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Gene: NTRK2 (neurotrophic receptor tyrosine kinase 2) Homo sapiens
Symbol: NTRK2
Name: neurotrophic receptor tyrosine kinase 2
Description: Exhibits brain-derived neurotrophic factor-activated receptor activity and neurotrophin binding activity. Involved in brain-derived neurotrophic factor receptor signaling pathway. Localizes to the integral component of plasma membrane and receptor complex. Implicated in Alzheimer's disease; autistic disorder; early infantile epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Biomarker of bipolar disorder; idiopathic pulmonary fibrosis; major depressive disorder; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; EIEE58; GP145-TrkB; neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; OBHD; trk-B; TRKB; trkB tyrosine kinase; tropomyosin-related kinase B; tyrosine kinase receptor B
Mus musculus (house mouse) : Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Canis lupus familiaris (dog) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)
Sus scrofa (pig) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Chlorocebus sabaeus (green monkey) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Heterocephalus glaber (naked mole-rat) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl984,668,551 - 85,027,070 (+)Ensembl
GRCh38984,668,458 - 85,027,070 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37987,283,417 - 87,641,985 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36986,473,286 - 86,828,325 (+)NCBINCBI36hg18NCBI36
Build 34984,514,246 - 84,866,963NCBI
Celera957,854,390 - 58,209,019 (+)NCBI
Cytogenetic Map9q21.33NCBI
HuRef957,108,647 - 57,463,914 (+)NCBIHuRef
CHM1_1987,429,880 - 87,788,555 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NTRK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731305
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.