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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:difenoconazole
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Accession:CHEBI:81760 term browser browse the term
Definition:A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms.
Synonyms:exact_synonym: 1-({2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole
 related_synonym: Formula=C19H17Cl2N3O3;   InChI=1S/C19H17Cl2N3O3/c1-13-9-25-19(27-13,10-24-12-22-11-23-24)17-7-6-16(8-18(17)21)26-15-4-2-14(20)3-5-15/h2-8,11-13H,9-10H2,1H3;   InChIKey=BQYJATMQXGBDHF-UHFFFAOYSA-N;   SMILES=CC1COC(Cn2cncn2)(O1)c1ccc(Oc2ccc(Cl)cc2)cc1Cl
 xref: CAS:119446-68-3;   KEGG:C18459
 xref_mesh: MESH:C115058
 xref: PMID:24405376;   PMID:25172726;   PMID:25306325;   PPDB:230;   Pesticides:difenoconazole;   Reaxys:9073356


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difenoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression EXP difenoconazole results in decreased expression of ABCA1 mRNA CTD PMID:28263823 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [dichlorfop-methyl co-treated with difenoconazole] results in decreased activity of ACHE protein CTD PMID:25419412 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX1 mRNA CTD PMID:33575850 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acox2 acyl-CoA oxidase 2 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX2 mRNA CTD PMID:33575850 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160 		JBrowse link
G Anxa10 annexin A10 increases expression ISO difenoconazole results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648 		JBrowse link
G Ar androgen receptor affects expression ISO difenoconazole affects the expression of AR mRNA CTD PMID:12711008 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arg1 arginase 1 decreases expression ISO difenoconazole results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Arrdc4 arrestin domain containing 4 decreases expression EXP difenoconazole results in decreased expression of ARRDC4 mRNA CTD PMID:28263823 NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290 		JBrowse link
G Cat catalase affects binding ISO difenoconazole binds to CAT protein CTD PMID:32278787 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdc42ep3 CDC42 effector protein 3 increases expression EXP difenoconazole results in increased expression of CDC42EP3 mRNA CTD PMID:28263823 NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO difenoconazole results in increased expression of CYP1A1 mRNA
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA		 CTD PMID:32194361 PMID:33575850 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO [difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA
difenoconazole results in increased expression of CYP1A2 mRNA		 CTD PMID:33575850 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions		 ISO difenoconazole results in increased expression of CYP2B6 mRNA
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA		 CTD PMID:33575850 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO difenoconazole results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO difenoconazole results in increased expression of CYP3A4 mRNA CTD PMID:33575850 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP
ISO		 difenoconazole results in increased expression of CYP51 mRNA CTD PMID:28263823 PMID:29337257 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO difenoconazole results in decreased expression of CYP7A1 mRNA; difenoconazole results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP difenoconazole results in increased expression of DHCR7 mRNA CTD PMID:28263823 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP difenoconazole results in increased expression of FDFT1 mRNA CTD PMID:28263823 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Folh1 folate hydrolase 1 increases expression ISO difenoconazole results in increased expression of FOLH1 mRNA CTD PMID:12711008 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO difenoconazole results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP difenoconazole results in increased expression of HMGCR mRNA CTD PMID:28263823 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression EXP difenoconazole results in increased expression of HSD17B7 mRNA CTD PMID:28263823 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP difenoconazole results in increased expression of IDI1 mRNA CTD PMID:28263823 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Lhx1 LIM homeobox 1 increases expression EXP difenoconazole results in increased expression of LHX1 mRNA CTD PMID:28263823 NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617 		JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of MLXIPL mRNA CTD PMID:33575850 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP difenoconazole results in increased expression of MSMO1 mRNA CTD PMID:28263823 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO difenoconazole results in decreased expression of NKX3-1 mRNA CTD PMID:12711008 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I2 mRNA CTD PMID:33575850 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA CTD PMID:33575850 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP difenoconazole results in increased expression of NSDHL mRNA CTD PMID:28263823 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142 		JBrowse link
G Pgr progesterone receptor affects binding ISO difenoconazole binds to PGR protein CTD PMID:32278787 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO difenoconazole results in decreased expression of PMEPA1 mRNA CTD PMID:12711008 NCBI chr 3:162,011,884...162,060,137
Ensembl chr 3:162,012,751...162,060,454 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression EXP difenoconazole results in increased expression of RARB mRNA CTD PMID:28263823 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO difenoconazole binds to RORA protein CTD PMID:32278787 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP difenoconazole results in increased expression of SC5D mRNA CTD PMID:28263823 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273 		JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 increases expression EXP difenoconazole results in increased expression of SEC61A2 mRNA CTD PMID:28263823 NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494 		JBrowse link
G Sqle squalene epoxidase increases expression EXP difenoconazole results in increased expression of SQLE mRNA CTD PMID:28263823 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression EXP difenoconazole results in increased expression of STARD4 mRNA CTD PMID:28263823 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression EXP difenoconazole results in decreased expression of TXNIP mRNA CTD PMID:28263823 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
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          difenoconazole 40
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                        carbon atom 19896
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                            organic molecule 19844
                              organic cyclic compound 19605
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                                              difenoconazole 40
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