RGD Reference Report - Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. - Rat Genome Database

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Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.

Authors: Kim, Hyemee  Banerjee, Nivedita  Ivanov, Ivan  Pfent, Catherine M  Prudhomme, Kalan R  Bisson, William H  Dashwood, Roderick H  Talcott, Stephen T  Mertens-Talcott, Susanne U 
Citation: Kim H, etal., Mol Nutr Food Res. 2016 Sep;60(9):1912-23. doi: 10.1002/mnfr.201501008. Epub 2016 May 23.
RGD ID: 13800882
Pubmed: PMID:27028006   (View Abstract at PubMed)
PMCID: PMC5026564   (View Article at PubMed Central)
DOI: DOI:10.1002/mnfr.201501008   (Journal Full-text)


SCOPE: Tannin-rich fruits have been evaluated as alternative prevention strategies for colorectal cancer based on their anti-inflammatory properties. This study compared tannin-rich preparations from mango (rich in gallotannins) and pomegranate (rich in ellagitannins) in the dextran sodium sulfate-induced colitis model.
METHODS AND RESULTS: In rats, mango and pomegranate beverages decreased intestinal inflammation and the levels of pro-inflammatory cytokines in mucosa and serum. The mango beverage suppressed the ratio of phosphorylated/total protein expression of the IGF-1R-AKT/mTOR axis and downregulated mRNA expression of Igf1, Insr, and pik3cv. Pomegranate decreased p70S6K and RPS6, as well as Rps6ka2, Map2k2, and Mapk1 mRNA. In silico modeling indicated a high binding of docked of gallic acid to the catalytic domain of IGF-1R, which may suppress the activity of the enzyme. Ellagic acid docked effectively into the catalytic domains of both IGF-1R and EGFR. In vitro assays with lipopolysaccharide-treated CCD-18Co cells using polyphenolic extracts from each beverage, as well as pure compounds, corroborated the predictions made in silico.
CONCLUSION: Mango polyphenols inhibited the IGF-1R- AKT/mTOR axis, and pomegranate polyphenols downregulate the mTOR downstream pathway through reductions in ERK1/2. These results suggest that extracts rich in gallo- and ellagitannins act on different molecular targets in the protection against ulcerative colitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Colitis treatmentISOMapk1 (Rattus norvegicus)13800882; 13800882 RGD 
Experimental Colitis treatmentIEP 13800882 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mapk1  (mitogen activated protein kinase 1)

Genes (Mus musculus)
Mapk1  (mitogen-activated protein kinase 1)

Genes (Homo sapiens)
MAPK1  (mitogen-activated protein kinase 1)


Additional Information