CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: difenoconazole
Accession: CHEBI:81760
browse the term
Definition: A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms.
Synonyms: exact_synonym: 1-({2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole
related_synonym: Formula=C19H17Cl2N3O3; InChI=1S/C19H17Cl2N3O3/c1-13-9-25-19(27-13,10-24-12-22-11-23-24)17-7-6-16(8-18(17)21)26-15-4-2-14(20)3-5-15/h2-8,11-13H,9-10H2,1H3; InChIKey=BQYJATMQXGBDHF-UHFFFAOYSA-N; SMILES=CC1COC(Cn2cncn2)(O1)c1ccc(Oc2ccc(Cl)cc2)cc1Cl
xref: CAS:119446-68-3; KEGG:C18459
xref_mesh: MESH:C115058
xref: PMID:24405376; PMID:25172726; PMID:25306325; PPDB:230; Pesticides:difenoconazole; Reaxys:9073356
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Abca1
ATP binding cassette subfamily A member 1
decreases expression
EXP
difenoconazole results in decreased expression of ABCA1 mRNA
CTD
PMID:28263823
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcg8
ATP binding cassette subfamily G member 8
increases expression
ISO
difenoconazole results in increased expression of ABCG8 mRNA
CTD
PMID:34425431
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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Ache
acetylcholinesterase
multiple interactions
EXP
[dichlorfop-methyl co-treated with difenoconazole] results in decreased activity of ACHE protein
CTD
PMID:25419412
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acox1
acyl-CoA oxidase 1
multiple interactions
ISO
[difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX1 mRNA
CTD
PMID:33575850
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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Acox2
acyl-CoA oxidase 2
multiple interactions
ISO
[difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX2 mRNA
CTD
PMID:33575850
NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
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Acsl3
acyl-CoA synthetase long-chain family member 3
decreases expression
ISO
difenoconazole results in decreased expression of ACSL3 mRNA
CTD
PMID:34425431
NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
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Alpl
alkaline phosphatase, biomineralization associated
increases activity multiple interactions
EXP
difenoconazole results in increased activity of ALPL protein Quercetin inhibits the reaction [difenoconazole results in increased activity of ALPL protein]
CTD
PMID:28679351
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Anxa10
annexin A10
increases expression
ISO
difenoconazole results in increased expression of ANXA10 mRNA
CTD
PMID:32194361
NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
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Ar
androgen receptor
affects expression
ISO
difenoconazole affects the expression of AR mRNA
CTD
PMID:12711008
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arg1
arginase 1
decreases expression
ISO
difenoconazole results in decreased expression of ARG1 mRNA
CTD
PMID:32194361
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Arrdc4
arrestin domain containing 4
decreases expression
EXP
difenoconazole results in decreased expression of ARRDC4 mRNA
CTD
PMID:28263823
NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
EXP
difenoconazole results in increased expression of BAX mRNA ginger extract inhibits the reaction [difenoconazole results in increased expression of BAX mRNA]
CTD
PMID:34519103
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Casp3
caspase 3
multiple interactions increases expression
EXP
ginger extract inhibits the reaction [difenoconazole results in increased expression of CASP3 mRNA]
CTD
PMID:34519103
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
affects binding decreases activity multiple interactions
ISO EXP
difenoconazole binds to CAT protein difenoconazole results in decreased activity of CAT protein Quercetin inhibits the reaction [difenoconazole results in decreased activity of CAT protein]
CTD
PMID:28679351 PMID:32278787 PMID:34519103
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cdc42ep3
CDC42 effector protein 3
increases expression
EXP
difenoconazole results in increased expression of CDC42EP3 mRNA
CTD
PMID:28263823
NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721
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Cpt1a
carnitine palmitoyltransferase 1A
increases expression
ISO
difenoconazole results in increased expression of CPT1A mRNA
CTD
PMID:34425431
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
increases expression
ISO
difenoconazole results in increased expression of CYP17A1 mRNA
CTD
PMID:34425431
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression multiple interactions
ISO
difenoconazole results in increased expression of CYP1A1 mRNA [difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA
CTD
PMID:32194361 PMID:33575850
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions increases expression
ISO
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA difenoconazole results in increased expression of CYP1A2 mRNA
CTD
PMID:33575850 PMID:34425431
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression multiple interactions
ISO
difenoconazole results in increased expression of CYP2B6 mRNA [difenoconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA difenoconazole results in increased expression of CYP2B10 mRNA
CTD
PMID:33575850 PMID:34425431
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
increases expression
ISO
difenoconazole results in increased expression of CYP2C55 mRNA
CTD
PMID:34425431
NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases expression increases expression
ISO
difenoconazole results in decreased expression of CYP2C19 protein difenoconazole results in increased expression of CYP2C29 mRNA
CTD
PMID:32194361 PMID:34425431
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
decreases expression
ISO
difenoconazole results in decreased expression of CYP2J9 mRNA
CTD
PMID:34425431
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
ISO
difenoconazole results in increased expression of CYP3A4 mRNA
CTD
PMID:33575850
