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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:difenoconazole
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Accession:CHEBI:81760 term browser browse the term
Definition:A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms.
Synonyms:exact_synonym: 1-({2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole
 related_synonym: Formula=C19H17Cl2N3O3;   InChI=1S/C19H17Cl2N3O3/c1-13-9-25-19(27-13,10-24-12-22-11-23-24)17-7-6-16(8-18(17)21)26-15-4-2-14(20)3-5-15/h2-8,11-13H,9-10H2,1H3;   InChIKey=BQYJATMQXGBDHF-UHFFFAOYSA-N;   SMILES=CC1COC(Cn2cncn2)(O1)c1ccc(Oc2ccc(Cl)cc2)cc1Cl
 xref: CAS:119446-68-3;   KEGG:C18459
 xref_mesh: MESH:C115058
 xref: PMID:24405376;   PMID:25172726;   PMID:25306325;   PPDB:230;   Pesticides:difenoconazole;   Reaxys:9073356

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difenoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression EXP difenoconazole results in decreased expression of ABCA1 mRNA CTD PMID:28263823 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [dichlorfop-methyl co-treated with difenoconazole] results in decreased activity of ACHE protein CTD PMID:25419412 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX1 mRNA CTD PMID:33575850 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Acox2 acyl-CoA oxidase 2 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX2 mRNA CTD PMID:33575850 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470 		JBrowse link
G Anxa10 annexin A10 increases expression ISO difenoconazole results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465 		JBrowse link
G Ar androgen receptor affects expression ISO difenoconazole affects the expression of AR mRNA CTD PMID:12711008 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Arg1 arginase 1 decreases expression ISO difenoconazole results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Arrdc4 arrestin domain containing 4 decreases expression EXP difenoconazole results in decreased expression of ARRDC4 mRNA CTD PMID:28263823 NCBI chr 1:129,766,097...129,780,076
Ensembl chr 1:129,766,100...129,780,356 		JBrowse link
G Cat catalase affects binding ISO difenoconazole binds to CAT protein CTD PMID:32278787 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cdc42ep3 CDC42 effector protein 3 increases expression EXP difenoconazole results in increased expression of CDC42EP3 mRNA CTD PMID:28263823 NCBI chr 6:1,922,500...1,942,972
Ensembl chr 6:1,922,500...1,942,972 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO difenoconazole results in increased expression of CYP1A1 mRNA
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA		 CTD PMID:32194361 PMID:33575850 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO [difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA
difenoconazole results in increased expression of CYP1A2 mRNA		 CTD PMID:33575850 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions		 ISO difenoconazole results in increased expression of CYP2B6 mRNA
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA		 CTD PMID:33575850 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO difenoconazole results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP
ISO		 difenoconazole results in increased expression of CYP51 mRNA CTD PMID:28263823 PMID:29337257 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO difenoconazole results in decreased expression of CYP7A1 mRNA; difenoconazole results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP difenoconazole results in increased expression of DHCR7 mRNA CTD PMID:28263823 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP difenoconazole results in increased expression of FDFT1 mRNA CTD PMID:28263823 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302 		JBrowse link
G Folh1 folate hydrolase 1 increases expression ISO difenoconazole results in increased expression of FOLH1 mRNA CTD PMID:12711008 NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO difenoconazole results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP difenoconazole results in increased expression of HMGCR mRNA CTD PMID:28263823 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression EXP difenoconazole results in increased expression of HSD17B7 mRNA CTD PMID:28263823 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP difenoconazole results in increased expression of IDI1 mRNA CTD PMID:28263823 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036 		JBrowse link
G Lhx1 LIM homeobox 1 increases expression EXP difenoconazole results in increased expression of LHX1 mRNA CTD PMID:28263823 NCBI chr10:71,843,991...71,849,293
Ensembl chr10:71,843,991...71,849,293 		JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of MLXIPL mRNA CTD PMID:33575850 NCBI chr12:24,590,645...24,619,639 JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP difenoconazole results in increased expression of MSMO1 mRNA CTD PMID:28263823 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973 		JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO difenoconazole results in decreased expression of NKX3-1 mRNA CTD PMID:12711008 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I2 mRNA CTD PMID:33575850 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA CTD PMID:33575850 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP difenoconazole results in increased expression of NSDHL mRNA CTD PMID:28263823 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390 		JBrowse link
G Pgr progesterone receptor affects binding ISO difenoconazole binds to PGR protein CTD PMID:32278787 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO difenoconazole results in decreased expression of PMEPA1 mRNA CTD PMID:12711008 NCBI chr 3:171,295,630...171,342,662
Ensembl chr 3:171,294,856...171,342,646 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression EXP difenoconazole results in increased expression of RARB mRNA CTD PMID:28263823 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599 		JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO difenoconazole binds to RORA protein CTD PMID:32278787 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP difenoconazole results in increased expression of SC5D mRNA CTD PMID:28263823 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050 		JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 increases expression EXP difenoconazole results in increased expression of SEC61A2 mRNA CTD PMID:28263823 NCBI chr17:76,358,947...76,385,860
Ensembl chr17:76,358,944...76,385,103 		JBrowse link
G Sqle squalene epoxidase increases expression EXP difenoconazole results in increased expression of SQLE mRNA CTD PMID:28263823 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression EXP difenoconazole results in increased expression of STARD4 mRNA CTD PMID:28263823 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression EXP difenoconazole results in decreased expression of TXNIP mRNA CTD PMID:28263823 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
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  CHEBI ontology 19786
    role 19732
      biological role 19732
        xenobiotic 18425
          difenoconazole 39
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  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic molecule 19519
                              organic cyclic compound 19349
                                organic heterocyclic compound 18574
                                  heteroarene 16526
                                    monocyclic heteroarene 13396
                                      azole 12575
                                        triazoles 3648
                                          triazole antifungal agent 2363
                                            triazole fungicide 2347
                                              difenoconazole 39
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