CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: antimony(0)
Accession: CHEBI:30304
browse the term
Definition: An elemental antimony that has formula Sb.
Synonyms: exact_synonym: antimony
related_synonym: Antimony, metallic; Formula=Sb; Sb(0); Sbn; Stibium metallicum
xref: CAS:7440-36-0; Gmelin:16305
xref_mesh: MESH:D000965
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A2m
alpha-2-macroglobulin
decreases expression
ISO
Antimony results in decreased expression of A2M mRNA
CTD
PMID:17547211
NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
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Abcc1
ATP-binding cassette, sub-family C member 1
decreases response to substance multiple interactions
ISO
ABCC1 protein results in decreased susceptibility to Antimony; ABCC1 protein results in decreased susceptibility to Antimony analog GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to Antimony]
CTD
PMID:7954421 PMID:11560771
NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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Acp2
acid phosphatase 2, lysosomal
decreases expression
ISO
Antimony results in decreased expression of ACP2 mRNA
CTD
PMID:17547211
NCBI chr 2:91,033,157...91,044,443
Ensembl chr 2:91,033,230...91,044,443
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Acsl1
acyl-CoA synthetase long-chain family member 1
decreases expression
ISO
Antimony results in decreased expression of ACSL1 mRNA
CTD
PMID:17547211
NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088
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Adm
adrenomedullin
increases expression
ISO
Antimony results in increased expression of ADM mRNA
CTD
PMID:17547211
NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
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Akr1b1
aldo-keto reductase family 1 member B
decreases expression
ISO
Antimony results in decreased expression of AKR1B1 mRNA
CTD
PMID:17547211
NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
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Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
decreases expression
ISO
Antimony results in decreased expression of ALDH6A1 mRNA
CTD
PMID:17547211
NCBI chr12:84,477,491...84,497,798
Ensembl chr12:84,477,491...84,497,778
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Aqp9
aquaporin 9
multiple interactions
ISO
AQP9 protein results in increased uptake of and results in increased susceptibility to Antimony
CTD
PMID:15336539
NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964
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Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
decreases expression
ISO
Antimony results in decreased expression of ATP2B1 mRNA
CTD
PMID:17547211
NCBI chr10:98,750,243...98,862,005
Ensembl chr10:98,750,268...98,862,005
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Azgp1
alpha-2-glycoprotein 1, zinc
decreases expression
ISO
Antimony results in decreased expression of AZGP1 mRNA
CTD
PMID:17547211
NCBI chr 5:137,979,783...137,988,495
Ensembl chr 5:137,979,782...137,988,495
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Bax
BCL2-associated X protein
multiple interactions
EXP
[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of BAX protein
CTD
PMID:32920012
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Bcl2
B cell leukemia/lymphoma 2
multiple interactions
EXP ISO
[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in decreased expression of BCL2 protein 666-15 compound promotes the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in decreased expression of BCL2 protein]; [Antimony Potassium Tartrate results in increased abundance of Antimony] which results in decreased expression of BCL2 protein
CTD
PMID:32920012
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Casp3
caspase 3
multiple interactions
ISO EXP
[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased cleavage of CASP3 protein
CTD
PMID:32920012
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Ccl2
C-C motif chemokine ligand 2
increases expression
EXP
Antimony results in increased expression of CCL2 mRNA
CTD
PMID:37858840
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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Ccnb2
cyclin B2
increases expression
ISO
Antimony results in increased expression of CCNB2 mRNA
CTD
PMID:17547211
NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
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Ccnd1
cyclin D1
multiple interactions
ISO
666-15 compound inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of CCND1 protein]; [Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of CCND1 protein; SB 203580 inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of CCND1 protein]; U 0126 inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of CCND1 protein]
CTD
PMID:34571074