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp51
cytochrome P450, family 51
increases expression
EXP ISO
difenoconazole results in increased expression of CYP51 mRNA
CTD
PMID:28263823 PMID:29337257
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
difenoconazole results in decreased expression of CYP7A1 mRNA; difenoconazole results in decreased expression of CYP7A1 protein
CTD
PMID:32194361
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Dbi
diazepam binding inhibitor
decreases expression
ISO
difenoconazole results in decreased expression of DBI mRNA
CTD
PMID:34425431
NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
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Dgat1
diacylglycerol O-acyltransferase 1
increases expression
ISO
difenoconazole results in increased expression of DGAT1 mRNA
CTD
PMID:34425431
NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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Dgat2
diacylglycerol O-acyltransferase 2
increases expression
ISO
difenoconazole results in increased expression of DGAT2 mRNA
CTD
PMID:34425431
NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
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Dhcr7
7-dehydrocholesterol reductase
increases expression
EXP
difenoconazole results in increased expression of DHCR7 mRNA
CTD
PMID:28263823
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Fabp1
fatty acid binding protein 1
decreases expression
ISO
difenoconazole results in decreased expression of FABP1 mRNA
CTD
PMID:34425431
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fabp2
fatty acid binding protein 2
decreases expression
ISO
difenoconazole results in decreased expression of FABP2 mRNA
CTD
PMID:34425431
NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
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Fabp5
fatty acid binding protein 5
decreases expression
ISO
difenoconazole results in decreased expression of FABP5 mRNA
CTD
PMID:34425431
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
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Fdft1
farnesyl diphosphate farnesyl transferase 1
increases expression
EXP
difenoconazole results in increased expression of FDFT1 mRNA
CTD
PMID:28263823
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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Folh1
folate hydrolase 1
increases expression
ISO
difenoconazole results in increased expression of FOLH1 mRNA
CTD
PMID:12711008
NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379
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Fshb
follicle stimulating hormone subunit beta
decreases expression
EXP
difenoconazole results in decreased expression of FSHB protein
CTD
PMID:34519103
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
difenoconazole results in decreased expression of G6PC1 mRNA
CTD
PMID:32194361
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Gk
glycerol kinase
decreases expression
ISO
difenoconazole results in decreased expression of GK mRNA
CTD
PMID:34425431
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
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Got1
glutamic-oxaloacetic transaminase 1
increases activity multiple interactions
EXP
difenoconazole results in increased activity of GOT1 protein Quercetin inhibits the reaction [difenoconazole results in increased activity of GOT1 protein]
CTD
PMID:28679351
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpt
glutamic--pyruvic transaminase
multiple interactions increases activity
EXP ISO
Quercetin inhibits the reaction [difenoconazole results in increased activity of GPT protein]
CTD
PMID:28679351 PMID:34425431
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx1
glutathione peroxidase 1
decreases activity multiple interactions
EXP
difenoconazole results in decreased activity of GPX1 protein Quercetin inhibits the reaction [difenoconazole results in decreased activity of GPX1 protein]
CTD
PMID:28679351
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
increases expression
EXP
difenoconazole results in increased expression of HMGCR mRNA
CTD
PMID:28263823
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
decreases expression
ISO
difenoconazole results in decreased expression of HMGCS1 mRNA
CTD
PMID:34425431
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
increases expression
EXP
difenoconazole results in increased expression of HSD17B7 mRNA
CTD
PMID:28263823
NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
decreases activity
ISO
difenoconazole results in decreased activity of HSD3B1 protein
CTD
PMID:36965607
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
decreases activity
EXP
difenoconazole results in decreased activity of HSD3B2 protein
CTD
PMID:36965607
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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Idi1
isopentenyl-diphosphate delta isomerase 1
increases expression
EXP
difenoconazole results in increased expression of IDI1 mRNA
CTD
PMID:28263823
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Kcnn2
potassium calcium-activated channel subfamily N member 2
decreases expression
ISO
difenoconazole results in decreased expression of KCNN2 mRNA
CTD
PMID:34425431
NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
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Klk1c10
kallikrein 1-related peptidase C10
decreases expression
ISO
difenoconazole results in decreased expression of KLK3 mRNA
CTD
PMID:12711008
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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Ldha
lactate dehydrogenase A
increases activity multiple interactions
EXP
difenoconazole results in increased activity of LDHA protein Quercetin inhibits the reaction [difenoconazole results in increased activity of LDHA protein]
CTD
PMID:28679351
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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Lhb
luteinizing hormone subunit beta
decreases expression
EXP
difenoconazole results in decreased expression of LHB protein
CTD
PMID:34519103
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Lhx1
