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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:6736
Term: melittin
Definition: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active component of bee venom.
Chemical ID: MESH:D008555
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationEXP 6480464CTDMelitten results in decreased phosphorylation of MAPK1 proteinPMID:17654254
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDMelitten results in decreased phosphorylation of MAPK1 proteinPMID:23110475
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDMelitten results in increased phosphorylation of MAPK1 proteinPMID:22613720
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDMelitten inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Melitten inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Melitten results in increased phosphorylation of and results in increased activity of MAPK1 proteinPMID:17579088 PMID:20082219 PMID:22926441
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDMelitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:17570326
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