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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases activityEXP 6480464CTDEndosulfan results in decreased activity of MAPK1 proteinPMID:11767051
Mapk1decreases expressionEXP 6480464CTDEndosulfan results in decreased expression of MAPK1 mRNA; Endosulfan results in decreased expression of MAPK1 protein modified formPMID:31464424 PMID:34089567
Mapk1increases expressionEXP 6480464CTDEndosulfan results in increased expression of MAPK1 proteinPMID:31464424
Mapk1increases phosphorylationEXP 6480464CTDEndosulfan results in increased phosphorylation of MAPK1 proteinPMID:15531431 PMID:17174995 PMID:27092634 PMID:35137321
Mapk1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]PMID:15531431
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDEndosulfan results in increased phosphorylation of MAPK1 proteinPMID:32044604
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDEndosulfan results in increased phosphorylation of MAPK1 proteinPMID:21278053 PMID:25199686
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; [Endosulfan co-treated with LIF protein] results in increased phosphorylation of MAPK1 protein; calphostin C inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; Endosulfan results in increased phosphorylation of and results in increased activity of MAPK1 protein; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]PMID:14975756 PMID:15888667 PMID:22146149 PMID:32044604
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; Endosulfan inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]PMID:21278053 PMID:25199686
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