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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(-)-epicatechin
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Accession:CHEBI:90 term browser browse the term
Definition:A catechin with (2R,3R)-configuration.
Synonyms:exact_synonym: (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
 related_synonym: Formula=C15H14O6;   InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1;   InChIKey=PFTAWBLQPZVEMU-UKRRQHHQSA-N;   SMILES=[H][C@@]1(Oc2cc(O)cc(O)c2C[C@H]1O)c1ccc(O)c(O)c1
 alt_id: CHEBI:18484
 xref: CAS:490-46-0;   KEGG:C09727;   KNApSAcK:C00000956;   LINCS:LSM-20956;   LIPID_MAPS_instance:LMPK12020003;   MetaCyc:CPD-7630;   PMID:10427682;   PMID:7655336;   Reaxys:92760
 cyclic_relationship: is_enantiomer_of CHEBI:76125


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procyanidin B1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases expression ISO procyanidin B1 results in increased expression of ACOX1 mRNA CTD PMID:22227333 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of AKT protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of AKT protein CTD PMID:34342938 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO [[procyanidin B1 co-treated with procyanidin B3] co-treated with Catechin] results in increased expression of AQP3 mRNA CTD PMID:33294640 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Casp3 caspase 3 decreases expression ISO procyanidin B1 results in decreased expression of CASP3 mRNA CTD PMID:34684730 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases expression ISO procyanidin B1 results in increased expression of CAT protein CTD PMID:34684730 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO procyanidin B1 results in increased expression of CPT1A mRNA CTD PMID:22227333 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [p-coumaric acid co-treated with procyanidin B1] results in decreased expression of and results in decreased phosphorylation of GSK3B protein; procyanidin B1 results in decreased expression of and results in decreased phosphorylation of GSK3B protein CTD PMID:34342938 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gys2 glycogen synthase 2 multiple interactions
increases activity		 ISO [procyanidin B1 co-treated with p-coumaric acid] results in increased activity of GYS2 protein
procyanidin B1 results in increased activity of GYS2 protein		 CTD PMID:34342938 NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO procyanidin B1 results in increased expression of HMOX1 mRNA; procyanidin B1 results in increased expression of HMOX1 protein CTD PMID:30544155 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Insr insulin receptor multiple interactions
increases expression		 ISO [p-coumaric acid co-treated with procyanidin B1] results in increased expression of INSR protein
procyanidin B1 results in increased expression of INSR protein		 CTD PMID:34342938 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of IRS1 protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of IRS1 protein
[procyanidin B1 co-treated with p-coumaric acid] results in increased expression of and results in increased phosphorylation of IRS1 protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of IRS1 protein		 CTD PMID:34342938 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO procyanidin B1 binds to and results in decreased activity of KCNH1 protein CTD PMID:32533968 NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740 		JBrowse link
G Ly96 lymphocyte antigen 96 affects binding
multiple interactions		 ISO procyanidin B1 binds to [TLR4 protein binds to LY96 protein]
procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of LY96 mRNA]		 CTD PMID:26037075 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:26037075 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases ubiquitination
multiple interactions
increases expression		 ISO procyanidin B1 results in decreased ubiquitination of NFE2L2 protein
procyanidin B1 affects the localization of and results in increased activity of and results in increased stability of NFE2L2 protein
procyanidin B1 results in increased expression of NFE2L2 protein		 CTD PMID:30544155 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 mRNA]; procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 protein] CTD PMID:26037075 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression ISO procyanidin B1 results in increased expression of OGG1 mRNA; procyanidin B1 results in increased expression of OGG1 protein CTD PMID:34684730 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
decreases activity		 ISO [procyanidin B1 co-treated with p-coumaric acid] results in decreased activity of PCK1 protein
procyanidin B1 results in decreased activity of PCK1 protein		 CTD PMID:34342938 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO [p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of PIK3R1 protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of PIK3R1 protein CTD PMID:34342938 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 affects binding
decreases expression
decreases activity		 ISO procyanidin B1 binds to PTPN1 protein
procyanidin B1 results in decreased expression of PTPN1 mRNA; procyanidin B1 results in decreased expression of PTPN1 protein
procyanidin B1 results in decreased activity of PTPN1 protein		 CTD PMID:33992895 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Pygl glycogen phosphorylase L multiple interactions
decreases activity		 ISO [procyanidin B1 co-treated with p-coumaric acid] results in decreased activity of PYGL protein
procyanidin B1 results in decreased activity of PYGL protein		 CTD PMID:34342938 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
increases expression		 ISO [procyanidin B1 co-treated with p-coumaric acid] results in increased expression of SLC2A4 protein
