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Gene:
Mapk1 ( Rattus norvegicus )
mitogen activated protein kinase 1
Description:kinase involved in intracellular signaling; component of Mapk signaling pathway
Synonyms:Erk2; extracellular-signal-regulated kinase 1;  
ArrayIDs:1398346_at; 5777862; 6094041; 1369078_at; 1373426_at; M64300_at; A_44_P386374; 6663748; 6295425; A_43_P12954; 6145785; 6332911; 6119902; A_44_P386375; 6198510; 6694484; 6066039; 5931521; GE21828; rc_AI103916_at; rc_AI172050_at; 6637753; 5958919;  (details...)
Gene Type:protein-coding
 
Additional Data
 
Homologs
Homo sapiens: MAPK1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Mapk1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusMapk1genome assembly 3.11186009328 - 86070984
  Rat Celera Assembly1182717574 - 82779220
  RGSC genome assembly v3.41185968732 - 86030389
  Cytogenetic11q23
Mus musculusMapk1Mouse genome assembly build 36.11616983475 - 17047546
  Cytogenetic1616 A3
Homo sapiensMAPK1human genome assembly2220447885 - 20546524
  Human genome assembly build 36.22220443946 - 20551970
  Cytogenetic22q11.21
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
 
 Annotation
Molecular Function
NoteReference
phosphorylates protein serine/threonine residues70317
Gene Ontology
protein kinase activity,  nucleotide binding,  kinase activity ...  (details...)
Biological Process
NoteReference
mediates long-term memory and long-term potentiation (LTP)631303
translocation to the nucleus is associated with the induction of late long-term potentiation (LTP); translocation activates transcription of immediate early genes (IEGs) after plasticity-inducing stimulation of neurons631303
functions in mitogenic signaling, activation is associated with cardiomyocyte hypertrophy70317
Gene Ontology
response to DNA damage stimulus,  B cell receptor signaling pathway,  response to lipopolysaccharide ...  (details...)
Cellular Component
NoteReference
enters the nucleus by diffusion without binding to a carrier625413
Gene Ontology
protein complex,  nucleus,  nucleolus ...  (details...)
Disease
NoteReference
active in breast cancer cells625413
G-alpha-q/11 mediates Mapk signaling in the ischemic hippocampus70672
Ontology
Brain Ischemia,  Myocardial Reperfusion Injury,  Myocardial Infarction ...  (details...)
Phenotype
Ontology
prenatal lethality,  absent ectoplacental cone,  absent extraembryonic ectoderm (details...)
Expression
NoteReference
expression in cardiac ventricle decreases 20-50 days after birth70317
protein specific activity decreases with age70317
expressed in all tissues70317
carbachol, a muscarinic antagonist, increases phosphorylation of Mapk3/Mapk1 in contra lateral hippocampus but not in ipsilateral hippocampus70672
Pathway
NoteReference
estrogen-mediated activation of the Erk/MAP kinase pathway immediately affects NMDA receptors and long term potentiation (LTP)70572
17 beta estradiol activates the extracellular regulated kinase/mitogen-activated protein kinase pathway at cellular level70572
Ontology
the extracellular signal-regulated Raf/Mek/Erk signaling pathway (details...)
Product
NoteReference
41 kDa protein625413
Regulation
NoteReference
activated by Endothelin-1 (ET-1)in glomerular mesangial cells727457
1-alpha,25-dihydroxyvitamin D3 (1a,25-(OH)2D3) increases the kinase activity via phospholipase C in growth zone (GC) cells of growth plate chondrocytes631303
activation requires platelet-derived growth factor (PDGF)-BB binding with platelet-derived growth factor receptor beta (Pdgrfb), but no activation is observed when there is ligand induced phosphorylation of the receptor631303
24R,25-dihydroxyvitamin D3 (24R,25-(OH)2D3) increases kinase activity via phospholipase D in resting zone (RC) cells631303
induced by glutamate, acetylcholine, and BDNF in neurons631303
ouabain induces activation in cardiac myocytes631303
activated protein undergoes nuclear translocation for phosphorylation70672
downregulation by ovariectomy70572
activated by estrogen and progestins625452
activated by Map2k1, Mek2 phosphorylation; nitric oxide enhances phosphorylation70310
 
