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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:2781
Term: apocynin
Definition: An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Chemical ID: MESH:C056165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTDacetovanillone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]PMID:23774252 PMID:24080574
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDacetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]PMID:16632126 PMID:21391979 PMID:22288910 PMID:24967690 PMID:26514923
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDacetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:20354174 PMID:30797899
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