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ONTOLOGY REPORT - ANNOTATIONS


Term:clomipramine
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Accession:CHEBI:47780 term browser browse the term
Definition:A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Synonyms:exact_synonym: 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
 related_synonym: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE;   3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine;   3-chloroimipramine;   Formula=C19H23ClN2;   G 34586;   InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;   InChIKey=GDLIGKIOYRNHDA-UHFFFAOYSA-N;   SMILES=CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12;   chlorimipramine;   monochlorimipramine
 alt_id: CHEBI:3754;   CHEBI:47359
 xref: Beilstein:1323477 "ChemIDplus";   CAS:303-49-1 "ChemIDplus";   CAS:303-49-1 "KEGG COMPOUND";   CAS:303-49-1 "NIST Chemistry WebBook";   DrugBank:DB01242;   Drug_Central:701 "DrugCentral";   KEGG:C06918;   KEGG:D07727;   LINCS:LSM-3171
 xref_mesh: MESH:D002997
 xref: PDBeChem:CXX;   PMID:12007764 "Europe PMC";   PMID:12084414 "Europe PMC";   PMID:16085036 "Europe PMC";   PMID:17471183 "Europe PMC";   PMID:19747949 "Europe PMC";   PMID:19810911 "Europe PMC";   Patent:CH371799;   Patent:US3467650;   Reaxys:1323477 "Reaxys";   Wikipedia:Clomipramine
 cyclic_relationship: is_conjugate_base_of CHEBI:64209


