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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases expressionEXP 6480464CTDMethoxychlor results in decreased expression of MAPK1 mRNAPMID:16443925
Mapk1multiple interactionsEXP 6480464CTD[Genistein co-treated with Methoxychlor] results in decreased expression of MAPK1 mRNA; Methoxychlor results in increased phosphorylation of and results in increased activity of MAPK1 proteinPMID:16443925 PMID:27413106
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDMethoxychlor results in increased phosphorylation of MAPK1 proteinPMID:15979571 PMID:24814263
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[Methoxychlor co-treated with LIF protein] results in increased phosphorylation of MAPK1 proteinPMID:14975756
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Methoxychlor results in increased phosphorylation of MAPK1 protein]PMID:24814263
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