,307,284 - 26,309,305 (-)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247748,211,723 - 8,215,962 (+)NCBI

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,206,371 - 148,206,581UniSTSGRCh37
Build 365148,186,564 - 148,186,774RGDNCBI36
Celera5144,288,421 - 144,288,631RGD
Cytogenetic Map5q31-q32UniSTS
HuRef5143,352,966 - 143,353,176UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,207,675 - 148,207,961UniSTSGRCh37
Build 365148,187,868 - 148,188,154RGDNCBI36
Celera5144,289,726 - 144,290,012RGD
Cytogenetic Map5q31-q32UniSTS
HuRef5143,354,271 - 143,354,557UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,206,421 - 148,207,333UniSTSGRCh37
Build 365148,186,614 - 148,187,526RGDNCBI36
Celera5144,288,471 - 144,289,383RGD
Cytogenetic Map5q31-q32UniSTS
HuRef5143,353,016 - 143,353,928UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,206,454 - 148,206,873UniSTSGRCh37
Build 365148,186,647 - 148,187,066RGDNCBI36
Celera5144,288,504 - 144,288,923RGD
Cytogenetic Map5q31-q32UniSTS
HuRef5143,353,049 - 143,353,468UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,206,866 - 148,207,527UniSTSGRCh37
Build 365148,187,059 - 148,187,720RGDNCBI36
Celera5144,288,916 - 144,289,577RGD
Cytogenetic Map5q31-q32UniSTS
HuRef5143,353,461 - 143,354,122UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,206,811 - 148,207,265UniSTSGRCh37
Build 365148,187,004 - 148,187,458RGDNCBI36
Celera5144,288,861 - 144,289,315RGD
HuRef5143,353,406 - 143,353,860UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,207,045 - 148,207,443UniSTSGRCh37
Build 365148,187,238 - 148,187,636RGDNCBI36
Celera5144,289,095 - 144,289,493RGD
Cytogenetic Map5q31-q32UniSTS
HuRef5143,353,640 - 143,354,038UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,206,240 - 148,206,576UniSTSGRCh37
Build 365148,186,433 - 148,186,769RGDNCBI36
Celera5144,288,290 - 144,288,626RGD
Cytogenetic Map5q31-q32UniSTS
HuRef5143,352,835 - 143,353,171UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,207,612 - 148,208,281UniSTSGRCh37
Build 365148,187,805 - 148,188,474RGDNCBI36
Celera5144,289,662 - 144,290,332RGD
HuRef5143,354,207 - 143,354,877UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,207,839 - 148,208,101UniSTSGRCh37
Build 365148,188,032 - 148,188,294RGDNCBI36
Celera5144,289,890 - 144,290,152RGD
Cytogenetic Map5q31-q32UniSTS
HuRef5143,354,435 - 143,354,697UniSTS
GeneMap99-GB4 RH Map5571.96UniSTS
Whitehead-RH Map5486.1UniSTS
NCBI RH Map5891.6UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,206,521 - 148,207,408UniSTSGRCh37
GRCh375148,207,000 - 148,207,207UniSTSGRCh37
Celera5144,288,571 - 144,289,458UniSTS
Celera5144,289,050 - 144,289,257UniSTS
HuRef5143,353,595 - 143,353,802UniSTS
HuRef5143,353,116 - 143,354,003UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375148,206,521 - 148,207,408UniSTSGRCh37
GRCh375148,207,000 - 148,207,207UniSTSGRCh37
Celera5144,288,571 - 144,289,458UniSTS
Celera5144,289,050 - 144,289,257UniSTS
HuRef5143,353,595 - 143,353,802UniSTS
HuRef5143,353,116 - 143,354,003UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:275
Count of miRNA genes:221
Interacting mature miRNAs:254
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
Medium 99 109 85 105 222 81 1885 99 72 52 225 543 37 1 1063 700 3 2
Low 2238 2843 1338 504 1553 368 2407 2062 2989 293 997 975 138 141 2074 1
Below cutoff 77 39 298 12 133 13 60 28 663 73 230 64 14 1


Nucleotide Sequences
