Rnaseh2a (ribonuclease H2, large subunit) - Rat Genome Database
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Gene: Rnaseh2a (ribonuclease H2, large subunit) Mus musculus
Analyze
Symbol: Rnaseh2a
Name: ribonuclease H2, large subunit
RGD ID: 1316329
MGI Page MGI
Description: Predicted to have RNA-DNA hybrid ribonuclease activity. Involved in mismatch repair. Localizes to ribonuclease H2 complex. Is expressed in several structures, including embryo ectoderm; gut; hemolymphoid system gland; skin; and testis. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A); PARTICIPATES IN DNA replication pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2400006P09Rik; ribonuclease H2 subunit A; ribonuclease HI large subunit; ribonuclease HI subunit A; RNase H2 subunit A; RNase HI large subunit; RNASEHI; RNHIA; RNHL
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm15703  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,683,239 - 85,694,498 (-)NCBIGRCm39mm39
GRCm38884,956,610 - 84,969,598 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,956,610 - 84,969,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,480,509 - 87,489,910 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,847,772 - 87,856,190 (-)NCBImm8
MGSCv36884,658,774 - 84,667,268 (-)NCBImm8
Celera889,256,901 - 89,258,430 (-)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA)
ribonuclease H2 complex  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18799693  
PMID:19923215   PMID:21454563   PMID:21677750   PMID:21873635   PMID:22579044   PMID:23603115   PMID:23744109   PMID:26880576   PMID:30380406   PMID:32325033  


Genomics

Comparative Map Data
Rnaseh2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,683,239 - 85,694,498 (-)NCBIGRCm39mm39
GRCm38884,956,610 - 84,969,598 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,956,610 - 84,969,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,480,509 - 87,489,910 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,847,772 - 87,856,190 (-)NCBImm8
MGSCv36884,658,774 - 84,667,268 (-)NCBImm8
Celera889,256,901 - 89,258,430 (-)NCBICelera
Cytogenetic Map8C3NCBI
RNASEH2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,806,584 - 12,813,640 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1912,806,556 - 12,815,201 (+)EnsemblGRCh38hg38GRCh38
GRCh381912,806,584 - 12,813,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,912,863 - 12,924,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,778,428 - 12,785,462 (+)NCBINCBI36hg18NCBI36
Build 341912,778,427 - 12,785,462NCBI
Celera1912,807,135 - 12,814,169 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,489,074 - 12,496,108 (+)NCBIHuRef
CHM1_11912,917,906 - 12,924,940 (+)NCBICHM1_1
Rnaseh2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01926,074,980 - 26,084,780 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,074,987 - 26,084,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,050,603 - 37,060,340 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,841,614 - 24,851,834 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11924,846,439 - 24,856,658 (+)NCBI
Celera1922,743,902 - 22,753,535 (+)NCBICelera
Cytogenetic Map19q11NCBI
Rnaseh2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,884,533 - 31,898,433 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,884,533 - 31,894,159 (+)NCBIChiLan1.0ChiLan1.0
RNASEH2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,112,242 - 13,119,514 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,112,242 - 13,119,514 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,363,721 - 12,375,316 (+)NCBIMhudiblu_PPA_v0panPan3
RNASEH2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2049,345,266 - 49,355,167 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12049,345,258 - 49,352,944 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rnaseh2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366591,897,777 - 1,905,526 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNASEH2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,193,192 - 66,208,478 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,192,785 - 66,208,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,513,545 - 66,527,971 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNASEH2A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,493,752 - 11,501,167 (+)NCBI
ChlSab1.1 Ensembl611,493,764 - 11,501,363 (+)Ensembl
Rnaseh2a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901411,023 - 419,831 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2505
Count of miRNA genes:713
Interacting mature miRNAs:933
Transcripts:ENSMUST00000065049, ENSMUST00000109736, ENSMUST00000109738, ENSMUST00000122931, ENSMUST00000126029, ENSMUST00000128972, ENSMUST00000130902, ENSMUST00000137791, ENSMUST00000140561, ENSMUST00000147812
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000065049   ⟹   ENSMUSP00000066769
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,957,667 - 84,966,041 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109736   ⟹   ENSMUSP00000105358
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,956,610 - 84,969,740 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109738   ⟹   ENSMUSP00000105360
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,956,610 - 84,966,011 (-)Ensembl
RefSeq Acc Id: ENSMUST00000122931
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,957,974 - 84,965,961 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126029
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,957,678 - 84,958,116 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128972   ⟹   ENSMUSP00000121864
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,957,667 - 84,966,064 (-)Ensembl
RefSeq Acc Id: ENSMUST00000130902   ⟹   ENSMUSP00000116164
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,965,952 - 84,966,876 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137791
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,966,229 - 84,969,581 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140561   ⟹   ENSMUSP00000118442
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,965,607 - 84,969,767 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147812   ⟹   ENSMUSP00000120374
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,957,667 - 84,969,440 (-)Ensembl
RefSeq Acc Id: NM_001364370   ⟹   NP_001351299
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,684,296 - 85,692,705 (-)NCBI
GRCm38884,957,667 - 84,966,076 (-)NCBI
Sequence:
RefSeq Acc Id: NM_027187   ⟹   NP_081463
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,683,239 - 85,692,705 (-)NCBI
GRCm38884,956,610 - 84,966,076 (-)NCBI
MGSCv37887,480,509 - 87,489,910 (-)RGD
Celera889,256,901 - 89,258,430 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011248497   ⟹   XP_011246799
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,684,293 - 85,694,498 (-)NCBI
GRCm38884,957,666 - 84,969,598 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_081463   ⟸   NM_027187
- Peptide Label: isoform 1
- UniProtKB: Q9CWY8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011246799   ⟸   XM_011248497
- Peptide Label: isoform X1
- UniProtKB: Q9CWY8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001351299   ⟸   NM_001364370
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000116164   ⟸   ENSMUST00000130902
RefSeq Acc Id: ENSMUSP00000066769   ⟸   ENSMUST00000065049
RefSeq Acc Id: ENSMUSP00000120374   ⟸   ENSMUST00000147812
RefSeq Acc Id: ENSMUSP00000118442   ⟸   ENSMUST00000140561
RefSeq Acc Id: ENSMUSP00000105360   ⟸   ENSMUST00000109738
RefSeq Acc Id: ENSMUSP00000105358   ⟸   ENSMUST00000109736
RefSeq Acc Id: ENSMUSP00000121864   ⟸   ENSMUST00000128972
Protein Domains
RNase_HII

