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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases activityEXP 6480464CTDOkadaic Acid results in increased activity of MAPK1 proteinPMID:7723735
Mapk1increases phosphorylationEXP 6480464CTDOkadaic Acid results in increased phosphorylation of MAPK1 proteinPMID:23335626 PMID:24395787
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDOkadaic Acid results in increased activity of MAPK1 proteinPMID:19716839
Mapk1increases activityISOMapk1 (Mus musculus)6480464CTDOkadaic Acid results in increased activity of MAPK1 proteinPMID:19716839
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDOkadaic Acid results in increased phosphorylation of MAPK1 proteinPMID:27050422
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDOkadaic Acid promotes the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of MAPK1 protein]PMID:23775084
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPK1 protein]PMID:27050422
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