RefSeq Transcripts NG_016421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA886615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC011354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF022953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF022954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF022955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF022956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF169225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF202305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF203386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY136741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA440083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA705141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ094845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU332834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC295426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC633338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC633339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC633340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000305988   ⟹   ENSP00000305372
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5148,826,611 - 148,828,623 (+)Ensembl
RefSeq Acc Id: NM_000024   ⟹   NP_000015
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh385148,826,611 - 148,828,623 (+)NCBI
GRCh375148,206,156 - 148,254,628 (+)NCBI
Build 365148,186,349 - 148,188,381 (+)NCBI Archive
HuRef5143,352,751 - 143,354,793 (+)ENTREZGENE
CHM1_15147,638,640 - 147,640,684 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_000015   ⟸   NM_000024
- Sequence:
RefSeq Acc Id: ENSP00000305372   ⟸   ENST00000305988
Protein Domains

RGD ID:6802826
Promoter ID:HG_KWN:51472
SO ACC ID:SO:0000170
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Human AssemblyChrPosition (strand)Source
Build 365148,186,009 - 148,186,509 (+)MPROMDB
RGD ID:6850194
Promoter ID:EP25039
Type:multiple initiation site
Description:beta 2-Adrenergic receptor, ADRB2, ADRB2R or B2AR gene
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database,
Notes:homology_group=Homology group 159; Mammalian beta 2-adrenergic receptor
Experiment Methods:Nuclease protection; Primer extension with homologous sequence ladder
Regulation:various tissues; (induced by or strongly expressed in) hydrocortisone
Human AssemblyChrPosition (strand)Source
Build 365148,186,379 - 148,186,439EPD
RGD ID:6871190
Promoter ID:EPDNEW_H8760
Type:initiation region
Description:adrenoceptor beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh385148,826,623 - 148,826,683EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000024.5(ADRB2):c.46A>G (p.Arg16Gly) single nucleotide variant Asthma, nocturnal, susceptibility to [RCV000019316]|not provided [RCV000873016] Chr5:148826877 [GRCh38]
Chr5:148206440 [GRCh37]
risk factor|benign
NM_000024.5(ADRB2):c.79C>G (p.Gln27Glu) single nucleotide variant ADRB2 POLYMORPHISM [RCV000033191]|not provided [RCV000873015] Chr5:148826910 [GRCh38]
Chr5:148206473 [GRCh37]
risk factor|benign
NM_000024.5(ADRB2):c.491C>T (p.Thr164Ile) single nucleotide variant Beta-2-adrenoreceptor agonist, reduced response to [RCV000019320] Chr5:148827322 [GRCh38]
Chr5:148206885 [GRCh37]
drug response
ADRB2, -47C-T single nucleotide variant Beta-2-adrenoreceptor agonist, reduced response to [RCV000019321] Chr5:5q32-q34 pathogenic|drug response
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
NM_000024.5(ADRB2):c.46= (p.Arg16=) single nucleotide variant salbutamol response - Efficacy [RCV000211205]|salmeterol response - Efficacy [RCV000211334] Chr5:148826877 [GRCh38]
Chr5:148206440 [GRCh37]
drug response
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
GRCh38/hg38 5q31.3-32(chr5:141089988-149530678)x3 copy number gain See cases [RCV000139504] Chr5:141089988..149530678 [GRCh38]
Chr5:140469572..148910241 [GRCh37]
Chr5:140449756..148890434 [NCBI36]
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
likely benign
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV001381154]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
GRCh37/hg19 5q31.3-32(chr5:141113273-149154835)x1 copy number loss See cases [RCV000510497] Chr5:141113273..149154835 [GRCh37]
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
