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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:difenoconazole
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Accession:CHEBI:81760 term browser browse the term
Definition:A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms.
Synonyms:exact_synonym: 1-({2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole
 related_synonym: Formula=C19H17Cl2N3O3;   InChI=1S/C19H17Cl2N3O3/c1-13-9-25-19(27-13,10-24-12-22-11-23-24)17-7-6-16(8-18(17)21)26-15-4-2-14(20)3-5-15/h2-8,11-13H,9-10H2,1H3;   InChIKey=BQYJATMQXGBDHF-UHFFFAOYSA-N;   SMILES=CC1COC(Cn2cncn2)(O1)c1ccc(Oc2ccc(Cl)cc2)cc1Cl
 xref: CAS:119446-68-3;   KEGG:C18459
 xref_mesh: MESH:C115058
 xref: PMID:24405376;   PMID:25172726;   PMID:25306325;   PPDB:230;   Pesticides:difenoconazole;   Reaxys:9073356



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difenoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression EXP difenoconazole results in decreased expression of ABCA1 mRNA CTD PMID:28263823 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [dichlorfop-methyl co-treated with difenoconazole] results in decreased activity of ACHE protein CTD PMID:25419412 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX1 mRNA CTD PMID:33575850 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acox2 acyl-CoA oxidase 2 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX2 mRNA CTD PMID:33575850 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
JBrowse link
G Anxa10 annexin A10 increases expression ISO difenoconazole results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
JBrowse link
G Ar androgen receptor affects expression ISO difenoconazole affects the expression of AR mRNA CTD PMID:12711008 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 decreases expression ISO difenoconazole results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Arrdc4 arrestin domain containing 4 decreases expression EXP difenoconazole results in decreased expression of ARRDC4 mRNA CTD PMID:28263823 NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290
JBrowse link
G Cat catalase affects binding ISO difenoconazole binds to CAT protein CTD PMID:32278787 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdc42ep3 CDC42 effector protein 3 increases expression EXP difenoconazole results in increased expression of CDC42EP3 mRNA CTD PMID:28263823 NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO difenoconazole results in increased expression of CYP1A1 mRNA
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA
CTD PMID:32194361 PMID:33575850 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO [difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA
difenoconazole results in increased expression of CYP1A2 mRNA
CTD PMID:33575850 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions
ISO difenoconazole results in increased expression of CYP2B6 mRNA
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA
CTD PMID:33575850 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO difenoconazole results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO difenoconazole results in increased expression of CYP3A4 mRNA CTD PMID:33575850 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP
ISO
difenoconazole results in increased expression of CYP51 mRNA CTD PMID:28263823 PMID:29337257 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO difenoconazole results in decreased expression of CYP7A1 mRNA; difenoconazole results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP difenoconazole results in increased expression of DHCR7 mRNA CTD PMID:28263823 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP difenoconazole results in increased expression of FDFT1 mRNA CTD PMID:28263823 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Folh1 folate hydrolase 1 increases expression ISO difenoconazole results in increased expression of FOLH1 mRNA CTD PMID:12711008 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO difenoconazole results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP difenoconazole results in increased expression of HMGCR mRNA CTD PMID:28263823 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression EXP difenoconazole results in increased expression of HSD17B7 mRNA CTD PMID:28263823 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP difenoconazole results in increased expression of IDI1 mRNA CTD PMID:28263823 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Lhx1 LIM homeobox 1 increases expression EXP difenoconazole results in increased expression of LHX1 mRNA CTD PMID:28263823 NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of MLXIPL mRNA CTD PMID:33575850 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP difenoconazole results in increased expression of MSMO1 mRNA CTD PMID:28263823 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO difenoconazole results in decreased expression of NKX3-1 mRNA CTD PMID:12711008 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I2 mRNA CTD PMID:33575850 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA CTD PMID:33575850 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP difenoconazole results in increased expression of NSDHL mRNA CTD PMID:28263823 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142
JBrowse link
G Pgr progesterone receptor affects binding ISO difenoconazole binds to PGR protein CTD PMID:32278787 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO difenoconazole results in decreased expression of PMEPA1 mRNA CTD PMID:12711008 NCBI chr 3:162,011,884...162,060,137
Ensembl chr 3:162,012,751...162,060,454
JBrowse link
G Rarb retinoic acid receptor, beta increases expression EXP difenoconazole results in increased expression of RARB mRNA CTD PMID:28263823 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO difenoconazole binds to RORA protein CTD PMID:32278787 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP difenoconazole results in increased expression of SC5D mRNA CTD PMID:28263823 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 increases expression EXP difenoconazole results in increased expression of SEC61A2 mRNA CTD PMID:28263823 NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494
JBrowse link
G Sqle squalene epoxidase increases expression EXP difenoconazole results in increased expression of SQLE mRNA CTD PMID:28263823 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression EXP difenoconazole results in increased expression of STARD4 mRNA CTD PMID:28263823 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
JBrowse link
G Txnip thioredoxin interacting protein decreases expression EXP difenoconazole results in decreased expression of TXNIP mRNA CTD PMID:28263823 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link

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  CHEBI ontology 20072
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          difenoconazole 40
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                  main group element atom 19974
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                        carbon atom 19896
                          organic molecular entity 19896
                            organic molecule 19844
                              organic cyclic compound 19605
                                organic heterocyclic compound 18890
                                  heteroarene 16627
                                    monocyclic heteroarene 13619
                                      azole 12850
                                        triazoles 3725
                                          triazole antifungal agent 2394
                                            triazole fungicide 2375
                                              difenoconazole 40
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