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Cdkn1a
cyclin dependent kinase inhibitor 1A
increases expression decreases expression
ISO EXP
Antimony results in increased expression of CDKN1A mRNA Antimony results in decreased expression of CDKN1A mRNA
CTD
PMID:17547211 PMID:37858840
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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Cdkn3
cyclin dependent kinase inhibitor 3
increases expression
ISO
Antimony results in increased expression of CDKN3 mRNA
CTD
PMID:17547211
NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126
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Cebpb
CCAAT/enhancer binding protein beta
increases expression
EXP
Antimony results in increased expression of CEBPB protein
CTD
PMID:37858840
NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
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Cfb
complement factor B
decreases expression
ISO
Antimony results in decreased expression of CFB mRNA
CTD
PMID:17547211
NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494
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Chuk
conserved helix-loop-helix ubiquitous kinase
multiple interactions
EXP
Antimony results in increased phosphorylation of [CHUK protein co-treated with IKBKB protein]
CTD
PMID:37858840
NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
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Cks2
CDC28 protein kinase regulatory subunit 2
increases expression
ISO
Antimony results in increased expression of CKS2 mRNA
CTD
PMID:17547211
NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696
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Clgn
calmegin
decreases expression
ISO
Antimony results in decreased expression of CLGN mRNA
CTD
PMID:17547211
NCBI chr 8:84,116,454...84,155,181
Ensembl chr 8:84,116,496...84,155,181
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Clptm1
cleft lip and palate associated transmembrane protein 1
decreases expression
ISO
Antimony results in decreased expression of CLPTM1 mRNA
CTD
PMID:17547211
NCBI chr 7:19,365,505...19,398,955
Ensembl chr 7:19,365,496...19,398,958
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Creb1
cAMP responsive element binding protein 1
multiple interactions
ISO EXP
[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased phosphorylation of CREB1 protein; pyrazolanthrone inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased phosphorylation of CREB1 protein]; U 0126 inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased phosphorylation of CREB1 protein]
CTD
PMID:32920012 PMID:34571074
NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
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Cxcl15
C-X-C motif chemokine ligand 15
increases expression
EXP
Antimony results in increased expression of CXCL8 mRNA
CTD
PMID:37858840
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Dazap1
DAZ associated protein 1
increases expression
ISO
Antimony results in increased expression of DAZAP1 mRNA
CTD
PMID:17547211
NCBI chr10:80,097,168...80,124,242
Ensembl chr10:80,097,320...80,124,242
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Dcp1a
decapping mRNA 1A
increases expression
ISO
Antimony results in increased expression of DCP1A mRNA
CTD
PMID:17547211
NCBI chr14:30,201,613...30,249,013
Ensembl chr14:30,201,492...30,249,020
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Ddit3
DNA-damage inducible transcript 3
increases expression
EXP
Antimony results in increased expression of DDIT3 mRNA
CTD
PMID:37858840
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
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Dusp1
dual specificity phosphatase 1
increases expression
ISO
Antimony results in increased expression of DUSP1 mRNA
CTD
PMID:17547211
NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
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Eif2a
eukaryotic translation initiation factor 2A
increases phosphorylation
EXP
Antimony results in increased phosphorylation of EIF2A protein
CTD
PMID:37858840
NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922
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F5
coagulation factor V
decreases expression
ISO
Antimony results in decreased expression of F5 mRNA
CTD
PMID:17547211
NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846
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Fabp4
fatty acid binding protein 4, adipocyte
increases expression
EXP
Antimony results in increased expression of FABP4 mRNA
CTD
PMID:37858840
NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
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Fasn
fatty acid synthase
increases expression
EXP
Antimony results in increased expression of FASN mRNA
CTD
PMID:37858840
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