Promoters
RGD ID:8667719
Promoter ID:EPDNEW_M11891
Type:initiation region
Name:Rnaseh2a_1
Description:Mus musculus ribonuclease H2, large subunit , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,966,064 - 84,966,124EPDNEW
RGD ID:6843679
Promoter ID:MM_KWN:55118
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000109738,   OTTMUST00000048871,   OTTMUST00000048872,   OTTMUST00000048873
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36887,489,669 - 87,490,169 (-)MPROMDB
RGD ID:6843388
Promoter ID:MM_KWN:55120
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   Brain,   MEF_B4,   MEF_B6
Transcripts:LINCRNA_1018,   OTTMUST00000048868,   OTTMUST00000048869,   OTTMUST00000048874,   OTTMUST00000084731
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36887,493,209 - 87,493,709 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916974 AgrOrtholog
Ensembl Genes ENSMUSG00000052926 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000066769 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000105358 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000105360 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000116164 UniProtKB/TrEMBL
  ENSMUSP00000118442 UniProtKB/TrEMBL
  ENSMUSP00000120374 UniProtKB/Swiss-Prot
  ENSMUSP00000121864 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000065049 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000109736 UniProtKB/Swiss-Prot
  ENSMUST00000109738 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000128972 UniProtKB/TrEMBL
  ENSMUST00000130902 UniProtKB/TrEMBL
  ENSMUST00000140561 UniProtKB/TrEMBL
  ENSMUST00000147812 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.460 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RNase_H2_suA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_HII/HIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_HII/HIII_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_HII_hlx-loop-hlx_cap_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:69724 UniProtKB/Swiss-Prot
MGD MGI:1916974 ENTREZGENE
NCBI Gene 69724 ENTREZGENE
PANTHER PTHR10954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RNase_HII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnaseh2a PhenoGen
Superfamily-SCOP SSF53098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs TIGR00729 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.182470 ENTREZGENE
UniProt D3YWG3_MOUSE UniProtKB/TrEMBL
  D3Z6L4_MOUSE UniProtKB/TrEMBL
  F6RP29_MOUSE UniProtKB/TrEMBL
  Q05C51_MOUSE UniProtKB/TrEMBL
  Q9CWY8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8CHY8 UniProtKB/Swiss-Prot