procyanidin B1 results in increased expression of SLC2A4 protein		 CTD PMID:34342938 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions EXP procyanidin B1 promotes the reaction [Glutamic Acid results in increased expression of SLC3A2 mRNA] CTD PMID:25551766 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP procyanidin B1 promotes the reaction [Glutamic Acid results in increased expression of SLC7A11 mRNA] CTD PMID:25551766 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Tlr4 toll-like receptor 4 affects binding ISO procyanidin B1 binds to [TLR4 protein binds to LY96 protein] CTD PMID:26037075 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; procyanidin B1 inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:26037075 PMID:27473819 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO procyanidin B1 results in decreased expression of TRP53 mRNA; procyanidin B1 results in decreased expression of TRP53 protein CTD PMID:34684730 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA] CTD PMID:26037075 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO procyanidin B1 inhibits the reaction [Oxygen deficiency results in decreased expression of TXNRD1 protein] CTD PMID:35883890 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
procyanidin B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of AGER protein] CTD PMID:25199697 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO procyanidin B2 results in increased phosphorylation of AKT1 protein CTD PMID:21945981 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of ALB protein] CTD PMID:25199697 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of ATG12 mRNA CTD PMID:27057282 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression		 ISO procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of BAX protein]
procyanidin B2 affects the reaction [Diquat affects the expression of BAX mRNA]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]
procyanidin B2 results in decreased expression of BAX protein		 CTD PMID:21505870 PMID:27057282 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO procyanidin B2 affects the reaction [Diquat affects the expression of BCL2 mRNA]; procyanidin B2 affects the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA] CTD PMID:27057282 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO procyanidin B2 inhibits the reaction [Diquat results in increased expression of BCL2L11 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2L11 mRNA] CTD PMID:27057282 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of BECN1 mRNA CTD PMID:27057282 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO procyanidin B2 results in increased expression of BRCA1 mRNA CTD PMID:25839702 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of CASP1 protein] CTD PMID:30025709 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of CASP3 protein modified form]
3-methyladenine inhibits the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; procyanidin B2 inhibits the reaction [Diquat results in increased expression of CASP3 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]
procyanidin B2 results in decreased expression of CASP3 protein modified form		 CTD PMID:21505870 PMID:27057282 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases activity
multiple interactions		 ISO procyanidin B2 results in decreased activity of CASP9 protein
procyanidin B2 inhibits the reaction [MFGE8 protein results in increased activity of CASP9 protein]		 CTD PMID:21505870 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 procyanidin B2 inhibits the reaction [Diquat results in decreased activity of CAT protein]
procyanidin B2 inhibits the reaction [Carrageenan results in decreased activity of CAT protein]		 CTD PMID:27057282 PMID:28844677 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA] CTD PMID:25199697 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO procyanidin B2 results in increased expression of CDH1 mRNA CTD PMID:25839702 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions		 ISO procyanidin B2 affects the localization of CYCS protein
procyanidin B2 inhibits the reaction [MFGE8 protein affects the localization of CYCS protein]		 CTD PMID:21505870 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO procyanidin B2 results in increased expression of DNMT1 mRNA CTD PMID:25839702 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression ISO procyanidin B2 results in increased expression of DNMT3A mRNA CTD PMID:25839702 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta increases expression ISO procyanidin B2 results in increased expression of DNMT3B mRNA CTD PMID:25839702 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; procyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein]; procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO1 mRNA] CTD PMID:27057282 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions		 ISO procyanidin B2 results in increased expression of GSK3B protein modified form
procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]		 CTD PMID:21505870 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in decreased expression of HMOX1 protein] CTD PMID:28844677 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased secretion of IL10 protein] CTD PMID:28844677 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL18 mRNA]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL18 protein] CTD PMID:30025709 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]; procyanidin B2 inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:30025709 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased secretion of IL6 protein] CTD PMID:28844677 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of KLK3 protein] CTD PMID:28844677 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA CTD PMID:27057282 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO procyanidin B2 results in increased phosphorylation of MAPK1 protein CTD PMID:21945981 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO procyanidin B2 results in increased phosphorylation of MAPK3 protein CTD PMID:21945981 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing multiple interactions
affects response to substance		 ISO procyanidin B2 inhibits the reaction [MFGE8 protein affects the localization of CYCS protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased activity of CASP9 protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of BAX protein]; procyanidin B2 inhibits the reaction [MFGE8 protein results in increased expression of CASP3 protein modified form]