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Fdft1
farnesyl diphosphate farnesyl transferase 1
decreases expression
ISO
Antimony results in decreased expression of FDFT1 mRNA
CTD
PMID:17547211
NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
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Fdps
farnesyl diphosphate synthetase
decreases expression
ISO
Antimony results in decreased expression of FDPS mRNA
CTD
PMID:17547211
NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266
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Fosl1
fos-like antigen 1
increases expression
ISO
Antimony results in increased expression of FOSL1 mRNA
CTD
PMID:17547211
NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
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Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
ISO
GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to Antimony]
CTD
PMID:11560771
NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
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Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
increases expression
ISO
Antimony results in increased expression of GCNT3 mRNA
CTD
PMID:17547211
NCBI chr 9:69,938,777...69,947,172
Ensembl chr 9:69,938,778...69,945,370
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Gfap
glial fibrillary acidic protein
multiple interactions
EXP ISO
[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of GFAP protein 666-15 compound inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of GFAP protein]; [Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of GFAP mRNA; [Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of GFAP protein; SB 203580 inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of GFAP mRNA]; SB 203580 inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of GFAP protein]; U 0126 inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of GFAP mRNA]
CTD
PMID:34571074
NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
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Ghitm
growth hormone inducible transmembrane protein
decreases expression
ISO
Antimony results in decreased expression of GHITM mRNA
CTD
PMID:17547211
NCBI chr14:36,842,401...36,857,279
Ensembl chr14:36,842,049...36,857,229
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Gla
galactosidase, alpha
increases expression
ISO
Antimony results in increased expression of GLA mRNA
CTD
PMID:17547211
NCBI chr X:133,488,912...133,501,707
Ensembl chr X:133,488,898...133,501,874
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Gpx4
glutathione peroxidase 4
multiple interactions decreases expression
EXP ISO
ferrostatin-1 inhibits the reaction [Antimony results in decreased expression of GPX4 protein] Acetylcysteine inhibits the reaction [Antimony results in decreased expression of GPX4 protein]; Antimony results in decreased expression of and results in increased localization of and results in increased degradation of GPX4 protein; Chloroquine inhibits the reaction [Antimony results in decreased expression of GPX4 protein]; Cyclophosphamide promotes the reaction [Antimony results in decreased expression of and results in increased degradation of GPX4 protein]; MCOLN1 protein inhibits the reaction [Antimony results in decreased expression of GPX4 protein]; MCOLN1 protein promotes the reaction [Antimony results in increased degradation of GPX4 protein]
CTD
PMID:38097005
NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
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Gtpbp6
GTP binding protein 6 (putative)
increases expression
ISO
Antimony results in increased expression of GTPBP6 mRNA
CTD
PMID:17547211
NCBI chr 5:110,251,842...110,256,063
Ensembl chr 5:110,251,841...110,256,063
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H4c14
H4 clustered histone 14
increases expression
ISO
Antimony results in increased expression of H4C3 mRNA
CTD
PMID:17547211
NCBI chr 3:96,170,250...96,170,633
Ensembl chr 3:96,168,998...96,170,627
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Havcr1
hepatitis A virus cellular receptor 1
multiple interactions increases expression
ISO EXP
Acetylcysteine inhibits the reaction [Antimony results in increased expression of HAVCR1 protein]; MCOLN1 protein inhibits the reaction [Antimony results in increased expression of HAVCR1 protein] ferrostatin-1 inhibits the reaction [Antimony results in increased expression of HAVCR1 protein]
CTD
PMID:38097005
NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
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Hmga1
high mobility group AT-hook 1
increases expression
ISO
Antimony results in increased expression of HMGA1 mRNA
CTD
PMID:17547211
NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648
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Hmox1
heme oxygenase 1
increases expression
ISO
