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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500 Species: Rattus norvegicus RGD Object: Gene Symbol: Mapk1 Name: mitogen activated protein kinase 1

Acc ID: CHEBI:9086 Term: (-)-selegiline Definition: A selegiline that has formula C13H17N. CasRN: 14611-51-9 Chemical ID: MESH:D012642

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	PD 98059 inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK1 protein]	PMID:22019741
increases phosphorylation	EXP		6480464	CTD	Selegiline results in increased phosphorylation of MAPK1 protein	PMID:22019741
multiple interactions	ISO	RGD:732502	6480464	CTD	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK1 protein]	PMID:16099847
increases phosphorylation	ISO	RGD:732502	6480464	CTD	Selegiline results in increased phosphorylation of MAPK1 protein	PMID:16099847