CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: difenoconazole
Accession: CHEBI:81760
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Definition: A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms.
Synonyms: exact_synonym: 1-({2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole
related_synonym: Formula=C19H17Cl2N3O3; InChI=1S/C19H17Cl2N3O3/c1-13-9-25-19(27-13,10-24-12-22-11-23-24)17-7-6-16(8-18(17)21)26-15-4-2-14(20)3-5-15/h2-8,11-13H,9-10H2,1H3; InChIKey=BQYJATMQXGBDHF-UHFFFAOYSA-N; SMILES=CC1COC(Cn2cncn2)(O1)c1ccc(Oc2ccc(Cl)cc2)cc1Cl
xref: CAS:119446-68-3; KEGG:C18459
xref_mesh: MESH:C115058
xref: PMID:24405376; PMID:25172726; PMID:25306325; PPDB:230; Pesticides:difenoconazole; Reaxys:9073356
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Abca1
ATP binding cassette subfamily A member 1
decreases expression
EXP
difenoconazole results in decreased expression of ABCA1 mRNA
CTD
PMID:28263823
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Ache
acetylcholinesterase
multiple interactions
EXP
[dichlorfop-methyl co-treated with difenoconazole] results in decreased activity of ACHE protein
CTD
PMID:25419412
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acox1
acyl-CoA oxidase 1
multiple interactions
ISO
[difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX1 mRNA
CTD
PMID:33575850
NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
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Acox2
acyl-CoA oxidase 2
multiple interactions
ISO
[difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX2 mRNA
CTD
PMID:33575850
NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
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Anxa10
annexin A10
increases expression
ISO
difenoconazole results in increased expression of ANXA10 mRNA
CTD
PMID:32194361
NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
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Ar
androgen receptor
affects expression
ISO
difenoconazole affects the expression of AR mRNA
CTD
PMID:12711008
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arg1
arginase 1
decreases expression
ISO
difenoconazole results in decreased expression of ARG1 mRNA
CTD
PMID:32194361
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Arrdc4
arrestin domain containing 4
decreases expression
EXP
difenoconazole results in decreased expression of ARRDC4 mRNA
CTD
PMID:28263823
NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290
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Cat
catalase
affects binding
ISO
difenoconazole binds to CAT protein
CTD
PMID:32278787
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cdc42ep3
CDC42 effector protein 3
increases expression
EXP
difenoconazole results in increased expression of CDC42EP3 mRNA
CTD
PMID:28263823
NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression multiple interactions
ISO
difenoconazole results in increased expression of CYP1A1 mRNA [difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA
CTD
PMID:32194361 PMID:33575850
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions increases expression
ISO
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA difenoconazole results in increased expression of CYP1A2 mRNA
CTD
PMID:33575850
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression multiple interactions
ISO
difenoconazole results in increased expression of CYP2B6 mRNA [difenoconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA
CTD
PMID:33575850
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases expression
ISO
difenoconazole results in decreased expression of CYP2C19 protein
CTD
PMID:32194361
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
ISO
difenoconazole results in increased expression of CYP3A4 mRNA
CTD
PMID:33575850
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Cyp51
cytochrome P450, family 51
increases expression
EXP ISO
difenoconazole results in increased expression of CYP51 mRNA
CTD
PMID:28263823 PMID:29337257
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
difenoconazole results in decreased expression of CYP7A1 mRNA; difenoconazole results in decreased expression of CYP7A1 protein
CTD
PMID:32194361
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Dhcr7
7-dehydrocholesterol reductase
increases expression
EXP
difenoconazole results in increased expression of DHCR7 mRNA
CTD
PMID:28263823
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Fdft1
farnesyl diphosphate farnesyl transferase 1
increases expression
EXP
difenoconazole results in increased expression of FDFT1 mRNA
CTD
PMID:28263823
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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Folh1
folate hydrolase 1
increases expression
ISO
difenoconazole results in increased expression of FOLH1 mRNA
CTD
PMID:12711008
NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379
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G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
difenoconazole results in decreased expression of G6PC1 mRNA
CTD
PMID:32194361
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
increases expression
EXP
difenoconazole results in increased expression of HMGCR mRNA
CTD
PMID:28263823
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
increases expression
EXP
difenoconazole results in increased expression of HSD17B7 mRNA
CTD
PMID:28263823
NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
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Idi1
isopentenyl-diphosphate delta isomerase 1
increases expression
EXP
difenoconazole results in increased expression of IDI1 mRNA
CTD
PMID:28263823
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Lhx1
LIM homeobox 1
increases expression
EXP
difenoconazole results in increased expression of LHX1 mRNA
CTD
PMID:28263823
NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617
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Mlxipl
MLX interacting protein-like
multiple interactions
ISO
[difenoconazole co-treated with fludioxonil] results in decreased expression of MLXIPL mRNA
CTD
PMID:33575850
NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
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Msmo1
methylsterol monooxygenase 1
increases expression
EXP
difenoconazole results in increased expression of MSMO1 mRNA
CTD
PMID:28263823
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Nkx3-1
NK3 homeobox 1
decreases expression
ISO
difenoconazole results in decreased expression of NKX3-1 mRNA
CTD
PMID:12711008
NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
[difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I2 mRNA
CTD
PMID:33575850
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
ISO
[difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA
CTD
PMID:33575850
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nsdhl
NAD(P) dependent steroid dehydrogenase-like
increases expression
EXP
difenoconazole results in increased expression of NSDHL mRNA
CTD
PMID:28263823
NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142
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Pgr
progesterone receptor
affects binding
ISO
difenoconazole binds to PGR protein
CTD
PMID:32278787
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Pmepa1
prostate transmembrane protein, androgen induced 1
decreases expression
ISO
difenoconazole results in decreased expression of PMEPA1 mRNA
CTD
PMID:12711008
NCBI chr 3:162,011,884...162,060,137
Ensembl chr 3:162,012,751...162,060,454
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Rarb
retinoic acid receptor, beta
increases expression
EXP
difenoconazole results in increased expression of RARB mRNA
CTD
PMID:28263823
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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Rora
RAR-related orphan receptor A
affects binding
ISO
difenoconazole binds to RORA protein
CTD
PMID:32278787
NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
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Sc5d
sterol-C5-desaturase
increases expression
EXP
difenoconazole results in increased expression of SC5D mRNA
CTD
PMID:28263823
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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Sec61a2
SEC61 translocon subunit alpha 2
increases expression
EXP
difenoconazole results in increased expression of SEC61A2 mRNA
CTD
PMID:28263823
NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494
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Sqle
squalene epoxidase
increases expression
EXP
difenoconazole results in increased expression of SQLE mRNA
CTD
PMID:28263823
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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Stard4
StAR-related lipid transfer domain containing 4
increases expression
EXP
difenoconazole results in increased expression of STARD4 mRNA
CTD
PMID:28263823
NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
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Txnip
thioredoxin interacting protein
decreases expression
EXP
difenoconazole results in decreased expression of TXNIP mRNA
CTD
PMID:28263823
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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