Antimony results in increased expression of HMOX1 mRNA
CTD
PMID:17547211
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
decreases expression
ISO
Antimony results in decreased expression of HSD17B2 mRNA
CTD
PMID:17547211
NCBI chr 8:118,427,752...118,485,767
Ensembl chr 8:118,428,643...118,485,766
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Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
decreases expression
ISO
Antimony results in decreased expression of HSD17B7 mRNA
CTD
PMID:17547211
NCBI chr 1:169,777,109...169,796,757
Ensembl chr 1:169,777,104...169,796,810
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Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
increases expression multiple interactions
ISO
Antimony results in increased expression of HSP90AA1 protein MCOLN1 protein inhibits the reaction [Antimony results in increased expression of HSP90AA1 protein]
CTD
PMID:38097005
NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162
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Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
increases expression multiple interactions
ISO
Antimony results in increased expression of HSP90AB1 protein MCOLN1 protein inhibits the reaction [Antimony results in increased expression of HSP90AB1 protein]
CTD
PMID:38097005
NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197
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Hspa5
heat shock protein 5
increases expression
EXP
Antimony results in increased expression of HSPA5 mRNA
CTD
PMID:37858840
NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
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Hspa8
heat shock protein 8
multiple interactions increases expression
ISO
MCOLN1 protein inhibits the reaction [Antimony results in increased expression of HSPA8 protein]
CTD
PMID:38097005
NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383
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Ier2
immediate early response 2
increases expression
ISO
Antimony results in increased expression of IER2 mRNA
CTD
PMID:17547211
NCBI chr 8:85,387,960...85,389,481
Ensembl chr 8:85,387,960...85,389,483
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Ifng
interferon gamma
affects response to substance
EXP
IFNG protein affects the susceptibility to Antimony
CTD
PMID:11035738
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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Ifrd1
interferon-related developmental regulator 1
decreases expression
ISO
Antimony results in decreased expression of IFRD1 mRNA
CTD
PMID:17547211
NCBI chr12:40,253,128...40,273,184
Ensembl chr12:40,251,566...40,298,503
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Ikbkb
inhibitor of kappaB kinase beta
multiple interactions
EXP
Antimony results in increased phosphorylation of [CHUK protein co-treated with IKBKB protein]
CTD
PMID:37858840
NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
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Il12a
interleukin 12a
affects response to substance
EXP
IL12A protein affects the susceptibility to Antimony
CTD
PMID:11023473
NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
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Il12b
interleukin 12b
affects response to substance
EXP
IL12B protein affects the susceptibility to Antimony
CTD
PMID:11023473
NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
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Il6
interleukin 6
increases expression
EXP
Antimony results in increased expression of IL6 mRNA
CTD
PMID:37858840
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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Ing3
inhibitor of growth family, member 3
increases expression
ISO
Antimony results in increased expression of ING3 mRNA
CTD
PMID:17547211
NCBI chr 6:21,948,002...21,976,037
Ensembl chr 6:21,949,570...21,976,037
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Itgb3bp
integrin beta 3 binding protein (beta3-endonexin)
increases expression
ISO
Antimony results in increased expression of ITGB3BP mRNA
CTD
PMID:17547211
NCBI chr 4:99,655,643...99,717,403
Ensembl chr 4:99,653,639...99,787,010
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Itih3
inter-alpha trypsin inhibitor, heavy chain 3
decreases expression
ISO
Antimony results in decreased expression of ITIH3 mRNA
CTD
PMID:17547211
NCBI chr14:30,630,529...30,645,748
Ensembl chr14:30,630,529...30,645,717
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Klf6
Kruppel-like transcription factor 6
increases expression
ISO
Antimony results in increased expression of KLF6 mRNA
CTD
PMID:17547211
NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393
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Lamp2
lysosomal-associated membrane protein 2
multiple interactions increases expression
ISO
