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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:64159
Term: 2-methyl-6-(phenylethynyl)pyridine
Definition: A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Chemical ID: MESH:C121465
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTD6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Dextroamphetamine results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein]]PMID:12377393 PMID:16600209
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [Oxidopamine affects the phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein]]PMID:16600209 PMID:19850060 PMID:27543109 PMID:33571554
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