LIM homeobox 1
increases expression
EXP
difenoconazole results in increased expression of LHX1 mRNA
CTD
PMID:28263823
NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617
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Mki67
marker of proliferation Ki-67
multiple interactions increases expression
EXP
ginger extract inhibits the reaction [difenoconazole results in increased expression of MKI67 protein]
CTD
PMID:34519103
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mlxipl
MLX interacting protein-like
multiple interactions decreases expression
ISO
[difenoconazole co-treated with fludioxonil] results in decreased expression of MLXIPL mRNA difenoconazole results in decreased expression of MLXIPL mRNA
CTD
PMID:33575850 PMID:34425431
NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
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Msmo1
methylsterol monooxygenase 1
increases expression
EXP
difenoconazole results in increased expression of MSMO1 mRNA
CTD
PMID:28263823
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Nkx3-1
NK3 homeobox 1
decreases expression
ISO
difenoconazole results in decreased expression of NKX3-1 mRNA
CTD
PMID:12711008
NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
[difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I2 mRNA
CTD
PMID:33575850
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
ISO
[difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA
CTD
PMID:33575850
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nsdhl
NAD(P) dependent steroid dehydrogenase-like
increases expression
EXP
difenoconazole results in increased expression of NSDHL mRNA
CTD
PMID:28263823
NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142
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Pgr
progesterone receptor
affects binding
ISO
difenoconazole binds to PGR protein
CTD
PMID:32278787
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Pla2g12a
phospholipase A2, group XIIA
increases expression
ISO
difenoconazole results in increased expression of PLA2G12A mRNA
CTD
PMID:34425431
NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740
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Plin4
perilipin 4
decreases expression
ISO
difenoconazole results in decreased expression of PLIN4 mRNA
CTD
PMID:34425431
NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
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Pmepa1
prostate transmembrane protein, androgen induced 1
decreases expression
ISO
difenoconazole results in decreased expression of PMEPA1 mRNA
CTD
PMID:12711008
NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
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Ppara
peroxisome proliferator activated receptor alpha
decreases expression
ISO
difenoconazole results in decreased expression of PPARA mRNA
CTD
PMID:34425431
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
difenoconazole results in increased expression of PPARG protein
CTD
PMID:34425431
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Rarb
retinoic acid receptor, beta
increases expression
EXP
difenoconazole results in increased expression of RARB mRNA
CTD
PMID:28263823
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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Rora
RAR-related orphan receptor A
affects binding
ISO
difenoconazole binds to RORA protein
CTD
PMID:32278787
NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
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Sc5d
sterol-C5-desaturase
increases expression
EXP
difenoconazole results in increased expression of SC5D mRNA
CTD
PMID:28263823
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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Scd
stearoyl-CoA desaturase
decreases expression
ISO
difenoconazole results in decreased expression of SCD1 mRNA
CTD
PMID:34425431
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Sec61a2
SEC61 translocon subunit alpha 2
increases expression
EXP
difenoconazole results in increased expression of SEC61A2 mRNA
CTD
PMID:28263823
NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494
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Slco1a4
solute carrier organic anion transporter family, member 1a4
increases expression
ISO
difenoconazole results in increased expression of SLCO1A4 mRNA
CTD
PMID:34425431
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Sod1
superoxide dismutase 1
multiple interactions decreases activity
EXP
Quercetin inhibits the reaction [difenoconazole results in decreased activity of SOD1 protein]
CTD
PMID:28679351
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sqle
squalene epoxidase
increases expression
EXP
difenoconazole results in increased expression of SQLE mRNA
CTD
PMID:28263823
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
ISO
difenoconazole results in decreased expression of SREBF1 mRNA; difenoconazole results in decreased expression of SREBF1 protein
CTD
PMID:34425431
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Star
steroidogenic acute regulatory protein
decreases activity
EXP
difenoconazole results in decreased activity of STAR protein
CTD
PMID:34519103
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stard4
StAR-related lipid transfer domain containing 4
increases expression
EXP
difenoconazole results in increased expression of STARD4 mRNA
CTD
PMID:28263823
NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
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Sult1e1
sulfotransferase family 1E member 1
increases expression
ISO
difenoconazole results in increased expression of SULT1E1 mRNA
CTD
PMID:34425431
NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
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Txnip
thioredoxin interacting protein
decreases expression
EXP
difenoconazole results in decreased expression of TXNIP mRNA
CTD
PMID:28263823
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases expression
ISO
difenoconazole results in increased expression of UGT1A9 mRNA
CTD
PMID:34425431
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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