MCOLN1 protein inhibits the reaction [Antimony results in increased expression of LAMP2 protein]
CTD
PMID:38097005
NCBI chr X:37,488,524...37,545,337
Ensembl chr X:37,490,234...37,545,331
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Lipa
lysosomal acid lipase A
decreases expression
ISO
Antimony results in decreased expression of LIPA mRNA
CTD
PMID:17547211
NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874
G
Lrrk2
leucine-rich repeat kinase 2
decreases expression multiple interactions
ISO
Antimony results in decreased expression of LRRK2 protein MCOLN1 protein inhibits the reaction [Antimony results in decreased expression of LRRK2 protein]
CTD
PMID:38097005
NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323
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Lss
lanosterol synthase
decreases expression
ISO
Antimony results in decreased expression of LSS mRNA
CTD
PMID:17547211
NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972
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Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
increases expression
ISO
Antimony results in increased expression of MAFF mRNA
CTD
PMID:17547211
NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276
G
Man1a2
mannosidase, alpha, class 1A, member 2
decreases expression
ISO
Antimony results in decreased expression of MAN1A2 mRNA
CTD
PMID:17547211
NCBI chr 3:100,469,519...100,592,789
Ensembl chr 3:100,469,524...100,592,819
G
Mapk1
mitogen-activated protein kinase 1
multiple interactions
ISO
[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased phosphorylation of MAPK1 protein
CTD
PMID:32920012 PMID:34571074
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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Mapk3
mitogen-activated protein kinase 3
multiple interactions
ISO
[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased phosphorylation of MAPK3 protein
CTD
PMID:32920012 PMID:34571074
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
G
Mcm2
minichromosome maintenance complex component 2
increases expression
ISO
Antimony results in increased expression of MCM2 mRNA
CTD
PMID:17547211
NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762
G
Mcoln1
mucolipin 1
decreases expression multiple interactions
ISO EXP
Antimony results in decreased expression of MCOLN1 protein MCOLN1 protein inhibits the reaction [Antimony results in decreased expression of GPX4 protein]; MCOLN1 protein inhibits the reaction [Antimony results in decreased expression of LRRK2 protein]; MCOLN1 protein inhibits the reaction [Antimony results in decreased expression of MEF2D protein]; MCOLN1 protein inhibits the reaction [Antimony results in decreased expression of SOD1 protein]; MCOLN1 protein inhibits the reaction [Antimony results in increased expression of HAVCR1 protein]; MCOLN1 protein inhibits the reaction [Antimony results in increased expression of HSP90AA1 protein]; MCOLN1 protein inhibits the reaction [Antimony results in increased expression of HSP90AB1 protein]; MCOLN1 protein inhibits the reaction [Antimony results in increased expression of HSPA8 protein]; MCOLN1 protein inhibits the reaction [Antimony results in increased expression of LAMP2 protein]; MCOLN1 protein inhibits the reaction [Antimony results in increased expression of PTGS2 protein]; MCOLN1 protein promotes the reaction [Antimony results in increased degradation of GPX4 protein]
CTD
PMID:38097005
NCBI chr 8:3,550,458...3,565,232
Ensembl chr 8:3,550,457...3,565,232
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Mef2d
myocyte enhancer factor 2D
decreases expression multiple interactions
ISO
Antimony results in decreased expression of MEF2D protein MCOLN1 protein inhibits the reaction [Antimony results in decreased expression of MEF2D protein]
CTD
PMID:38097005
NCBI chr 3:88,049,248...88,079,398
Ensembl chr 3:88,049,679...88,079,393
G
Mgat2
mannoside acetylglucosaminyltransferase 2
decreases expression
ISO
Antimony results in decreased expression of MGAT2 mRNA
CTD
PMID:17547211
NCBI chr12:69,230,932...69,233,547
Ensembl chr12:69,230,931...69,233,544
G
Mir196b
microRNA 196b
multiple interactions
ISO
[Air Pollutants, Occupational results in increased abundance of Antimony] which results in increased expression of MIR196B mRNA
CTD
PMID:27506416
NCBI chr 6:52,207,061...52,207,145
Ensembl chr 6:52,207,061...52,207,145
G
Mt1
metallothionein 1
decreases expression
ISO
Antimony results in decreased expression of MT1X mRNA
CTD
PMID:17547211
NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
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Ndrg2
N-myc downstream regulated gene 2
decreases expression
ISO
Antimony results in decreased expression of NDRG2 mRNA
CTD
PMID:17547211
NCBI chr14:52,142,738...52,151,463
Ensembl chr14:52,142,728...52,151,615
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
decreases expression