procyanidin B2 affects the susceptibility to MFGE8 protein		 CTD PMID:21505870 NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073 		JBrowse link
G Mir122 microRNA 122 decreases expression EXP
ISO		 procyanidin B2 results in decreased expression of MIR122 mRNA CTD PMID:24165878 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased activity of MPO protein] CTD PMID:30025709 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan affects the localization of NFE2L2 protein] CTD PMID:28844677 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of NLRP3 protein] CTD PMID:30025709 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS1 mRNA]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS1 protein] CTD PMID:25199697 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS2 mRNA]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of NPHS2 protein] CTD PMID:25199697 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in decreased expression of NQO1 protein] CTD PMID:28844677 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA; [Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA CTD PMID:27057282 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of PRKCA protein] CTD PMID:25199697 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 affects binding
decreases expression
decreases activity		 ISO procyanidin B2 binds to PTPN1 protein
procyanidin B2 results in decreased expression of PTPN1 mRNA; procyanidin B2 results in decreased expression of PTPN1 protein
procyanidin B2 results in decreased activity of PTPN1 protein		 CTD PMID:33992895 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP procyanidin B2 inhibits the reaction [Paraquat results in increased expression of PYCARD protein] CTD PMID:30025709 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Serpinb5 serpin family B member 5 increases expression ISO procyanidin B2 results in increased expression of SERPINB5 mRNA CTD PMID:25839702 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of TNF protein] CTD PMID:28844677 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO procyanidin B2 results in decreased activity of TOP2A protein CTD PMID:16536579 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity ISO procyanidin B2 results in decreased activity of UGT1A6 protein CTD PMID:35868516 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity ISO procyanidin B2 results in decreased activity of UGT1A9 protein CTD PMID:35868516 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases activity ISO procyanidin B2 results in decreased activity of UGT2B7 protein CTD PMID:35868516 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA] CTD PMID:25199697 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:25199697 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      chemical role 19439
        antioxidant 16157
          (-)-epicatechin 70
            (+)-gallocatechin-(4alpha->8)-(-)-epicatechin 0
            (-)-epicatechin-(4alpha->8)-(-)-epicatechin + 0
            (-)-epicatechin-(4beta->8)-(+)-gallocatechin 0
            (-)-epicatechin-(4beta->8)-(-)-epigallocatechin 0
            (-)-epicatechin-3-O-gallate 0
            (-)-epicatechin-5-gallate 0
            (-)-epigallocatechin-(4beta->8)-(-)-epicatechin 0
            3'-methylepicatechin-7-sulfate 0
            4'-O-methyl-(-)-epicatechin 0
            arecatannin B1 0
            epicatechin 3-O-(3'-O-methylgallate) 0
            epicatechin-3'-glucuronide 0
            epigallocatechin-(4beta->8,2beta->O-7)-epicatechin 0
            proanthocyanidin A2 0
            procyanidin B1 + 29
            procyanidin B2 + 49
            procyanidin B4 + 0
            procyanidin B5 0
            procyanidin B8 0
            procyanidin C1 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            organic molecule 19670
                              organic cyclic compound 19481
                                organic heterocyclic compound 18857
                                  oxacycle 17873
                                    benzopyran 11960
                                      1-benzopyran 11714
                                        flavonoid 7202
                                          flavans 3641
                                            hydroxyflavan 3381
                                              catechin 3360
                                                (-)-epicatechin 70
                                                  (+)-gallocatechin-(4alpha->8)-(-)-epicatechin 0
                                                  (-)-epicatechin-(4alpha->8)-(-)-epicatechin + 0
                                                  (-)-epicatechin-(4beta->8)-(+)-gallocatechin 0
                                                  (-)-epicatechin-(4beta->8)-(-)-epigallocatechin 0
                                                  (-)-epicatechin-3-O-gallate 0
                                                  (-)-epicatechin-5-gallate 0
                                                  (-)-epigallocatechin-(4beta->8)-(-)-epicatechin 0
                                                  3'-methylepicatechin-7-sulfate 0
                                                  4'-O-methyl-(-)-epicatechin 0
                                                  arecatannin B1 0
                                                  epicatechin 3-O-(3'-O-methylgallate) 0
                                                  epicatechin-3'-glucuronide 0
                                                  epigallocatechin-(4beta->8,2beta->O-7)-epicatechin 0
                                                  proanthocyanidin A2 0
                                                  procyanidin B1 + 29
                                                  procyanidin B2 + 49
                                                  procyanidin B4 + 0
                                                  procyanidin B5 0
                                                  procyanidin B8 0
                                                  procyanidin C1 0
paths to the root