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clomipramine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aadat aminoadipate aminotransferase JBrowse link 16 32,832,001 32,868,680 RGD:6480464
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:6480464
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 JBrowse link 1 240,584,233 240,601,843 RGD:6480464
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 JBrowse link 12 22,665,128 22,676,079 RGD:6480464
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:6480464
G Asns asparagine synthetase (glutamine-hydrolyzing) JBrowse link 4 33,742,876 33,761,106 RGD:6480464
G Bhmt betaine-homocysteine S-methyltransferase JBrowse link 2 23,236,573 23,256,158 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cdkn2c cyclin-dependent kinase inhibitor 2C JBrowse link 5 129,347,731 129,352,886 RGD:6480464
G Ces2h carboxylesterase 2H JBrowse link 19 37,052,555 37,067,176 RGD:6480464
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 JBrowse link 8 122,789,208 122,807,560 RGD:6480464
G Cpped1 calcineurin-like phosphoesterase domain containing 1 JBrowse link 10 3,655,038 3,774,887 RGD:6480464
G Crem cAMP responsive element modulator JBrowse link 17 57,021,704 57,090,888 RGD:6480464
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 JBrowse link 1 83,711,223 83,725,222 RGD:6480464
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 JBrowse link 1 251,325,923 251,338,404 RGD:6480464
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6480464
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 JBrowse link 7 15,179,472 15,191,113 RGD:6480464
G Dcaf8 DDB1 and CUL4 associated factor 8 JBrowse link 13 90,532,153 90,587,542 RGD:6480464
G Depp1 DEPP1, autophagy regulator JBrowse link 4 148,780,330 148,784,566 RGD:6480464
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:6480464
G Eif4b eukaryotic translation initiation factor 4B JBrowse link 7 143,679,656 143,701,452 RGD:6480464
G Ephx1 epoxide hydrolase 1 JBrowse link 13 99,271,390 99,300,580 RGD:6480464
G Erp29 endoplasmic reticulum protein 29 JBrowse link 12 40,619,377 40,625,884 RGD:6480464
G Fabp1 fatty acid binding protein 1 JBrowse link 4 99,063,181 99,066,957 RGD:6480464
G Gckr glucokinase regulator JBrowse link 6 26,355,296 26,385,761 RGD:6480464
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 JBrowse link 1 198,199,032 198,209,178 RGD:6480464
G Gls2 glutaminase 2 JBrowse link 7 2,605,679 2,621,853 RGD:6480464
G Got2 glutamic-oxaloacetic transaminase 2 JBrowse link 19 9,587,637 9,613,323 RGD:6480464
G Grb14 growth factor receptor bound protein 14 JBrowse link 3 50,937,403 51,054,447 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Hal histidine ammonia lyase JBrowse link 7 34,326,087 34,356,413 RGD:6480464
G Hmgb2 high mobility group box 2 JBrowse link 16 36,077,615 36,080,191 RGD:6480464
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 JBrowse link 2 52,427,351 52,445,082 RGD:6480464
G Hpn hepsin JBrowse link 1 89,534,112 89,549,575 RGD:6480464
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il33 interleukin 33 JBrowse link 1 248,112,611 248,147,030 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Inhbe inhibin subunit beta E JBrowse link 7 70,641,423 70,642,848 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Lox lysyl oxidase JBrowse link 18 47,500,320 47,577,819 RGD:6480464
G Lss lanosterol synthase JBrowse link 20 12,844,522 12,870,474 RGD:6480464
G Manba mannosidase beta JBrowse link 2 240,668,213 240,760,264 RGD:6480464
G Mlx MAX dimerization protein MLX JBrowse link 10 88,997,011 89,002,154 RGD:6480464
G Mrps18b mitochondrial ribosomal protein S18B JBrowse link 20 3,344,870 3,350,929 RGD:6480464
G Msmo1 methylsterol monooxygenase 1 JBrowse link 16 26,859,441 26,875,880 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 5 151,776,004 151,779,319 RGD:6480464
G Nrep neuronal regeneration related protein JBrowse link 18 26,183,753 26,212,796 RGD:6480464
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:6480464
G Nupr1 nuclear protein 1, transcriptional regulator JBrowse link 1 194,767,484 194,769,519 RGD:6480464
G Oaf out at first homolog JBrowse link 8 47,511,718 47,529,689 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pc pyruvate carboxylase JBrowse link 1 219,759,157 219,859,854 RGD:6480464
G Pecr peroxisomal trans-2-enoyl-CoA reductase JBrowse link 9 79,601,937 79,630,547 RGD:6480464
G Phyh phytanoyl-CoA 2-hydroxylase JBrowse link 17 77,287,580 77,304,482 RGD:6480464
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link 18 24,918,402 24,928,822 RGD:6480464
G Rbl2 RB transcriptional corepressor like 2 JBrowse link 19 17,300,088 17,346,865 RGD:6480464
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:6480464
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6480464
G Serpina3m serine (or cysteine) proteinase inhibitor, clade A, member 3M JBrowse link 6 127,808,785 127,816,067 RGD:6480464
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 JBrowse link 1 144,069,641 144,200,402 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc2a3 solute carrier family 2 member 3 JBrowse link 4 155,549,991 155,626,018 RGD:6480464
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:6480464
G Slc6a6 solute carrier family 6 member 6 JBrowse link 4 123,638,619 123,713,469 RGD:6480464
G Slco1a4 solute carrier organic anion transporter family, member 1a4 JBrowse link 4 175,969,549 176,026,227 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:6480464
G St13 ST13, Hsp70 interacting protein JBrowse link 7 122,585,770 122,635,731 RGD:6480464
G Stbd1 starch binding domain 1 JBrowse link 14 16,976,355 16,979,760 RGD:6480464
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:6480464
G Tac1 tachykinin, precursor 1 JBrowse link 4 33,638,853 33,646,819 RGD:6480464
G Tagln transgelin JBrowse link 8 50,222,895 50,228,369 RGD:6480464
G Tex261 testis expressed 261 JBrowse link 4 115,446,830 115,454,035 RGD:6480464
G Thra thyroid hormone receptor alpha JBrowse link 10 86,657,285 86,684,935 RGD:6480464
G Timm10b translocase of inner mitochondrial membrane 10B JBrowse link 1 170,471,265 170,474,111 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 JBrowse link 16 20,668,925 20,671,127 RGD:6480464
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6480464
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 JBrowse link 14 22,192,970 22,217,094 RGD:6480464
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 JBrowse link 14 22,724,399 22,736,148 RGD:6480464
G Wipi1 WD repeat domain, phosphoinositide interacting 1 JBrowse link 10 97,859,730 97,896,949 RGD:6480464

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  CHEBI ontology 19657
    role 19601
      biological role 19599
        pharmacological role 18680
          neurotransmitter agent 16228
            serotonergic drug 3850
              clomipramine 89
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  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic molecule 19332
                              organic cyclic compound 19083
                                organic heterocyclic compound 18154
                                  organic heteropolycyclic compound 17419
                                    organic heterotricyclic compound 13729
                                      mancude organic heterotricyclic parent 344
                                        5H-dibenzo[b,f]azepine 122
                                          imipramine 122
                                            clomipramine 89
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.