ISO
Antimony results in decreased expression of NFKBIA mRNA
CTD
PMID:17547211
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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Nos2
nitric oxide synthase 2, inducible
multiple interactions
EXP ISO
[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of NOS2 protein 666-15 compound inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of NOS2 protein]; [Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of NOS2 mRNA; [Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of NOS2 protein; SB 203580 inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of NOS2 mRNA]; SB 203580 inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of NOS2 protein]
CTD
PMID:34571074
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
G
Nr0b2
nuclear receptor subfamily 0, group B, member 2
decreases expression
ISO
Antimony results in decreased expression of NR0B2 mRNA
CTD
PMID:17547211
NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
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Os9
amplified in osteosarcoma
decreases expression
ISO
Antimony results in decreased expression of OS9 mRNA
CTD
PMID:17547211
NCBI chr10:126,928,880...126,957,029
Ensembl chr10:126,931,519...126,957,000
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Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased expression of PCNA protein
CTD
PMID:34571074
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
G
Pdia4
protein disulfide isomerase associated 4
decreases expression
ISO
Antimony results in decreased expression of PDIA4 mRNA
CTD
PMID:17547211
NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364
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Pgc
progastricsin (pepsinogen C)
decreases expression
ISO
Antimony results in decreased expression of PGC mRNA
CTD
PMID:17547211
NCBI chr17:48,037,767...48,045,403
Ensembl chr17:48,037,767...48,045,407
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Pml
promyelocytic leukemia
multiple interactions
ISO
Antimony affects the localization of and results in increased sumoylation of PML protein
CTD
PMID:26049103
NCBI chr 9:58,125,359...58,157,077
Ensembl chr 9:58,125,359...58,157,069
G
Pparg
peroxisome proliferator activated receptor gamma
multiple interactions increases expression
EXP
Fulvestrant inhibits the reaction [Antimony results in increased expression of PPARG protein]
CTD
PMID:37858840
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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Ppih
peptidyl prolyl isomerase H
increases expression
ISO
Antimony results in increased expression of PPIH mRNA
CTD
PMID:17547211
NCBI chr 4:119,157,207...119,177,720
Ensembl chr 4:119,157,207...119,177,743
G
Psph
phosphoserine phosphatase
decreases expression
ISO
Antimony results in decreased expression of PSPH mRNA
CTD
PMID:17547211
NCBI chr 5:129,842,622...129,864,318
Ensembl chr 5:129,842,622...129,864,513
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression multiple interactions
EXP ISO
Antimony results in increased expression of PTGS2 protein Acetylcysteine inhibits the reaction [Antimony results in increased expression of PTGS2 protein]; MCOLN1 protein inhibits the reaction [Antimony results in increased expression of PTGS2 protein]
CTD
PMID:37858840 PMID:38097005
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
G
Pttg1
pituitary tumor-transforming gene 1
increases expression
ISO
Antimony results in increased expression of PTTG1 mRNA
CTD
PMID:17547211
NCBI chr11:43,311,097...43,317,417
Ensembl chr11:43,311,077...43,317,078
G
Rbpms
RNA binding protein gene with multiple splicing
increases expression
ISO
Antimony results in increased expression of RBPMS mRNA
CTD
PMID:17547211
NCBI chr 8:34,272,671...34,419,925
Ensembl chr 8:34,272,671...34,419,891
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
increases localization
EXP
Antimony results in increased localization of RELA protein
CTD
PMID:37858840
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
G
Rfc2
replication factor C (activator 1) 2
increases expression
ISO
Antimony results in increased expression of RFC2 mRNA
CTD
PMID:17547211
NCBI chr 5:134,611,544...134,627,182
Ensembl chr 5:134,610,220...134,630,659
G
Rnaseh2a
ribonuclease H2, large subunit
increases expression
ISO
Antimony results in increased expression of RNASEH2A mRNA
CTD
PMID:17547211
NCBI chr 8:85,683,239...85,694,498
Ensembl chr 8:85,683,239...85,696,396
G
Scd2
stearoyl-Coenzyme A desaturase 2
decreases expression
ISO
Antimony results in decreased expression of SCD mRNA
CTD
PMID:17547211
NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303
G
Sephs2
selenophosphate synthetase 2
decreases expression
ISO
Antimony results in decreased expression of SEPHS2 mRNA
CTD
PMID:17547211
NCBI chr 7:126,871,051...126,873,231
Ensembl chr 7:126,871,051...126,873,227
