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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:195325
Term: alpha-melanocyte stimulating hormone
Definition: A thirteen amino acid peptide hormone consisting of N-acetyl-L-Ser, L-Tyr, L-Ser, L-Met, L-Glu, L-His, L-Phe, L-Arg, L-Trp, Gly, L-Lys, L-Pro and L-valinamide units joined in sequence by peptide linkages. It is an endogenous melanocortin receptor agonist that exhibits anti-inflammatory activity.
Chemical ID: MESH:D000521
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDalpha-MSH results in increased phosphorylation of MAPK1 proteinPMID:29486182
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]; Resveratrol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]PMID:29486182
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