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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTD4-nonylphenol results in increased phosphorylation of MAPK1 proteinPMID:17174995 PMID:19463694
Mapk1multiple interactionsEXP 6480464CTD4-nonylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]PMID:20870566
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTD4-nonylphenol results in increased phosphorylation of MAPK1 proteinPMID:28849599
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD4-nonylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased phosphorylation of MAPK1 protein]PMID:20950447 PMID:28849599
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