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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:3305
Term: Calcimycin
Definition: An aminobenzoic acid that has formula C29H37N3O6.
Chemical ID: MESH:D000001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Calcimycin results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Calcimycin results in increased activity of MAPK1 protein]; AG 1879 inhibits the reaction [Calcimycin results in increased activity of MAPK1 protein]; Calcimycin results in increased activity of and results in increased phosphorylation of MAPK1 protein; Egtazic Acid inhibits the reaction [Calcimycin results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Gadolinium inhibits the reaction [Calcimycin results in increased phosphorylation of MAPK1 protein]; W 7 inhibits the reaction [Calcimycin results in increased activity of and results in increased phosphorylation of MAPK1 protein]PMID:11914123
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDCalcimycin results in increased phosphorylation of MAPK1 proteinPMID:19782052
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased phosphorylation of MAPK1 protein; Calcimycin results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol analog inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; resveratrol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased phosphorylation of MAPK1 protein]PMID:18776917 PMID:19416633
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