NM_000024.6(ADRB2):c.*34del deletion not provided [RCV001534572] Chr5:148828097 [GRCh38]
Chr5:148207660 [GRCh37]
NM_000024.5(ADRB2):c.771A>T (p.Gly257=) single nucleotide variant not provided [RCV000966605] Chr5:148827602 [GRCh38]
Chr5:148207165 [GRCh37]
likely benign
NM_000024.5(ADRB2):c.990A>C (p.Pro330=) single nucleotide variant not provided [RCV000966817] Chr5:148827821 [GRCh38]
Chr5:148207384 [GRCh37]
likely benign
NM_000024.5(ADRB2):c.560A>G (p.Asn187Ser) single nucleotide variant not provided [RCV000873923] Chr5:148827391 [GRCh38]
Chr5:148206954 [GRCh37]
likely benign
NM_000024.5(ADRB2):c.1179T>C (p.Thr393=) single nucleotide variant not provided [RCV000874253] Chr5:148828010 [GRCh38]
Chr5:148207573 [GRCh37]
NM_000024.5(ADRB2):c.66C>T (p.His22=) single nucleotide variant not provided [RCV000873645] Chr5:148826897 [GRCh38]
Chr5:148206460 [GRCh37]
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
uncertain significance
NM_000024.5(ADRB2):c.659C>G (p.Ser220Cys) single nucleotide variant not provided [RCV000873803] Chr5:148827490 [GRCh38]
Chr5:148207053 [GRCh37]
GRCh37/hg19 5q31.3-32(chr5:140424333-148985999)x3 copy number gain not provided [RCV000848228] Chr5:140424333..148985999 [GRCh37]
uncertain significance
NM_000024.5(ADRB2):c.206A>G (p.Asn69Ser) single nucleotide variant not provided [RCV000876878] Chr5:148827037 [GRCh38]
Chr5:148206600 [GRCh37]
NM_000024.5(ADRB2):c.276C>G (p.Ala92=) single nucleotide variant not provided [RCV000923156] Chr5:148827107 [GRCh38]
Chr5:148206670 [GRCh37]
likely benign
NM_000024.5(ADRB2):c.1098T>C (p.Tyr366=) single nucleotide variant not provided [RCV000874830] Chr5:148827929 [GRCh38]
Chr5:148207492 [GRCh37]
NM_000024.5(ADRB2):c.492C>A (p.Thr164=) single nucleotide variant not provided [RCV000935134] Chr5:148827323 [GRCh38]
Chr5:148206886 [GRCh37]
likely benign
Single allele single nucleotide variant not provided [RCV001537123] Chr5:148826178 [GRCh38]
Chr5:148205741 [GRCh37]
NM_000024.6(ADRB2):c.*25_*26insG insertion not provided [RCV001541383] Chr5:148828098..148828099 [GRCh38]
Chr5:148207661..148207662 [GRCh37]

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:286 AgrOrtholog
Ensembl Genes ENSG00000169252 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000305372 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000305988 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000169252 GTEx
Human Proteome Map ADRB2 Human Proteome Map
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRB2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:154 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
OMIM 109690 OMIM
  600807 OMIM
  601665 OMIM
PANTHER PTHR24248:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRENRGCB2AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary B0LPE4 UniProtKB/Swiss-Prot
  B2R7X2 UniProtKB/Swiss-Prot
  O14823 UniProtKB/Swiss-Prot
  O14824 UniProtKB/Swiss-Prot
  O14825 UniProtKB/Swiss-Prot
  O14826 UniProtKB/Swiss-Prot
  Q4JG18 UniProtKB/Swiss-Prot
  Q53GA6 UniProtKB/Swiss-Prot
  Q6GMT4 UniProtKB/Swiss-Prot
  Q6P4D8 UniProtKB/Swiss-Prot
  Q8NEQ9 UniProtKB/Swiss-Prot
  Q96EC3 UniProtKB/Swiss-Prot
  Q9UCZ0 UniProtKB/Swiss-Prot
  Q9UCZ1 UniProtKB/Swiss-Prot
  Q9UCZ2 UniProtKB/Swiss-Prot
  Q9UCZ3 UniProtKB/Swiss-Prot
  Q9UH95 UniProtKB/Swiss-Prot
  Q9UHA1 UniProtKB/Swiss-Prot
  Q9UMZ5 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 ADRB2  adrenoceptor beta 2  ADRB2  adrenoceptor beta 2, surface  Symbol and/or name change 5135510 APPROVED
2015-12-01 ADRB2  adrenoceptor beta 2    adrenoceptor beta 2, surface  Symbol and/or name change 5135510 APPROVED
2012-05-15 ADRB2  adrenoceptor beta 2, surface  ADRB2  adrenergic, beta-2-, receptor, surface  Symbol and/or name change 5135510 APPROVED
2011-08-16 ADRB2  adrenergic, beta-2-, receptor, surface  ADRB2  adrenergic, beta-2-, receptor, surface  Symbol and/or name change 5135510 APPROVED