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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:6925
Term: microcystin-LR
Definition: A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Chemical ID: MESH:C057862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDcyanoginosin LR results in decreased phosphorylation of MAPK1 proteinPMID:36206955
Mapk1decreases phosphorylationISOMapk1 (Mus musculus)6480464CTDcyanoginosin LR results in decreased phosphorylation of MAPK1 proteinPMID:36206955
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDcyanoginosin LR results in increased phosphorylation of MAPK1 proteinPMID:21983652 PMID:22960429 PMID:23970801 PMID:27393157
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDcyanoginosin LR results in increased phosphorylation of MAPK1 proteinPMID:20934494 PMID:33474710
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPK1 protein]; [IGBP1 protein results in increased susceptibility to cyanoginosin LR] which results in increased phosphorylation of MAPK1 protein; cyanoginosin LR promotes the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]PMID:21983652 PMID:23970801 PMID:29984889
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDcyanoginosin LR promotes the reaction [Kainic Acid results in increased phosphorylation of MAPK1 protein]PMID:34352349
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