 External Links
Databases
DATABASEIDSOURCE
SMART:S_TKcIPI
PROSITE:PROTEIN_KINASE_STIPI
PROSITE:PROTEIN_KINASE_DOMIPI
PROSITE:PROTEIN_KINASE_ATPIPI
PROSITE:MAPKIPI
UNIPARC:UPI0000DC19BBIPI
UNIPARC:UPI0000003FEAIPI
KEGG Report:rno:116590ENTREZGENE
HomoloGene Group ID:37670ENTREZGENE
Germonline:70500
Pfam:PkinaseIPI
KEGG Pathway:04150ENTREZGENE
KEGG Pathway:04270ENTREZGENE
KEGG Pathway:04370ENTREZGENE
KEGG Pathway:04930ENTREZGENE
KEGG Pathway:04620ENTREZGENE
KEGG Pathway:05216ENTREZGENE
KEGG Pathway:04350ENTREZGENE
KEGG Pathway:04660ENTREZGENE
KEGG Pathway:05211ENTREZGENE
KEGG Pathway:04810ENTREZGENE
KEGG Pathway:05215ENTREZGENE
KEGG Pathway:05020ENTREZGENE
KEGG Pathway:05200ENTREZGENE
KEGG Pathway:05212ENTREZGENE
KEGG Pathway:05223ENTREZGENE
KEGG Pathway:04722ENTREZGENE
KEGG Pathway:04650ENTREZGENE
KEGG Pathway:05218ENTREZGENE
KEGG Pathway:04916ENTREZGENE
KEGG Pathway:04010ENTREZGENE
KEGG Pathway:04720ENTREZGENE
KEGG Pathway:04730ENTREZGENE
KEGG Pathway:04910ENTREZGENE
KEGG Pathway:04912ENTREZGENE
KEGG Pathway:05214ENTREZGENE
KEGG Pathway:04540ENTREZGENE
KEGG Pathway:04510ENTREZGENE
KEGG Pathway:04666ENTREZGENE
KEGG Pathway:04664ENTREZGENE
KEGG Pathway:04012ENTREZGENE
KEGG Pathway:05213ENTREZGENE
KEGG Pathway:04320ENTREZGENE
KEGG Pathway:05210ENTREZGENE
KEGG Pathway:05220ENTREZGENE
KEGG Pathway:04062ENTREZGENE
KEGG Pathway:05219ENTREZGENE
KEGG Pathway:04662ENTREZGENE
KEGG Pathway:04360ENTREZGENE
KEGG Pathway:05010ENTREZGENE
KEGG Pathway:04520ENTREZGENE
KEGG Pathway:05221ENTREZGENE
InterPro:Ser/Thr_prot_kinase_dom.IPI
InterPro:Ser/Thr_prot_kinase_AS.IPI
InterPro:Se/Thr_prot_kinase-like_dom.IPI
InterPro:Protein_kinase_ATP_BS.IPI
InterPro:Prot_kinase_cat_dom.IPI
InterPro:MAP_kinase_CS.IPI
InterPro:Kinase-like_dom.IPI
InterPro:Erk_1_2_MAPK.IPI
IPI:IPI00780313IPI
IPI:IPI00199688IPI
Ensembl Protein:ENSRNOP00000027901IPI
Ensembl Protein:ENSRNOP00000002533IPI
Entrez Gene:Mapk1ENTREZGENE
UniProt:MK01_RATIPI
Ensembl Genes:ENSRNOG00000001849IPI
Superfamily-SCOP:Kinase_likeIPI
PRINTS:ERK1ERK2MAPK.IPI
Sequences
Nucleotide:CH473999Get FASTASearch GEO Profiles
Nucleotide:M64300Get FASTASearch GEO Profiles
Nucleotide:NM_053842Get FASTASearch GEO Profiles
(View all 3 Nucleotide Accessions)
Protein:P63086Get FASTA
Protein:AAA41124Get FASTA
Protein:EDL77868Get FASTA
Protein:NP_446294Get FASTA
(View all 4 Protein Accessions)
Clusters
UniGene:34914
 
 References
Curated References
44 references in RGD related to Mapk1
Other References
272 other references at PubMed related to Mapk1
 
 Database Information
RGD ID70500
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
09-APR-03: Mapk1 mitogen activated protein kinase 1 APPROVED Symbol and Name status set to approved 629479
10-JUN-02: Mapk1 mitogen activated protein kinase 1 PROVISIONAL Symbol and Name status set to provisional 70585

       

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