G
Serpinb1a
serine (or cysteine) peptidase inhibitor, clade B, member 1a
decreases expression
ISO
Antimony results in decreased expression of SERPINB1 mRNA
CTD
PMID:17547211
NCBI chr13:33,026,075...33,037,189
Ensembl chr13:33,026,075...33,035,168
G
Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
decreases expression
ISO
Antimony results in decreased expression of SERPINC1 mRNA
CTD
PMID:17547211
NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433
G
Sik1
salt inducible kinase 1
increases expression
ISO
Antimony results in increased expression of SIK1 mRNA
CTD
PMID:17547211
NCBI chr17:32,063,222...32,074,808
Ensembl chr17:32,063,224...32,074,778
G
Snrpa
small nuclear ribonucleoprotein polypeptide A
increases expression
ISO
Antimony results in increased expression of SNRPA mRNA
CTD
PMID:17547211
NCBI chr 7:26,886,431...26,895,696
Ensembl chr 7:26,886,430...26,895,696
G
Sod1
superoxide dismutase 1, soluble
multiple interactions decreases expression
ISO
Acetylcysteine inhibits the reaction [Antimony results in decreased expression of SOD1 protein]; ferrostatin-1 inhibits the reaction [Antimony results in decreased expression of SOD1 protein]; MCOLN1 protein inhibits the reaction [Antimony results in decreased expression of SOD1 protein]
CTD
PMID:38097005
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
G
Sqle
squalene epoxidase
decreases expression
ISO
Antimony results in decreased expression of SQLE mRNA
CTD
PMID:17547211
NCBI chr15:59,186,941...59,203,042
Ensembl chr15:59,186,926...59,203,041
G
Srebf1
sterol regulatory element binding transcription factor 1
increases expression
EXP
Antimony results in increased expression of SREBF1 mRNA
CTD
PMID:37858840
NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
G
Srsf1
serine and arginine-rich splicing factor 1
decreases expression
ISO
Antimony results in decreased expression of SRSF1 mRNA
CTD
PMID:17547211
NCBI chr11:87,937,325...87,944,583
Ensembl chr11:87,938,199...87,944,581
G
Srsf5
serine and arginine-rich splicing factor 5
decreases expression
ISO
Antimony results in decreased expression of SRSF5 mRNA
CTD
PMID:17547211
NCBI chr12:80,992,308...80,997,277
Ensembl chr12:80,992,278...80,997,281
G
St6galnac4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
decreases expression
ISO
Antimony results in decreased expression of ST6GALNAC4 mRNA
CTD
PMID:17547211
NCBI chr 2:32,477,100...32,489,710
Ensembl chr 2:32,477,107...32,489,710
G
Tardbp
TAR DNA binding protein
decreases expression
ISO
Antimony results in decreased expression of TARDBP mRNA
CTD
PMID:17547211
NCBI chr 4:148,696,839...148,711,672
Ensembl chr 4:148,696,839...148,711,476
G
Tnf
tumor necrosis factor
increases expression
EXP
Antimony results in increased expression of TNF mRNA
CTD
PMID:37858840
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
G
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
increases expression
ISO
Antimony results in increased expression of TNFAIP3 mRNA
CTD
PMID:17547211
NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
G
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
decreases expression
ISO
Antimony results in decreased expression of TNFSF10 mRNA
CTD
PMID:17547211
NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
G
Tob1
transducer of ErbB-2.1
decreases expression
ISO
Antimony results in decreased expression of TOB1 mRNA
CTD
PMID:17547211
NCBI chr11:94,100,668...94,106,321
Ensembl chr11:94,102,280...94,106,321
G
Tspan7
tetraspanin 7
decreases expression
ISO
Antimony results in decreased expression of TSPAN7 mRNA
CTD
PMID:17547211
NCBI chr X:10,351,355...10,462,843
Ensembl chr X:10,351,397...10,462,844
G
Tuft1
tuftelin 1
increases expression
ISO
Antimony results in increased expression of TUFT1 mRNA
CTD
PMID:17547211
NCBI chr 3:94,520,060...94,566,179
Ensembl chr 3:94,520,064...94,566,179
G
Txnrd1
thioredoxin reductase 1
increases expression
ISO
Antimony results in increased expression of TXNRD1 mRNA
CTD
PMID:17547211
NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
G
Tyms
thymidylate synthase
increases expression
ISO
Antimony results in increased expression of TYMS mRNA
CTD
PMID:17547211
NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615
G
Ube2c
ubiquitin-conjugating enzyme E2C
increases expression
ISO
Antimony results in increased expression of UBE2C mRNA
CTD
PMID:17547211
NCBI chr 2:164,611,849...164,614,822
Ensembl chr 2:164,611,818...164,620,742
G
Xbp1
X-box binding protein 1
increases expression
EXP
Antimony results in increased expression of XBP1 protein
CTD
PMID:37858840
NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
G
Zwint
ZW10 interactor
increases expression
ISO
Antimony results in increased expression of ZWINT mRNA
CTD
PMID:17547211
NCBI chr10:72,490,678...72,510,796
Ensembl chr10:72,490,677...72,510,796
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